hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03090
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PSIP1 | PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) | UniProt NCBI |
| CDC123 | Cell division cycle protein 123 homolog (Protein D123) (HT-1080) (PZ32) | UniProt NCBI |
| METAP2 | Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M) | UniProt NCBI |
| EIF2S3 | Eukaryotic translation initiation factor 2 subunit 3 (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF-2-gamma X) (eIF-2gX) | UniProt NCBI |
| ABCF1 | ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50) (TNF-alpha-stimulated ABC protein) | UniProt NCBI |
| EIF2S1 | Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) | UniProt NCBI |
| EIF2S2 | Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF-2-beta) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5183 | 1.89175701516e-07 | 0.428571428571 | EIF2S3 EIF2S1 EIF2S2 | DNA-PK-Ku-eIF2-NF90-NF45 complex |
| REAC:R-HSA-72731 | 5.94732974666e-07 | 0.428571428571 | EIF2S3 EIF2S1 EIF2S2 | Recycling of eIF2:GDP |
| REAC:R-HSA-382556 | 1.05860673156e-05 | 0.571428571429 | EIF2S2 EIF2S3 EIF2S1 ABCF1 | ABC-family proteins mediated transport |
| GO:0005850 | 1.27120391093e-05 | 0.428571428571 | EIF2S3 EIF2S1 EIF2S2 | eukaryotic translation initiation factor 2 complex |
| REAC:R-HSA-381042 | 3.86423784685e-05 | 0.428571428571 | EIF2S3 EIF2S1 EIF2S2 | PERK regulates gene expression |
| WP:WP107 | 6.56529842161e-05 | 0.428571428571 | EIF2S3 EIF2S1 EIF2S2 | Translation Factors |
| REAC:R-HSA-72695 | 0.0002326333618 | 0.428571428571 | EIF2S3 EIF2S1 EIF2S2 | Formation of the ternary complex, and subsequently, the 43S complex |
| REAC:R-HSA-72649 | 0.000341719312652 | 0.428571428571 | EIF2S3 EIF2S1 EIF2S2 | Translation initiation complex formation |
| REAC:R-HSA-72702 | 0.000341719312652 | 0.428571428571 | EIF2S3 EIF2S1 EIF2S2 | Ribosomal scanning and start codon recognition |
| REAC:R-HSA-72662 | 0.000359631908423 | 0.428571428571 | EIF2S3 EIF2S1 EIF2S2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| GO:0008135 | 0.000820699113124 | 0.571428571429 | EIF2S2 EIF2S3 EIF2S1 ABCF1 | translation factor activity, RNA binding |
| REAC:R-HSA-381119 | 0.000961138164231 | 0.428571428571 | EIF2S3 EIF2S1 EIF2S2 | Unfolded Protein Response (UPR) |
| GO:0090079 | 0.00187525903549 | 0.571428571429 | EIF2S2 EIF2S3 EIF2S1 ABCF1 | translation regulator activity, nucleic acid binding |
| KEGG:03013 | 0.0018918646369 | 0.428571428571 | EIF2S3 EIF2S1 EIF2S2 | RNA transport |
| REAC:R-HSA-156827 | 0.00224533078464 | 0.428571428571 | EIF2S3 EIF2S1 EIF2S2 | L13a-mediated translational silencing of Ceruloplasmin expression |
| REAC:R-HSA-72706 | 0.00230723415657 | 0.428571428571 | EIF2S3 EIF2S1 EIF2S2 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| REAC:R-HSA-72613 | 0.00277242686137 | 0.428571428571 | EIF2S3 EIF2S1 EIF2S2 | Eukaryotic Translation Initiation |
| REAC:R-HSA-72737 | 0.00277242686137 | 0.428571428571 | EIF2S3 EIF2S1 EIF2S2 | Cap-dependent Translation Initiation |
| GO:0045182 | 0.00484567677782 | 0.571428571429 | EIF2S2 EIF2S3 EIF2S1 ABCF1 | translation regulator activity |
| REAC:R-HSA-382551 | 0.0140299310137 | 0.571428571429 | EIF2S2 EIF2S3 EIF2S1 ABCF1 | Transport of small molecules |
| GO:0006413 | 0.0266230678728 | 0.571428571429 | EIF2S2 CDC123 EIF2S1 EIF2S3 | translational initiation |
| GO:0003743 | 0.0336257766492 | 0.428571428571 | EIF2S3 EIF2S1 EIF2S2 | translation initiation factor activity |
| REAC:R-HSA-72766 | 0.0403505818332 | 0.428571428571 | EIF2S3 EIF2S1 EIF2S2 | Translation |
| GO:0006412 | 0.0466952219065 | 0.714285714286 | EIF2S2 CDC123 ABCF1 EIF2S1 EIF2S3 | translation |
| GO:0022618 | 0.0493528907409 | 0.571428571429 | PSIP1 EIF2S3 EIF2S1 EIF2S2 | ribonucleoprotein complex assembly |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EIF2S3 | EIF2S2 | 1.0 | 0.949 | hein_WMM bioplex (EIF2S2) bioplex_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM |
| EIF2S1 | EIF2S3 | 0.981 | 0.896 | hein_WMM bioplex_WMM Malo gupta_WMM fraction treiber_WMM |
| CDC123 | EIF2S2 | 0.884 | 0.816 | bioplex (EIF2S2) bioplex_WMM youn_WMM gupta_WMM |
| EIF2S1 | EIF2S2 | 0.511 | 0.63 | hein_WMM bioplex (EIF2S2) bioplex_WMM Malo gupta_WMM fraction treiber_WMM |
| EIF2S2 | PSIP1 | 0.291 | 0.493 | hein_WMM bioplex (EIF2S2) bioplex_WMM youn_WMM gupta_WMM fraction |
| ABCF1 | PSIP1 | 0.152 | 0.409 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| EIF2S2 | METAP2 | 0.047 | 0.29 | bioplex_WMM gupta_WMM fraction treiber_WMM |
| EIF2S2 | ABCF1 | 0.047 | 0.293 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| EIF2S1 | PSIP1 | 0.046 | 0.293 | hein_WMM bioplex_WMM gupta_WMM fraction |
| EIF2S3 | METAP2 | 0.034 | 0.264 | bioplex_WMM gupta_WMM fraction treiber_WMM |
| EIF2S3 | ABCF1 | 0.009 | 0.109 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| CDC123 | ABCF1 | 0.007 | 0.007 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| EIF2S1 | CDC123 | 0.007 | 0.009 | bioplex_WMM gupta_WMM WMM_only |
| CDC123 | PSIP1 | 0.007 | 0.01 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CDC123 | EIF2S3 | 0.007 | 0.005 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CDC123 | METAP2 | 0.007 | 0.0 | bioplex_WMM WMM_only |
| EIF2S3 | PSIP1 | 0.005 | 0.01 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| METAP2 | ABCF1 | 0.0 | 0.009 | bioplex_WMM gupta_WMM fraction treiber_WMM |
| EIF2S1 | ABCF1 | 0.0 | 0.013 | hein_WMM bioplex_WMM gupta_WMM fraction |
| METAP2 | PSIP1 | 0.0 | 0.009 | bioplex_WMM gupta_WMM fraction |
| EIF2S1 | METAP2 | 0.0 | 0.009 | bioplex_WMM gupta_WMM fraction treiber_WMM |
Images
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Complex HuMAP2_03090 has an average edge precision of 0.263 which is ranked 5168 out of all 6965 complexes.
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