hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03086
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| APLF | Aprataxin and PNK-like factor (EC 4.2.99.18) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1) | UniProt NCBI |
| PARP1 | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) | UniProt NCBI |
| WRN | Werner syndrome ATP-dependent helicase (EC 3.6.4.12) (DNA helicase, RecQ-like type 3) (RecQ3) (Exonuclease WRN) (EC 3.1.-.-) (RecQ protein-like 2) | UniProt NCBI |
| PARP2 | Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-) | UniProt NCBI |
| XRCC6 | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | UniProt NCBI |
| XPC | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5235 | 9.01288868683e-09 | 0.5 | XRCC6 PARP1 WRN | WRN-Ku70-Ku80-PARP1 complex |
| REAC:R-HSA-73894 | 4.35751112638e-06 | 0.833333333333 | XRCC6 XPC PARP2 PARP1 WRN | DNA Repair |
| CORUM:4082 | 2.51655344529e-05 | 0.333333333333 | XRCC6 WRN | XRCC6-XRCC5-WRN complex |
| REAC:R-HSA-5693532 | 3.42582751834e-05 | 0.666666666667 | XRCC6 PARP2 PARP1 WRN | DNA Double-Strand Break Repair |
| GO:0006281 | 3.93579335792e-05 | 1.0 | APLF WRN PARP1 XPC XRCC6 PARP2 | DNA repair |
| REAC:R-HSA-5696394 | 4.99738490382e-05 | 0.5 | XPC PARP1 PARP2 | DNA Damage Recognition in GG-NER |
| REAC:R-HSA-5696395 | 7.30512953501e-05 | 0.5 | XPC PARP1 PARP2 | Formation of Incision Complex in GG-NER |
| CORUM:5179 | 8.38550741504e-05 | 0.333333333333 | XRCC6 PARP1 | NCOA6-DNA-PK-Ku-PARP1 complex |
| CORUM:1193 | 0.000176032589326 | 0.333333333333 | XRCC6 PARP1 | Rap1 complex |
| GO:0006302 | 0.000243760878037 | 0.833333333333 | XRCC6 PARP2 PARP1 APLF WRN | double-strand break repair |
| REAC:R-HSA-3108214 | 0.000336891436266 | 0.5 | XPC PARP1 WRN | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-5696399 | 0.000560531240275 | 0.5 | XPC PARP1 PARP2 | Global Genome Nucleotide Excision Repair (GG-NER) |
| GO:0006259 | 0.000579923761468 | 1.0 | APLF WRN PARP1 XPC XRCC6 PARP2 | DNA metabolic process |
| GO:0006974 | 0.000584852292019 | 1.0 | APLF WRN PARP1 XPC XRCC6 PARP2 | cellular response to DNA damage stimulus |
| REAC:R-HSA-110362 | 0.000620139265586 | 0.333333333333 | PARP1 PARP2 | POLB-Dependent Long Patch Base Excision Repair |
| WP:WP3645 | 0.000952765433858 | 0.333333333333 | PARP1 PARP2 | NAD+ biosynthetic pathways |
| REAC:R-HSA-5685939 | 0.000996295422965 | 0.333333333333 | PARP1 PARP2 | HDR through MMEJ (alt-NHEJ) |
| REAC:R-HSA-5696398 | 0.00126461482378 | 0.5 | XPC PARP1 PARP2 | Nucleotide Excision Repair |
| REAC:R-HSA-5693538 | 0.00239319227657 | 0.5 | PARP2 PARP1 WRN | Homology Directed Repair |
| KEGG:03410 | 0.00308902519676 | 0.333333333333 | PARP1 PARP2 | Base excision repair |
| GO:0071478 | 0.0038519413587 | 0.666666666667 | XRCC6 XPC PARP1 WRN | cellular response to radiation |
| REAC:R-HSA-3108232 | 0.00434965166143 | 0.5 | XPC PARP1 WRN | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 0.0048372157697 | 0.5 | XPC PARP1 WRN | SUMOylation |
