hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_03076
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NFKBIA | NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3) | UniProt NCBI |
| NFKBIB | NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9) | UniProt NCBI |
| NFKBID | NF-kappa-B inhibitor delta (I-kappa-B-delta) (IkB-delta) (IkappaBdelta) (IkappaBNS) (T-cell activation NFKB-like protein) (TA-NFKBH) | UniProt NCBI |
| NFKBIE | NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon) | UniProt NCBI |
| RELA | Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) | UniProt NCBI |
| NFKB2 | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | UniProt NCBI |
| RELB | Transcription factor RelB (I-Rel) | UniProt NCBI |
| NFKB1 | Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] | UniProt NCBI |
| REL | Proto-oncogene c-Rel | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5193 | 3.07025830535e-24 | 0.888888888889 | RELA REL NFKBIE NFKB2 RELB NFKBIA NFKBIB NFKB1 | TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2) |
| CORUM:5232 | 8.97046411682e-19 | 0.777777777778 | RELA REL NFKBIB NFKB2 RELB NFKBIA NFKB1 | TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) |
| CORUM:5230 | 2.11537596482e-16 | 0.666666666667 | RELA NFKBIE NFKB2 REL NFKBIA NFKB1 | CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex |
| CORUM:2084 | 8.53043734036e-16 | 0.555555555556 | RELB NFKB1 NFKB2 REL RELA | NFKB1-NFKB2-REL-RELA-RELB complex |
| WP:WP4562 | 6.91777580967e-14 | 0.555555555556 | NFKBIE NFKB1 NFKBIA REL RELA | Canonical NF-KB pathway |
| WP:WP4329 | 1.9637446257e-13 | 0.666666666667 | RELA REL NFKB2 RELB NFKBIA NFKB1 | miRNAs involvement in the immune response in sepsis |
| WP:WP2036 | 1.26724246331e-12 | 0.666666666667 | RELA NFKBIB NFKB2 RELB NFKBIA NFKB1 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| CORUM:2086 | 2.54036423996e-12 | 0.444444444444 | RELB NFKB1 NFKB2 RELA | NFKB1-NFKB2-RELA-RELB complex |
| REAC:R-HSA-1810476 | 2.53785052515e-11 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | RIP-mediated NFkB activation via ZBP1 |
| CORUM:5233 | 3.61037807908e-11 | 0.555555555556 | NFKBIB RELA NFKB2 REL NFKB1 | TNF-alpha/NF-kappa B signaling complex 5 |
| KEGG:05169 | 6.80141483322e-11 | 0.777777777778 | RELA NFKBIE NFKB2 RELB NFKBIA NFKBIB NFKB1 | Epstein-Barr virus infection |
| REAC:R-HSA-1606322 | 8.33814755212e-11 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | ZBP1(DAI) mediated induction of type I IFNs |
| REAC:R-HSA-1169091 | 9.9342683468e-11 | 0.666666666667 | RELA NFKBIB REL NFKBIA NFKBIE NFKB1 | Activation of NF-kappaB in B cells |
| REAC:R-HSA-933542 | 1.07881261363e-10 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | TRAF6 mediated NF-kB activation |
| WP:WP3858 | 1.208641644e-10 | 0.555555555556 | RELB NFKB1 NFKB2 REL RELA | Toll-like Receptor Signaling |
| WP:WP3617 | 1.75174481801e-10 | 0.555555555556 | RELB NFKB1 NFKB2 REL RELA | Photodynamic therapy-induced NF-kB survival signaling |
| WP:WP231 | 1.77436782738e-10 | 0.666666666667 | NFKBIB NFKB2 REL NFKBIA NFKBIE NFKB1 | TNF alpha Signaling Pathway |
| REAC:R-HSA-1168372 | 2.58738494576e-10 | 0.666666666667 | RELA NFKBIB REL NFKBIA NFKBIE NFKB1 | Downstream signaling events of B Cell Receptor (BCR) |
| REAC:R-HSA-5603029 | 4.28277855008e-10 | 0.444444444444 | RELA NFKB2 NFKBIA NFKB1 | IkBA variant leads to EDA-ID |
