hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03080
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NFKBIA | NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3) | UniProt NCBI |
| ANKRD27 | Ankyrin repeat domain-containing protein 27 (VPS9 domain-containing protein) | UniProt NCBI |
| RELB | Transcription factor RelB (I-Rel) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5193 | 0.00022139720913 | 0.666666666667 | NFKBIA RELB | TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2) |
| WP:WP4329 | 0.000416728443271 | 0.666666666667 | NFKBIA RELB | miRNAs involvement in the immune response in sepsis |
| CORUM:5232 | 0.000456110269427 | 0.666666666667 | NFKBIA RELB | TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) |
| WP:WP2036 | 0.000746902274868 | 0.666666666667 | NFKBIA RELB | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| WP:WP2203 | 0.000785169744646 | 0.666666666667 | NFKBIA RELB | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| WP:WP2018 | 0.00126905060241 | 0.666666666667 | NFKBIA RELB | RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| KEGG:04064 | 0.00137503215464 | 0.666666666667 | NFKBIA RELB | NF-kappa B signaling pathway |
| KEGG:04625 | 0.0017077231529 | 0.666666666667 | NFKBIA RELB | C-type lectin receptor signaling pathway |
| KEGG:04380 | 0.00234185543972 | 0.666666666667 | NFKBIA RELB | Osteoclast differentiation |
| KEGG:05169 | 0.00739741401711 | 0.666666666667 | NFKBIA RELB | Epstein-Barr virus infection |
| KEGG:05166 | 0.00857048201805 | 0.666666666667 | NFKBIA RELB | Human T-cell leukemia virus 1 infection |
| REAC:R-HSA-5607764 | 0.0279140119136 | 0.666666666667 | NFKBIA RELB | CLEC7A (Dectin-1) signaling |
| CORUM:3046 | 0.0499776345577 | 0.333333333333 | RELB | hs4 enhancer complex (slow migrating complex) |
| WP:WP3930 | 0.0499785733994 | 0.333333333333 | RELB | EDA Signalling in Hair Follicle Development |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NFKBIA | RELB | 0.902 | 0.826 | bioplex (NFKBIA,RELB) bioplex_WMM |
| ANKRD27 | NFKBIA | 0.723 | 0.732 | bioplex (NFKBIA) bioplex_WMM |
| ANKRD27 | RELB | 0.008 | 0.09 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03080 has an average edge precision of 0.549 which is ranked 2202 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NFKBIA | HuMAP2_01917 HuMAP2_02654 HuMAP2_03076 HuMAP2_03080 HuMAP2_06875 |
| ANKRD27 | HuMAP2_00073 HuMAP2_01677 HuMAP2_02654 HuMAP2_03080 |
| RELB | HuMAP2_01917 HuMAP2_03076 HuMAP2_03080 |