hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03100
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CNPY3 | Protein canopy homolog 3 (CTG repeat protein 4a) (Expanded repeat-domain protein CAG/CTG 5) (Protein associated with TLR4) (Trinucleotide repeat-containing gene 5 protein) | UniProt NCBI |
| LUM | Lumican (Keratan sulfate proteoglycan lumican) (KSPG lumican) | UniProt NCBI |
| OGN | Mimecan (Osteoglycin) (Osteoinductive factor) (OIF) | UniProt NCBI |
| LRRTM2 | Leucine-rich repeat transmembrane neuronal protein 2 (Leucine-rich repeat neuronal 2 protein) | UniProt NCBI |
| ISLR | Immunoglobulin superfamily containing leucine-rich repeat protein | UniProt NCBI |
| LRRC40 | Leucine-rich repeat-containing protein 40 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3656244 | 0.000465187760645 | 0.333333333333 | LUM OGN | Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) |
| REAC:R-HSA-3656225 | 0.000465187760645 | 0.333333333333 | LUM OGN | Defective CHST6 causes MCDC1 |
| REAC:R-HSA-3656243 | 0.000465187760645 | 0.333333333333 | LUM OGN | Defective ST3GAL3 causes MCT12 and EIEE15 |
| REAC:R-HSA-2022857 | 0.00146070989197 | 0.333333333333 | LUM OGN | Keratan sulfate degradation |
| REAC:R-HSA-2022854 | 0.0055883638448 | 0.333333333333 | LUM OGN | Keratan sulfate biosynthesis |
| REAC:R-HSA-1638074 | 0.00895825109095 | 0.333333333333 | LUM OGN | Keratan sulfate/keratin metabolism |
| REAC:R-HSA-3560782 | 0.0163206320028 | 0.333333333333 | LUM OGN | Diseases associated with glycosaminoglycan metabolism |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LRRC40 | CNPY3 | 0.222 | 0.466 | bioplex (CNPY3,LRRC40) bioplex_WMM gupta_WMM |
| CNPY3 | LRRTM2 | 0.044 | 0.28 | bioplex (LRRTM2) bioplex_WMM |
| OGN | CNPY3 | 0.043 | 0.269 | bioplex (OGN) bioplex_WMM |
| CNPY3 | ISLR | 0.03 | 0.237 | bioplex (ISLR) bioplex_WMM |
| LUM | LRRC40 | 0.028 | 0.228 | bioplex (LUM) bioplex_WMM boldt boldt_WMM |
| LRRC40 | ISLR | 0.0 | 0.001 | bioplex (ISLR) bioplex_WMM |
Images
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Complex HuMAP2_03100 has an average edge precision of 0.247 which is ranked 5424 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CNPY3 | HuMAP2_03100 HuMAP2_05128 HuMAP2_06577 |
| LUM | HuMAP2_02015 HuMAP2_03100 HuMAP2_05128 HuMAP2_05221 |
| OGN | HuMAP2_00004 HuMAP2_03100 HuMAP2_06163 HuMAP2_06577 |
| LRRTM2 | HuMAP2_03100 HuMAP2_04610 HuMAP2_05587 HuMAP2_06577 |
| ISLR | HuMAP2_03100 |
| LRRC40 | HuMAP2_02015 HuMAP2_03100 HuMAP2_05128 HuMAP2_05221 HuMAP2_06577 |