| REAC:R-HSA-445989 | 5.82751762167e-10 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| WP:WP2203 | 9.18922602235e-10 | 0.555555555556 | RELB NFKB1 NFKB2 NFKBIA RELA | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| REAC:R-HSA-983705 | 1.37728989381e-09 | 0.666666666667 | RELA NFKBIB REL NFKBIA NFKBIE NFKB1 | Signaling by the B Cell Receptor (BCR) |
| WP:WP195 | 2.87399555453e-09 | 0.555555555556 | NFKBIB RELA NFKBIA REL NFKB1 | IL-1 signaling pathway |
| WP:WP2018 | 3.17902620667e-09 | 0.555555555556 | RELB NFKB1 NFKB2 NFKBIA RELA | RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| CORUM:5466 | 6.30476064954e-09 | 0.333333333333 | RELA NFKBIB REL | IKB(beta)-RELA-cREL complex |
| CORUM:5464 | 6.30476064954e-09 | 0.333333333333 | RELA NFKBIA NFKB1 | IKBA-p50-p65 Nf(kappa)B complex |
| CORUM:5465 | 6.30476064954e-09 | 0.333333333333 | NFKBIE REL RELA | IKB(epsilon)-RELA-cREL complex |
| CORUM:5467 | 6.30476064954e-09 | 0.333333333333 | RELA NFKBIA REL | IKB(alpha)-RELA-cREL complex |
| CORUM:5492 | 6.30476064954e-09 | 0.333333333333 | RELA NFKBIA NFKB1 | IKBA-p50-p65 Nf(kappa)B complex |
| KEGG:04920 | 7.94929201661e-09 | 0.555555555556 | NFKBIE NFKB1 NFKBIA NFKBIB RELA | Adipocytokine signaling pathway |
| KEGG:04662 | 1.00622511304e-08 | 0.555555555556 | NFKBIE NFKB1 NFKBIA NFKBIB RELA | B cell receptor signaling pathway |
| KEGG:04658 | 1.35531891684e-08 | 0.555555555556 | NFKBIE NFKB1 NFKBIA NFKBIB RELA | Th1 and Th2 cell differentiation |
| WP:WP254 | 1.82863103014e-08 | 0.555555555556 | NFKBIE NFKB1 NFKBIA NFKBIB RELA | Apoptosis |
| WP:WP262 | 2.19318222215e-08 | 0.444444444444 | RELA NFKB2 NFKBIA NFKB1 | EBV LMP1 signaling |
| KEGG:04064 | 2.34184896571e-08 | 0.555555555556 | RELB NFKB1 NFKB2 NFKBIA RELA | NF-kappa B signaling pathway |
| KEGG:05235 | 2.49741086216e-08 | 0.555555555556 | NFKBIE NFKB1 NFKBIA NFKBIB RELA | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| REAC:R-HSA-1834949 | 2.85311226409e-08 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | Cytosolic sensors of pathogen-associated DNA |
| KEGG:04659 | 3.61307387965e-08 | 0.555555555556 | NFKBIE NFKB1 NFKBIA NFKBIB RELA | Th17 cell differentiation |
| KEGG:04625 | 4.06248272697e-08 | 0.555555555556 | RELB NFKB1 NFKB2 NFKBIA RELA | C-type lectin receptor signaling pathway |
| KEGG:04660 | 4.55544195293e-08 | 0.555555555556 | NFKBIE NFKB1 NFKBIA NFKBIB RELA | T cell receptor signaling pathway |
| REAC:R-HSA-168928 | 5.66790374605e-08 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| KEGG:04380 | 9.04735341547e-08 | 0.555555555556 | RELB NFKB1 NFKB2 NFKBIA RELA | Osteoclast differentiation |
| REAC:R-HSA-5260271 | 1.07889289355e-07 | 0.444444444444 | RELA NFKB2 NFKBIA NFKB1 | Diseases of Immune System |
| REAC:R-HSA-5602358 | 1.07889289355e-07 | 0.444444444444 | RELA NFKB2 NFKBIA NFKB1 | Diseases associated with the TLR signaling cascade |
| KEGG:04722 | 1.0977062733e-07 | 0.555555555556 | NFKBIE NFKB1 NFKBIA NFKBIB RELA | Neurotrophin signaling pathway |
