hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_03070
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GPC4 | Glypican-4 (K-glypican) [Cleaved into: Secreted glypican-4] | UniProt NCBI |
| GPC6 | Glypican-6 [Cleaved into: Secreted glypican-6] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3656253 | 0.000152509035076 | 1.0 | GPC4 GPC6 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS |
| REAC:R-HSA-3656237 | 0.000152509035076 | 1.0 | GPC4 GPC6 | Defective EXT2 causes exostoses 2 |
| REAC:R-HSA-3560783 | 0.000286582912066 | 1.0 | GPC4 GPC6 | Defective B4GALT7 causes EDS, progeroid type |
| REAC:R-HSA-3560801 | 0.000286582912066 | 1.0 | GPC4 GPC6 | Defective B3GAT3 causes JDSSDHD |
| REAC:R-HSA-4420332 | 0.000286582912066 | 1.0 | GPC4 GPC6 | Defective B3GALT6 causes EDSP2 and SEMDJL1 |
| REAC:R-HSA-2024096 | 0.000351943927099 | 1.0 | GPC4 GPC6 | HS-GAG degradation |
| REAC:R-HSA-1971475 | 0.000462554875615 | 1.0 | GPC4 GPC6 | A tetrasaccharide linker sequence is required for GAG synthesis |
| REAC:R-HSA-2022928 | 0.000680424925724 | 1.0 | GPC4 GPC6 | HS-GAG biosynthesis |
| REAC:R-HSA-3560782 | 0.00124185928562 | 1.0 | GPC4 GPC6 | Diseases associated with glycosaminoglycan metabolism |
| REAC:R-HSA-975634 | 0.00137425723915 | 1.0 | GPC4 GPC6 | Retinoid metabolism and transport |
| REAC:R-HSA-6806667 | 0.00158542359541 | 1.0 | GPC4 GPC6 | Metabolism of fat-soluble vitamins |
| REAC:R-HSA-1793185 | 0.00181167326283 | 1.0 | GPC4 GPC6 | Chondroitin sulfate/dermatan sulfate metabolism |
| REAC:R-HSA-1638091 | 0.00205300624141 | 1.0 | GPC4 GPC6 | Heparan sulfate/heparin (HS-GAG) metabolism |
| GO:0098696 | 0.00450823411379 | 1.0 | GPC4 GPC6 | regulation of neurotransmitter receptor localization to postsynaptic specialization membrane |
| REAC:R-HSA-2187338 | 0.00465068760809 | 1.0 | GPC4 GPC6 | Visual phototransduction |
| GO:1904929 | 0.00676235117068 | 1.0 | GPC4 GPC6 | coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway |
| REAC:R-HSA-1630316 | 0.0102315127378 | 1.0 | GPC4 GPC6 | Glycosaminoglycan metabolism |
| REAC:R-HSA-3781865 | 0.0125744537382 | 1.0 | GPC4 GPC6 | Diseases of glycosylation |
| GO:0071936 | 0.0126230555186 | 1.0 | GPC4 GPC6 | coreceptor activity involved in Wnt signaling pathway |
| GO:1902683 | 0.0126230555186 | 1.0 | GPC4 GPC6 | regulation of receptor localization to synapse |
| HP:0005622 | 0.0165301917506 | 1.0 | GPC4 GPC6 | Broad long bones |
| REAC:R-HSA-196854 | 0.024074640537 | 1.0 | GPC4 GPC6 | Metabolism of vitamins and cofactors |
| GO:0099645 | 0.0247952876258 | 1.0 | GPC4 GPC6 | neurotransmitter receptor localization to postsynaptic specialization membrane |
| GO:0099633 | 0.0247952876258 | 1.0 | GPC4 GPC6 | protein localization to postsynaptic specialization membrane |
| GO:0099560 | 0.0351642260875 | 1.0 | GPC4 GPC6 | synaptic membrane adhesion |
| GO:1902473 | 0.0410249304355 | 1.0 | GPC4 GPC6 | regulation of protein localization to synapse |
| HP:0005050 | 0.0497341708567 | 0.5 | GPC6 | Anterolateral radial head dislocation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GPC4 | GPC6 | 0.038 | 0.265 | bioplex (GPC4,GPC6) bioplex_WMM |
Images
Click to enlarge
Complex HuMAP2_03070 has an average edge precision of 0.265 which is ranked 5117 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GPC4 | HuMAP2_03070 HuMAP2_04691 HuMAP2_04797 |
| GPC6 | HuMAP2_03070 HuMAP2_04691 HuMAP2_04797 |