| HP:0012056 | 0.00495018352279 | 0.333333333333 | WRN XPC | Cutaneous melanoma |
| REAC:R-HSA-110373 | 0.00662414399653 | 0.333333333333 | PARP1 PARP2 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| MIRNA:hsa-miR-196a-3p | 0.00877870101034 | 0.5 | XRCC6 PARP2 APLF | hsa-miR-196a-3p |
| REAC:R-HSA-73933 | 0.0131143608537 | 0.333333333333 | PARP1 PARP2 | Resolution of Abasic Sites (AP sites) |
| WP:WP4016 | 0.0165558163549 | 0.333333333333 | PARP1 WRN | DNA IR-damage and cellular response via ATR |
| REAC:R-HSA-5696400 | 0.0180541440856 | 0.333333333333 | PARP1 PARP2 | Dual Incision in GG-NER |
| GO:0140294 | 0.020283420769 | 0.333333333333 | PARP1 PARP2 | NAD DNA ADP-ribosyltransferase activity |
| GO:0018312 | 0.020283420769 | 0.333333333333 | PARP1 PARP2 | peptidyl-serine ADP-ribosylation |
| GO:0030592 | 0.020283420769 | 0.333333333333 | PARP1 PARP2 | DNA ADP-ribosylation |
| GO:0104004 | 0.0227135545744 | 0.666666666667 | XRCC6 XPC PARP1 WRN | cellular response to environmental stimulus |
| GO:0071214 | 0.0227135545744 | 0.666666666667 | XRCC6 XPC PARP1 WRN | cellular response to abiotic stimulus |
| GO:0032508 | 0.0398453744123 | 0.5 | XPC PARP1 WRN | DNA duplex unwinding |
| KEGG:04210 | 0.0474671394747 | 0.333333333333 | PARP1 PARP2 | Apoptosis |
| CORUM:7282 | 0.0499726005494 | 0.166666666667 | WRN | FEN1-WRN complex |
| CORUM:7352 | 0.0499726005494 | 0.166666666667 | PARP1 | PARP1-LIG3 complex |
| CORUM:1217 | 0.0499726005494 | 0.166666666667 | WRN | WRN-TRF2 complex |
| CORUM:4081 | 0.0499726005494 | 0.166666666667 | XRCC6 | Ku antigen complex |
| CORUM:328 | 0.0499726005494 | 0.166666666667 | XRCC6 | Ku antigen complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| XRCC6 | WRN | 0.999 | 0.949 | hein_WMM bioplex (XRCC6) bioplex_WMM boldt youn_WMM hein (XRCC6) boldt_WMM |
| APLF | XRCC6 | 0.872 | 0.804 | bioplex (APLF,XRCC6) bioplex_WMM |
| PARP2 | APLF | 0.543 | 0.644 | bioplex (APLF) bioplex_WMM |
| PARP2 | XPC | 0.383 | 0.551 | bioplex (XPC) bioplex_WMM |
| APLF | XPC | 0.345 | 0.535 | bioplex (APLF) bioplex_WMM |
| PARP1 | XRCC6 | 0.266 | 0.482 | bioplex (XRCC6) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| PARP1 | XPC | 0.112 | 0.381 | bioplex (XPC) bioplex_WMM gupta_WMM |
| PARP2 | XRCC6 | 0.088 | 0.352 | bioplex (XRCC6) bioplex_WMM boldt_WMM |
| APLF | PARP1 | 0.07 | 0.35 | bioplex (APLF) bioplex_WMM |
| XPC | XRCC6 | 0.038 | 0.263 | bioplex (XPC,XRCC6) bioplex_WMM gupta_WMM |
| PARP2 | PARP1 | 0.02 | 0.186 | bioplex_WMM WMM_only boldt_WMM |
| APLF | WRN | 0.008 | 0.085 | bioplex_WMM WMM_only |
| PARP2 | WRN | 0.008 | 0.044 | bioplex_WMM WMM_only boldt_WMM |
| XPC | WRN | 0.008 | 0.015 | bioplex_WMM WMM_only |
| PARP1 | WRN | 0.007 | 0.003 | bioplex_WMM boldt youn_WMM boldt_WMM |
Images
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Complex HuMAP2_03086 has an average edge precision of 0.376 which is ranked 3567 out of all 6965 complexes.
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