| REAC:R-HSA-975871 | 1.10283402808e-07 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168176 | 1.10283402808e-07 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-168142 | 1.10283402808e-07 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-975138 | 1.2472416002e-07 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-975155 | 1.32489631362e-07 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168181 | 1.32489631362e-07 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-168188 | 1.67504097569e-07 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-166058 | 1.67504097569e-07 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168138 | 1.67504097569e-07 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-168164 | 1.77317401913e-07 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-168179 | 1.98320468808e-07 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-5607764 | 1.98320468808e-07 | 0.555555555556 | RELB NFKB1 NFKB2 NFKBIA RELA | CLEC7A (Dectin-1) signaling |
| REAC:R-HSA-181438 | 1.98320468808e-07 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-166166 | 2.09541545077e-07 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 2.09541545077e-07 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | TRIF(TICAM1)-mediated TLR4 signaling |
| WP:WP4217 | 2.108617227e-07 | 0.555555555556 | RELB NFKB1 NFKB2 REL RELA | Ebola Virus Pathway on Host |
| REAC:R-HSA-9020702 | 2.59604420117e-07 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | Interleukin-1 signaling |
| KEGG:05134 | 5.07647020106e-07 | 0.444444444444 | RELA NFKB2 NFKBIA NFKB1 | Legionellosis |
| WP:WP4479 | 5.10856792569e-07 | 0.333333333333 | RELA NFKBIA NFKB1 | Supression of HMGB1 mediated inflammation by THBD |
| CORUM:5194 | 5.28640281587e-07 | 0.333333333333 | RELA NFKB2 REL | TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2) |
| REAC:R-HSA-166016 | 7.01472264759e-07 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | Toll Like Receptor 4 (TLR4) Cascade |
| WP:WP4480 | 7.66053581701e-07 | 0.333333333333 | RELA NFKBIA NFKB1 | Role Altered Glycolysation of MUC1 in Tumour Microenvironment |
| WP:WP2637 | 7.70585326433e-07 | 0.444444444444 | RELA NFKBIA NFKBIB NFKB1 | Structural Pathway of Interleukin 1 (IL-1) |
| REAC:R-HSA-446652 | 9.77386993847e-07 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | Interleukin-1 family signaling |
| REAC:R-HSA-5621481 | 9.77386993847e-07 | 0.555555555556 | RELB NFKB1 NFKB2 NFKBIA RELA | C-type lectin receptors (CLRs) |
| REAC:R-HSA-448706 | 1.062486017e-06 | 0.333333333333 | RELA NFKB2 NFKB1 | Interleukin-1 processing |
| REAC:R-HSA-3134963 | 1.062486017e-06 | 0.333333333333 | RELA NFKB2 NFKB1 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production |
| WP:WP3865 | 1.14864607294e-06 | 0.444444444444 | RELA NFKBIA NFKBIB NFKB1 | Novel intracellular components of RIG-I-like receptor (RLR) pathway |
| KEGG:05140 | 1.22519009449e-06 | 0.444444444444 | RELA NFKBIA NFKBIB NFKB1 | Leishmaniasis |
| GO:0038061 | 1.27416502295e-06 | 0.666666666667 | RELA REL NFKB2 RELB NFKBIA NFKB1 | NIK/NF-kappaB signaling |
| KEGG:04623 | 1.31559056519e-06 | 0.444444444444 | RELA NFKBIA NFKBIB NFKB1 | Cytosolic DNA-sensing pathway |
| CORUM:5196 | 1.38327895355e-06 | 0.333333333333 | RELA NFKB2 REL | TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1) |
| REAC:R-HSA-168898 | 1.66345275606e-06 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | Toll-like Receptor Cascades |
| KEGG:05203 | 1.88063502179e-06 | 0.555555555556 | RELA NFKB2 NFKBIA REL NFKB1 | Viral carcinogenesis |
| KEGG:05131 | 1.96701358767e-06 | 0.444444444444 | RELA NFKBIA NFKBIB NFKB1 | Shigellosis |
| KEGG:04622 | 1.96701358767e-06 | 0.444444444444 | RELA NFKBIA NFKBIB NFKB1 | RIG-I-like receptor signaling pathway |
