hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03052
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| IFIT1 | Interferon-induced protein with tetratricopeptide repeats 1 (IFIT-1) (Interferon-induced 56 kDa protein) (IFI-56K) (P56) | UniProt NCBI |
| IFIT2 | Interferon-induced protein with tetratricopeptide repeats 2 (IFIT-2) (ISG-54 K) (Interferon-induced 54 kDa protein) (IFI-54K) (P54) | UniProt NCBI |
| IFIT3 | Interferon-induced protein with tetratricopeptide repeats 3 (IFIT-3) (CIG49) (ISG-60) (Interferon-induced 60 kDa protein) (IFI-60K) (Interferon-induced protein with tetratricopeptide repeats 4) (IFIT-4) (Retinoic acid-induced gene G protein) (P60) (RIG-G) | UniProt NCBI |
| RAB9B | Ras-related protein Rab-9B (Rab-9-like protein) (Rab-9L) | UniProt NCBI |
| PHACTR4 | Phosphatase and actin regulator 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-909733 | 8.34369774361e-05 | 0.6 | IFIT1 IFIT3 IFIT2 | Interferon alpha/beta signaling |
| WP:WP4197 | 0.000632959696686 | 0.4 | IFIT1 IFIT3 | The human immune response to tuberculosis |
| REAC:R-HSA-913531 | 0.00230616063943 | 0.6 | IFIT1 IFIT3 IFIT2 | Interferon Signaling |
| TF:M04020_1 | 0.0044914523029 | 0.6 | IFIT1 PHACTR4 IFIT3 | Factor: IRF8; motif: NCGAAACCGAAACT; match class: 1 |
| TF:M04014 | 0.0129837343661 | 0.8 | IFIT1 IFIT3 PHACTR4 IFIT2 | Factor: IRF3; motif: NNRRAANGGAAACCGAAACYR |
| TF:M04014_0 | 0.0129837343661 | 0.8 | IFIT1 IFIT3 PHACTR4 IFIT2 | Factor: IRF3; motif: NNRRAANGGAAACCGAAACYR; match class: 0 |
| TF:M00772_1 | 0.0137266123698 | 0.6 | IFIT1 IFIT3 IFIT2 | Factor: IRF; motif: RRAANTGAAASYGNV; match class: 1 |
| TF:M00453_1 | 0.0230792842837 | 0.8 | IFIT1 IFIT3 PHACTR4 IFIT2 | Factor: IRF-7; motif: TNSGAAWNCGAAANTNNN; match class: 1 |
| TF:M09733_1 | 0.0288485817032 | 0.8 | IFIT1 IFIT3 PHACTR4 IFIT2 | Factor: STAT2; motif: NRGAAANNGAAACTNA; match class: 1 |
| TF:M08887_1 | 0.0358473364726 | 0.6 | IFIT1 IFIT3 IFIT2 | Factor: IRF; motif: NNGAAANTGAAANN; match class: 1 |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| IFIT2 | PHACTR4 | 0.991 | 0.909 | bioplex (IFIT2,PHACTR4) bioplex_WMM |
| IFIT2 | IFIT1 | 0.277 | 0.485 | bioplex (IFIT2) bioplex_WMM |
| PHACTR4 | IFIT3 | 0.276 | 0.487 | bioplex (PHACTR4) bioplex_WMM |
| IFIT2 | IFIT3 | 0.162 | 0.42 | bioplex (IFIT2) bioplex_WMM |
| PHACTR4 | IFIT1 | 0.113 | 0.383 | bioplex (PHACTR4) bioplex_WMM |
| PHACTR4 | RAB9B | 0.051 | 0.296 | bioplex (RAB9B) bioplex_WMM |
| IFIT1 | IFIT3 | 0.021 | 0.188 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03052 has an average edge precision of 0.453 which is ranked 2858 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| IFIT1 | HuMAP2_03052 |
| IFIT2 | HuMAP2_03037 HuMAP2_03052 |
| IFIT3 | HuMAP2_03052 |
| RAB9B | HuMAP2_03052 HuMAP2_07002 |
| PHACTR4 | HuMAP2_03037 HuMAP2_03052 |