hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03066
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| IMMT | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | UniProt NCBI |
| SAMM50 | Sorting and assembly machinery component 50 homolog (Transformation-related gene 3 protein) (TRG-3) | UniProt NCBI |
| CHCHD6 | MICOS complex subunit MIC25 (Coiled-coil-helix cristae morphology protein 1) (Coiled-coil-helix-coiled-coil-helix domain-containing protein 6) | UniProt NCBI |
| CHCHD3 | MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3) | UniProt NCBI |
| MTX3 | Metaxin-3 | UniProt NCBI |
| MTX2 | Metaxin-2 (Mitochondrial outer membrane import complex protein 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6249 | 1.53631870449e-14 | 0.833333333333 | IMMT CHCHD3 CHCHD6 SAMM50 MTX2 | MIB complex |
| REAC:R-HSA-8949613 | 2.29330899426e-11 | 0.833333333333 | IMMT CHCHD3 CHCHD6 SAMM50 MTX2 | Cristae formation |
| REAC:R-HSA-1592230 | 6.28394919001e-09 | 0.833333333333 | IMMT CHCHD3 CHCHD6 SAMM50 MTX2 | Mitochondrial biogenesis |
| CORUM:6255 | 4.50508252789e-08 | 0.5 | IMMT CHCHD3 CHCHD6 | MICOS complex |
| REAC:R-HSA-1852241 | 2.15632898754e-06 | 0.833333333333 | IMMT CHCHD3 CHCHD6 SAMM50 MTX2 | Organelle biogenesis and maintenance |
| GO:0042407 | 1.00004074113e-05 | 0.666666666667 | IMMT CHCHD3 SAMM50 CHCHD6 | cristae formation |
| CORUM:6132 | 2.51655344529e-05 | 0.333333333333 | IMMT CHCHD3 | MINOS complex |
| GO:0007007 | 4.07918542432e-05 | 0.666666666667 | IMMT CHCHD3 SAMM50 CHCHD6 | inner mitochondrial membrane organization |
| GO:0061617 | 6.35345863999e-05 | 0.5 | IMMT CHCHD3 CHCHD6 | MICOS complex |
| REAC:R-HSA-1268020 | 0.000202041038028 | 0.5 | MTX2 SAMM50 CHCHD3 | Mitochondrial protein import |
| GO:0007006 | 0.00201287714577 | 0.666666666667 | IMMT CHCHD3 SAMM50 CHCHD6 | mitochondrial membrane organization |
| REAC:R-HSA-9609507 | 0.00296089666153 | 0.5 | MTX2 SAMM50 CHCHD3 | Protein localization |
| GO:0031305 | 0.0108183376095 | 0.5 | IMMT CHCHD3 CHCHD6 | integral component of mitochondrial inner membrane |
| GO:0031966 | 0.0109160303478 | 0.833333333333 | IMMT CHCHD3 CHCHD6 SAMM50 MTX2 | mitochondrial membrane |
| GO:0031304 | 0.0118307664632 | 0.5 | IMMT CHCHD3 CHCHD6 | intrinsic component of mitochondrial inner membrane |
| GO:0044455 | 0.0148506630994 | 0.666666666667 | IMMT CHCHD3 SAMM50 CHCHD6 | mitochondrial membrane part |
| GO:0005740 | 0.0151221141199 | 0.833333333333 | IMMT CHCHD3 CHCHD6 SAMM50 MTX2 | mitochondrial envelope |
| GO:0098798 | 0.0434575095048 | 0.666666666667 | IMMT CHCHD3 SAMM50 CHCHD6 | mitochondrial protein complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MTX2 | IMMT | 1.0 | 0.949 | hein_WMM bioplex (MTX2) bioplex_WMM Guru boldt hein (MTX2) fraction boldt_WMM |
| MTX2 | SAMM50 | 1.0 | 0.949 | hein_WMM bioplex (MTX2) bioplex_WMM boldt youn_WMM hein (MTX2) boldt_WMM |
| MTX2 | CHCHD6 | 1.0 | 0.949 | hein_WMM bioplex (MTX2) bioplex_WMM boldt hein (MTX2) boldt_WMM |
| MTX2 | CHCHD3 | 0.997 | 0.93 | hein_WMM bioplex (MTX2) bioplex_WMM boldt hein (MTX2) boldt_WMM |
| MTX2 | MTX3 | 0.996 | 0.926 | hein_WMM bioplex (MTX2) bioplex_WMM hein (MTX2) |
| SAMM50 | CHCHD3 | 0.73 | 0.735 | hein_WMM bioplex_WMM boldt hein (SAMM50) boldt_WMM |
| IMMT | CHCHD3 | 0.064 | 0.349 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| IMMT | CHCHD6 | 0.04 | 0.269 | hein_WMM bioplex_WMM boldt boldt_WMM |
| SAMM50 | CHCHD6 | 0.031 | 0.238 | hein_WMM bioplex_WMM boldt boldt_WMM |
| IMMT | SAMM50 | 0.022 | 0.199 | hein_WMM bioplex_WMM boldt boldt_WMM |
| CHCHD6 | CHCHD3 | 0.021 | 0.192 | hein_WMM bioplex_WMM boldt boldt_WMM |
| MTX3 | SAMM50 | 0.01 | 0.103 | hein_WMM bioplex_WMM WMM_only |
| MTX3 | IMMT | 0.009 | 0.111 | hein_WMM bioplex_WMM WMM_only |
| MTX3 | CHCHD6 | 0.009 | 0.095 | hein_WMM bioplex_WMM WMM_only |
| MTX3 | CHCHD3 | 0.008 | 0.06 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03066 has an average edge precision of 0.47 which is ranked 2698 out of all 6965 complexes.
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