| KEGG:05166 | 2.37703134265e-06 | 0.555555555556 | RELB NFKB1 NFKB2 NFKBIA RELA | Human T-cell leukemia virus 1 infection |
| WP:WP4655 | 2.94677100515e-06 | 0.444444444444 | RELA NFKBIA NFKBIB NFKB1 | Cytosolic DNA-sensing pathway |
| WP:WP2037 | 4.156699395e-06 | 0.444444444444 | RELA NFKBIA NFKBIB NFKB1 | Prolactin Signaling Pathway |
| WP:WP69 | 4.88482859735e-06 | 0.444444444444 | RELA NFKBIA REL NFKB1 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| REAC:R-HSA-209560 | 5.00280964656e-06 | 0.333333333333 | RELA NFKBIA NFKB1 | NF-kB is activated and signals survival |
| REAC:R-HSA-4755510 | 5.00280964656e-06 | 0.333333333333 | RELA NFKBIA NFKB2 | SUMOylation of immune response proteins |
| GO:0033256 | 7.62876038594e-06 | 0.333333333333 | NFKB1 NFKBIA NFKB2 | I-kappaB/NF-kappaB complex |
| WP:WP75 | 8.3923449037e-06 | 0.444444444444 | RELA NFKBIA NFKBIB NFKB1 | Toll-like Receptor Signaling Pathway |
| WP:WP23 | 8.3923449037e-06 | 0.444444444444 | RELA NFKBIA REL NFKB1 | B Cell Receptor Signaling Pathway |
| KEGG:05145 | 9.36468425411e-06 | 0.444444444444 | RELA NFKBIA NFKBIB NFKB1 | Toxoplasmosis |
| REAC:R-HSA-193639 | 1.10264957252e-05 | 0.333333333333 | RELA NFKBIA NFKB1 | p75NTR signals via NF-kB |
| REAC:R-HSA-844456 | 1.10264957252e-05 | 0.333333333333 | RELA NFKB2 NFKB1 | The NLRP3 inflammasome |
| WP:WP4658 | 1.14357930033e-05 | 0.444444444444 | RELA NFKBIA NFKBIB NFKB1 | Small cell lung cancer |
| WP:WP4482 | 1.20852531449e-05 | 0.333333333333 | RELA NFKBIA NFKB1 | Vitamin D in inflammatory diseases |
| CORUM:5460 | 1.34129279418e-05 | 0.222222222222 | RELA NFKB1 | p50-p65 NF(kappa)B complex |
| WP:WP1449 | 2.73950278181e-05 | 0.444444444444 | RELA NFKB2 NFKBIA NFKB1 | Regulation of toll-like receptor signaling pathway |
| REAC:R-HSA-622312 | 2.93091559048e-05 | 0.333333333333 | RELA NFKB2 NFKB1 | Inflammasomes |
| WP:WP2112 | 2.97049293071e-05 | 0.333333333333 | RELA NFKBIB NFKB1 | IL17 signaling pathway |
| KEGG:05162 | 3.24609454367e-05 | 0.444444444444 | RELA NFKBIA NFKBIB NFKB1 | Measles |
| WP:WP4496 | 3.31224002659e-05 | 0.333333333333 | RELA NFKBIA NFKB1 | Signal transduction through IL1R |
| GO:0007249 | 3.32431831541e-05 | 0.666666666667 | RELA REL NFKB2 RELB NFKBIA NFKB1 | I-kappaB kinase/NF-kappaB signaling |
| WP:WP3929 | 3.34361513233e-05 | 0.444444444444 | RELA NFKBIA NFKBIB NFKB1 | Chemokine signaling pathway |
| KEGG:04062 | 3.45445068696e-05 | 0.444444444444 | RELA NFKBIA NFKBIB NFKB1 | Chemokine signaling pathway |
| WP:WP4481 | 3.67915356407e-05 | 0.333333333333 | RELA NFKBIA NFKB1 | Resistin as a regulator of inflammation |
| WP:WP3414 | 3.67915356407e-05 | 0.333333333333 | RELA NFKBIA NFKB1 | Initiation of transcription and translation elongation at the HIV-1 LTR |
| REAC:R-HSA-5621575 | 4.02039297847e-05 | 0.333333333333 | RELB NFKB1 RELA | CD209 (DC-SIGN) signaling |
| CORUM:5461 | 4.02261743042e-05 | 0.222222222222 | RELA NFKB1 | p50-p65 NF(kappa)B-SRC1 complex |
| CORUM:5475 | 4.02261743042e-05 | 0.222222222222 | RELA NFKBIA | MURR1-NF(kappa)Bp65-IKBA complex |
| KEGG:05164 | 5.807900392e-05 | 0.444444444444 | RELA NFKBIA NFKBIB NFKB1 | Influenza A |
| REAC:R-HSA-168256 | 5.91085572158e-05 | 0.888888888889 | RELA REL NFKBIE NFKB2 RELB NFKBIA NFKBIB NFKB1 | Immune System |
| KEGG:04621 | 7.54323546943e-05 | 0.444444444444 | RELA NFKBIA NFKBIB NFKB1 | NOD-like receptor signaling pathway |
