hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03115
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GCLC | Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase) | UniProt NCBI |
| NPTN | Neuroplastin (Stromal cell-derived receptor 1) (SDR-1) | UniProt NCBI |
| GCLM | Glutamate--cysteine ligase regulatory subunit (GCS light chain) (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate--cysteine ligase modifier subunit) | UniProt NCBI |
| MARCO | Macrophage receptor MARCO (Macrophage receptor with collagenous structure) (Scavenger receptor class A member 2) | UniProt NCBI |
| TRPV5 | Transient receptor potential cation channel subfamily V member 5 (TrpV5) (Calcium transport protein 2) (CaT2) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Osm-9-like TRP channel 3) (OTRPC3) | UniProt NCBI |
| SLITRK4 | SLIT and NTRK-like protein 4 | UniProt NCBI |
| TNFAIP8L2 | Tumor necrosis factor alpha-induced protein 8-like protein 2 (TIPE2) (TNF alpha-induced protein 8-like protein 2) (TNFAIP8-like protein 2) (Inflammation factor protein 20) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7186 | 1.007158685e-05 | 0.285714285714 | GCLC GCLM | Glutamate-cysteine ligase |
| REAC:R-HSA-5578999 | 3.1663182739e-05 | 0.285714285714 | GCLC GCLM | Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) |
| WP:WP3 | 0.000914055366538 | 0.285714285714 | GCLC GCLM | Phytochemical activity on NRF2 transcriptional activation |
| WP:WP100 | 0.00153544244266 | 0.285714285714 | GCLC GCLM | Glutathione metabolism |
| REAC:R-HSA-174403 | 0.00208509668734 | 0.285714285714 | GCLC GCLM | Glutathione synthesis and recycling |
| WP:WP3612 | 0.00231614132512 | 0.285714285714 | GCLC GCLM | Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling |
| WP:WP4357 | 0.00231614132512 | 0.285714285714 | GCLC GCLM | NRF2-ARE regulation |
| WP:WP2525 | 0.00435375672817 | 0.285714285714 | GCLC GCLM | Trans-sulfuration and one carbon metabolism |
| KEGG:04216 | 0.00692040311449 | 0.285714285714 | GCLC GCLM | Ferroptosis |
| WP:WP4313 | 0.00702347294811 | 0.285714285714 | GCLC GCLM | Ferroptosis |
| GO:0004357 | 0.00946729163895 | 0.285714285714 | GCLC GCLM | glutamate-cysteine ligase activity |
| GO:0017109 | 0.00946729163895 | 0.285714285714 | GCLC GCLM | glutamate-cysteine ligase complex |
| KEGG:00270 | 0.0101703984163 | 0.285714285714 | GCLC GCLM | Cysteine and methionine metabolism |
| WP:WP3940 | 0.0112443046264 | 0.285714285714 | GCLC GCLM | One carbon metabolism and related pathways |
| KEGG:00480 | 0.0115481650768 | 0.285714285714 | GCLC GCLM | Glutathione metabolism |
| REAC:R-HSA-5579029 | 0.0118992043595 | 0.285714285714 | GCLC GCLM | Metabolic disorders of biological oxidation enzymes |
| REAC:R-HSA-156590 | 0.0176362111261 | 0.285714285714 | GCLC GCLM | Glutathione conjugation |
| MIRNA:hsa-miR-433-5p | 0.0240737136734 | 0.285714285714 | GCLC GCLM | hsa-miR-433-5p |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GCLC | GCLM | 0.716 | 0.73 | bioplex (GCLC) bioplex_WMM Guru fraction |
| GCLM | TRPV5 | 0.029 | 0.232 | bioplex (TRPV5) bioplex_WMM youn_WMM |
| GCLM | MARCO | 0.024 | 0.213 | fraction |
| NPTN | TNFAIP8L2 | 0.02 | 0.185 | bioplex (TNFAIP8L2) bioplex_WMM |
| GCLM | SLITRK4 | 0.02 | 0.185 | fraction |
| NPTN | GCLC | 0.02 | 0.184 | fraction |
Images
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Complex HuMAP2_03115 has an average edge precision of 0.288 which is ranked 4771 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GCLC | HuMAP2_00577 HuMAP2_01476 HuMAP2_02320 HuMAP2_03115 HuMAP2_03161 HuMAP2_05215 HuMAP2_05459 |
| NPTN | HuMAP2_00577 HuMAP2_02798 HuMAP2_03115 |
| GCLM | HuMAP2_03115 HuMAP2_03161 |
| MARCO | HuMAP2_03115 HuMAP2_03271 HuMAP2_05803 |
| TRPV5 | HuMAP2_03115 HuMAP2_03455 HuMAP2_05356 HuMAP2_06212 |
| SLITRK4 | HuMAP2_03115 |
| TNFAIP8L2 | HuMAP2_00577 HuMAP2_02798 HuMAP2_03115 |