| GO:0032479 | 8.41206646001e-05 | 0.555555555556 | RELB NFKB1 NFKB2 REL RELA | regulation of type I interferon production |
| GO:0032606 | 8.83926428691e-05 | 0.555555555556 | RELB NFKB1 NFKB2 REL RELA | type I interferon production |
| REAC:R-HSA-1280218 | 9.914735111e-05 | 0.666666666667 | RELA NFKBIB REL NFKBIA NFKBIE NFKB1 | Adaptive Immune System |
| WP:WP1533 | 0.000103654201195 | 0.333333333333 | RELA NFKB2 NFKB1 | Vitamin B12 Metabolism |
| WP:WP4008 | 0.000111394549047 | 0.333333333333 | RELA NFKBIA NFKB1 | NO/cGMP/PKG mediated Neuroprotection |
| CORUM:3045 | 0.000134003222308 | 0.222222222222 | RELA NFKB1 | hs4 enhancer complex (faster migrating complex) |
| CORUM:5228 | 0.000134003222308 | 0.222222222222 | RELA REL | REL-MAP3K8-RELA-TNIP2-PAPOLA complex |
| REAC:R-HSA-1280215 | 0.000143638517377 | 0.666666666667 | RELA NFKBIB NFKB2 RELB NFKBIA NFKB1 | Cytokine Signaling in Immune system |
| WP:WP395 | 0.000198940296053 | 0.333333333333 | RELA NFKBIA NFKB1 | IL-4 Signaling Pathway |
| CORUM:2105 | 0.000200941842998 | 0.222222222222 | RELA NFKBIA | IkappaB kinase complex (IKBKB, CHUK, IKBKAP, NFKBIA, RELA, MAP3K14) |
| WP:WP176 | 0.000210812882961 | 0.333333333333 | RELA NFKB2 NFKB1 | Folate Metabolism |
| KEGG:05120 | 0.000276134574071 | 0.333333333333 | RELA NFKBIA NFKB1 | Epithelial cell signaling in Helicobacter pylori infection |
| WP:WP382 | 0.000323884519488 | 0.444444444444 | RELB NFKB1 NFKB2 RELA | MAPK Signaling Pathway |
| WP:WP4341 | 0.000356282764137 | 0.333333333333 | RELB NFKB2 NFKB1 | Non-genomic actions of 1,25 dihydroxyvitamin D3 |
| WP:WP2374 | 0.000373691677602 | 0.333333333333 | RELA NFKBIA NFKB1 | Oncostatin M Signaling Pathway |
| WP:WP2324 | 0.000391654898324 | 0.333333333333 | RELA NFKBIA NFKB1 | AGE/RAGE pathway |
| WP:WP3303 | 0.000391654898324 | 0.333333333333 | RELA NFKBIA NFKB1 | RAC1/PAK1/p38/MMP2 Pathway |
| WP:WP3926 | 0.000407531507116 | 0.222222222222 | RELA NFKB2 | ApoE and miR-146 in inflammation and atherosclerosis |
| KEGG:04657 | 0.00041885134954 | 0.333333333333 | RELA NFKBIA NFKB1 | IL-17 signaling pathway |
| GO:0006954 | 0.00044099522812 | 0.666666666667 | RELA REL NFKB2 RELB NFKBIA NFKB1 | inflammatory response |
| WP:WP15 | 0.000448954899509 | 0.333333333333 | RELA NFKB2 NFKB1 | Selenium Micronutrient Network |
| KEGG:05220 | 0.000495409919157 | 0.333333333333 | RELA NFKBIA NFKB1 | Chronic myeloid leukemia |
| KEGG:04010 | 0.000513735736637 | 0.444444444444 | RELB NFKB1 NFKB2 RELA | MAPK signaling pathway |
| WP:WP2034 | 0.000579659270678 | 0.333333333333 | RELA REL NFKB1 | Leptin signaling pathway |
| REAC:R-HSA-5660668 | 0.000645991629451 | 0.222222222222 | RELA NFKB1 | CLEC7A/inflammasome pathway |
| REAC:R-HSA-168249 | 0.000671255959836 | 0.666666666667 | RELA NFKBIB NFKB2 RELB NFKBIA NFKB1 | Innate Immune System |
| REAC:R-HSA-168643 | 0.000701309789929 | 0.333333333333 | RELA NFKB2 NFKB1 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| KEGG:04620 | 0.000779282816557 | 0.333333333333 | RELA NFKBIA NFKB1 | Toll-like receptor signaling pathway |
| KEGG:05142 | 0.000835094366543 | 0.333333333333 | RELA NFKBIA NFKB1 | Chagas disease (American trypanosomiasis) |
| WP:WP2355 | 0.000849456213585 | 0.333333333333 | RELA NFKBIA NFKB1 | Corticotropin-releasing hormone signaling pathway |
| KEGG:05215 | 0.000893484637349 | 0.333333333333 | RELA NFKBIA NFKB1 | Prostate cancer |
| KEGG:05222 | 0.000954509678262 | 0.333333333333 | RELA NFKBIA NFKB1 | Small cell lung cancer |
| KEGG:04668 | 0.000986027714005 | 0.333333333333 | RELA NFKBIA NFKB1 | TNF signaling pathway |
| REAC:R-HSA-5607761 | 0.0010222833809 | 0.333333333333 | RELB NFKB2 RELA | Dectin-1 mediated noncanonical NF-kB signaling |
| REAC:R-HSA-449147 | 0.00103386216669 | 0.555555555556 | RELA NFKB2 NFKBIA NFKBIB NFKB1 | Signaling by Interleukins |
| WP:WP4337 | 0.00106600707161 | 0.222222222222 | RELA NFKB1 | ncRNAs involved in STAT3 signaling in hepatocellular carcinoma |
| WP:WP3849 | 0.00127880758353 | 0.222222222222 | NFKB1 NFKBIA | MAPK and NFkB Signalling Pathways Inhibited by Yersinia YopJ |
| KEGG:04931 | 0.00130110821186 | 0.333333333333 | RELA NFKBIA NFKB1 | Insulin resistance |
| WP:WP1434 | 0.00151084440274 | 0.222222222222 | RELA NFKB1 | Osteopontin Signaling |
| REAC:R-HSA-3214841 | 0.00170176128955 | 0.333333333333 | RELA NFKB2 NFKB1 | PKMTs methylate histone lysines |
| KEGG:05135 | 0.00172190181766 | 0.333333333333 | RELA NFKBIA NFKB1 | Yersinia infection |
| REAC:R-HSA-2871837 | 0.00208997882383 | 0.333333333333 | RELA NFKBIA NFKB1 | FCERI mediated NF-kB activation |
| KEGG:04926 | 0.00211656132668 | 0.333333333333 | RELA NFKBIA NFKB1 | Relaxin signaling pathway |
| CORUM:0000000 | 0.00227951320903 | 0.888888888889 | RELA REL NFKBIE NFKB2 RELB NFKBIA NFKBIB NFKB1 | CORUM root |
| GO:0000980 | 0.00231643936992 | 0.444444444444 | RELB NFKB1 REL RELA | RNA polymerase II distal enhancer sequence-specific DNA binding |
| WP:WP4559 | 0.00232219124631 | 0.222222222222 | NFKB1 NFKB2 | Interactions between immune cells and microRNAs in tumor microenvironment |
| REAC:R-HSA-193692 | 0.00232265605894 | 0.222222222222 | RELA NFKB1 | Regulated proteolysis of p75NTR |
| KEGG:04210 | 0.00239110431686 | 0.333333333333 | RELA NFKBIA NFKB1 | Apoptosis |
| REAC:R-HSA-193704 | 0.00303330403098 | 0.333333333333 | RELA NFKBIA NFKB1 | p75 NTR receptor-mediated signalling |
| KEGG:05160 | 0.00307531184624 | 0.333333333333 | RELA NFKBIA NFKB1 | Hepatitis C |
| REAC:R-HSA-202424 | 0.00336291829224 | 0.333333333333 | RELA NFKBIA NFKB1 | Downstream TCR signaling |
| WP:WP2380 | 0.00359829901051 | 0.333333333333 | RELA NFKBIA NFKB1 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| GO:0001158 | 0.00407883187879 | 0.444444444444 | RELB NFKB1 REL RELA | enhancer sequence-specific DNA binding |
| KEGG:05161 | 0.00453889033858 | 0.333333333333 | RELA NFKBIA NFKB1 | Hepatitis B |
| KEGG:05202 | 0.00471517617195 | 0.333333333333 | RELA REL NFKB1 | Transcriptional misregulation in cancer |
| WP:WP2583 | 0.00488522165191 | 0.222222222222 | NFKB1 NFKBIA | T-Cell Receptor and Co-stimulatory Signaling |
| WP:WP4223 | 0.00531077348598 | 0.333333333333 | RELA REL NFKB1 | Ras Signaling |
| KEGG:05200 | 0.0053385061568 | 0.444444444444 | RELA NFKB2 NFKBIA NFKB1 | Pathways in cancer |
| KEGG:01523 | 0.00535834385835 | 0.222222222222 | RELA NFKB1 | Antifolate resistance |
| KEGG:05167 | 0.00546514556824 | 0.333333333333 | RELA NFKBIA NFKB1 | Kaposi sarcoma-associated herpesvirus infection |
| REAC:R-HSA-202403 | 0.00584565424376 | 0.333333333333 | RELA NFKBIA NFKB1 | TCR signaling |
| KEGG:04024 | 0.00597133352715 | 0.333333333333 | RELA NFKBIA NFKB1 | cAMP signaling pathway |
| WP:WP3851 | 0.00626958317319 | 0.222222222222 | NFKB1 NFKBIA | TLR4 Signaling and Tolerance |
| GO:0035326 | 0.00669088447012 | 0.444444444444 | RELB NFKB1 REL RELA | enhancer binding |
| KEGG:05130 | 0.00673017470033 | 0.333333333333 | RELA NFKBIA NFKB1 | Pathogenic Escherichia coli infection |
| KEGG:04014 | 0.00754950320522 | 0.333333333333 | RELA REL NFKB1 | Ras signaling pathway |
| REAC:R-HSA-2454202 | 0.00823856739508 | 0.333333333333 | RELA NFKBIA NFKB1 | Fc epsilon receptor (FCERI) signaling |
| KEGG:05170 | 0.00951877888355 | 0.333333333333 | RELA NFKBIA NFKB1 | Human immunodeficiency virus 1 infection |
| REAC:R-HSA-73887 | 0.0095313189047 | 0.333333333333 | RELA NFKBIA NFKB1 | Death Receptor Signalling |
| KEGG:05163 | 0.00994896227973 | 0.333333333333 | RELA NFKBIA NFKB1 | Human cytomegalovirus infection |
| HP:0006783 | 0.0101181244364 | 0.222222222222 | NFKB1 NFKB2 | Posterior pharyngeal cleft |
| WP:WP3981 | 0.0101633326185 | 0.222222222222 | NFKB1 NFKBIA | miRNA regulation of prostate cancer signaling pathways |
| WP:WP3941 | 0.0128035909147 | 0.222222222222 | NFKBIE NFKB1 | Oxidative Damage |
| WP:WP1433 | 0.0135106647521 | 0.222222222222 | RELA NFKBIA | Nucleotide-binding Oligomerization Domain (NOD) pathway |
| WP:WP28 | 0.0135106647521 | 0.222222222222 | RELA NFKB1 | Selenium Metabolism and Selenoproteins |
| WP:WP3888 | 0.0147748088741 | 0.333333333333 | RELA NFKBIA NFKB1 | VEGFA-VEGFR2 Signaling Pathway |
| WP:WP2526 | 0.014981098359 | 0.222222222222 | NFKB1 NFKBIA | PDGF Pathway |
| TF:M04706 | 0.0152414084425 | 0.888888888889 | RELA NFKBID NFKBIE REL RELB NFKBIA NFKBIB NFKB1 | Factor: RelA; motif: GGGRAWTYC |
| TF:M04706_0 | 0.0152414084425 | 0.888888888889 | RELA NFKBID NFKBIE REL RELB NFKBIA NFKBIB NFKB1 | Factor: RelA; motif: GGGRAWTYC; match class: 0 |
| KEGG:05321 | 0.0155091288123 | 0.222222222222 | RELA NFKB1 | Inflammatory bowel disease (IBD) |
| WP:WP2586 | 0.0165264608152 | 0.222222222222 | RELA NFKB1 | Aryl Hydrocarbon Receptor |
| KEGG:05030 | 0.0169575949951 | 0.222222222222 | RELA NFKB1 | Cocaine addiction |
| HP:0100723 | 0.0175215982818 | 0.222222222222 | NFKB1 NFKB2 | Gastrointestinal stroma tumor |
| HP:0002088 | 0.0201605171723 | 0.555555555556 | RELB NFKB1 NFKB2 NFKBIA RELA | Abnormal lung morphology |
| REAC:R-HSA-3108232 | 0.0216576377654 | 0.333333333333 | RELA NFKBIA NFKB2 | SUMO E3 ligases SUMOylate target proteins |
| GO:0051090 | 0.0226128455423 | 0.555555555556 | NFKBIE NFKB1 NFKB2 NFKBIA RELA | regulation of DNA-binding transcription factor activity |
| WP:WP3863 | 0.0234543473359 | 0.222222222222 | NFKB1 NFKBIA | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| REAC:R-HSA-2990846 | 0.0240633864274 | 0.333333333333 | RELA NFKBIA NFKB2 | SUMOylation |
| KEGG:05133 | 0.0288729065193 | 0.222222222222 | RELA NFKB1 | Pertussis |
| KEGG:05221 | 0.0288729065193 | 0.222222222222 | RELA NFKB1 | Acute myeloid leukemia |
| HP:0002205 | 0.0290807270187 | 0.444444444444 | RELB NFKB2 NFKBIA NFKB1 | Recurrent respiratory infections |
| TF:M03563_1 | 0.0292565378811 | 0.666666666667 | REL NFKBIB NFKB2 RELB NFKBIA NFKB1 | Factor: RelA-p65; motif: GGGANTTTCCNN; match class: 1 |
| KEGG:04917 | 0.0308273619913 | 0.222222222222 | RELA NFKB1 | Prolactin signaling pathway |
| KEGG:05132 | 0.0359875712345 | 0.222222222222 | RELA NFKB1 | Salmonella infection |
| GO:0003682 | 0.0383617968432 | 0.555555555556 | RELB NFKB1 NFKB2 REL RELA | chromatin binding |
| KEGG:05212 | 0.0403966480843 | 0.222222222222 | RELA NFKB1 | Pancreatic cancer |
| HP:0011947 | 0.0422953859973 | 0.444444444444 | RELB NFKB2 NFKBIA NFKB1 | Respiratory tract infection |
| HP:0012252 | 0.0426881227377 | 0.555555555556 | RELB NFKB1 NFKB2 NFKBIA RELA | Abnormal respiratory system morphology |
| GO:0034097 | 0.0494502383582 | 0.666666666667 | RELA REL NFKB2 RELB NFKBIA NFKB1 | response to cytokine |
| CORUM:7316 | 0.0499262710315 | 0.111111111111 | NFKB1 | NFKB1-STAT3 complex |
| CORUM:3046 | 0.0499262710315 | 0.111111111111 | RELB | hs4 enhancer complex (slow migrating complex) |
| CORUM:7317 | 0.0499262710315 | 0.111111111111 | RELA | RELA-STAT3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NFKBIA | RELA | 1.0 | 0.949 | hein_WMM bioplex (NFKBIA) bioplex_WMM hein (NFKBIA) |
| NFKBIA | NFKB2 | 1.0 | 0.949 | hein_WMM bioplex (NFKBIA) bioplex_WMM hein (NFKBIA) |
| NFKBIA | REL | 1.0 | 0.949 | hein_WMM bioplex (NFKBIA,REL) bioplex_WMM hein (NFKBIA) |
| RELA | NFKBIB | 1.0 | 0.949 | bioplex (NFKBIB) bioplex_WMM |
| NFKBIA | NFKB1 | 1.0 | 0.949 | hein_WMM bioplex (NFKBIA) bioplex_WMM hein (NFKBIA) |
| REL | NFKBIB | 0.998 | 0.937 | bioplex (NFKBIB,REL) bioplex_WMM |
| RELB | NFKB2 | 0.997 | 0.933 | bioplex (RELB) bioplex_WMM |
| NFKB1 | NFKBIB | 0.957 | 0.863 | bioplex (NFKBIB) bioplex_WMM |
| NFKBIA | RELB | 0.902 | 0.826 | bioplex (NFKBIA,RELB) bioplex_WMM |
| NFKB2 | NFKBIB | 0.887 | 0.818 | bioplex (NFKBIB) bioplex_WMM |
| RELB | NFKB1 | 0.831 | 0.778 | bioplex (RELB) bioplex_WMM |
| NFKB2 | REL | 0.755 | 0.747 | hein_WMM bioplex (REL) bioplex_WMM |
| NFKB1 | REL | 0.656 | 0.695 | hein_WMM bioplex (REL) bioplex_WMM |
| NFKBIE | RELB | 0.528 | 0.633 | bioplex (RELB) bioplex_WMM |
| NFKBIE | REL | 0.415 | 0.571 | hein_WMM bioplex (REL) bioplex_WMM |
| RELA | REL | 0.375 | 0.547 | hein_WMM bioplex (REL) bioplex_WMM youn_WMM |
| RELB | REL | 0.241 | 0.468 | bioplex (REL,RELB) bioplex_WMM |
| RELB | RELA | 0.139 | 0.406 | bioplex (RELB) bioplex_WMM |
| NFKBIA | NFKBIB | 0.028 | 0.228 | bioplex (NFKBIA) bioplex_WMM |
| NFKB1 | NFKBID | 0.027 | 0.231 | bioplex (NFKBID) bioplex_WMM |
| RELA | NFKB1 | 0.017 | 0.173 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| RELA | NFKB2 | 0.017 | 0.171 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| NFKB1 | NFKB2 | 0.015 | 0.147 | hein_WMM bioplex_WMM WMM_only |
| NFKBIE | RELA | 0.01 | 0.12 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| NFKBIE | NFKB2 | 0.01 | 0.101 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| RELB | NFKBIB | 0.01 | 0.1 | bioplex_WMM WMM_only |
| NFKBIE | NFKB1 | 0.01 | 0.104 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| NFKBIE | NFKBIB | 0.008 | 0.028 | bioplex_WMM WMM_only |
| NFKB2 | NFKBID | 0.008 | 0.012 | bioplex (NFKBID) bioplex_WMM |
| REL | NFKBID | 0.006 | 0.006 | bioplex (NFKBID) bioplex_WMM |
| NFKBIA | NFKBIE | 0.003 | 0.008 | hein_WMM bioplex_WMM hein (NFKBIA) |
Images
Click to enlarge
Complex HuMAP2_03076 has an average edge precision of 0.497 which is ranked 2518 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NFKBIA | HuMAP2_01917 HuMAP2_02654 HuMAP2_03076 HuMAP2_03080 HuMAP2_06875 |
| NFKBIB | HuMAP2_01917 HuMAP2_03076 HuMAP2_06426 |
| NFKBID | HuMAP2_03076 |
| NFKBIE | HuMAP2_01917 HuMAP2_03076 |
| RELA | HuMAP2_01917 HuMAP2_03076 HuMAP2_06875 |
| NFKB2 | HuMAP2_01917 HuMAP2_03076 HuMAP2_03896 |
| RELB | HuMAP2_01917 HuMAP2_03076 HuMAP2_03080 |
| NFKB1 | HuMAP2_01917 HuMAP2_03076 |
| REL | HuMAP2_01917 HuMAP2_03076 HuMAP2_03896 |