hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03117
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDC73 | Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein) | UniProt NCBI |
| LEO1 | RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1167 | 1.67592346237e-05 | 1.0 | LEO1 CDC73 | Paf complex |
| REAC:R-HSA-8866654 | 0.00258092213206 | 1.0 | LEO1 CDC73 | E3 ubiquitin ligases ubiquitinate target proteins |
| WP:WP2853 | 0.00284130523568 | 1.0 | LEO1 CDC73 | Endoderm Differentiation |
| REAC:R-HSA-112382 | 0.00286750504412 | 1.0 | LEO1 CDC73 | Formation of RNA Pol II elongation complex |
| REAC:R-HSA-75955 | 0.00286750504412 | 1.0 | LEO1 CDC73 | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-8852135 | 0.00465068760809 | 1.0 | LEO1 CDC73 | Protein ubiquitination |
| REAC:R-HSA-674695 | 0.00556574181855 | 1.0 | LEO1 CDC73 | RNA Polymerase II Pre-transcription Events |
| REAC:R-HSA-201722 | 0.00656291627866 | 1.0 | LEO1 CDC73 | Formation of the beta-catenin:TCF transactivating complex |
| GO:0016593 | 0.0126230555186 | 1.0 | LEO1 CDC73 | Cdc73/Paf1 complex |
| GO:0001711 | 0.0162296428096 | 1.0 | LEO1 CDC73 | endodermal cell fate commitment |
| GO:0031442 | 0.020287053512 | 1.0 | LEO1 CDC73 | positive regulation of mRNA 3'-end processing |
| GO:0033523 | 0.029754345151 | 1.0 | LEO1 CDC73 | histone H2B ubiquitination |
| REAC:R-HSA-201681 | 0.0411120784555 | 1.0 | LEO1 CDC73 | TCF dependent signaling in response to WNT |
| HP:0006735 | 0.0497341708567 | 0.5 | CDC73 | Renal cortical adenoma |
| HP:0006781 | 0.0497341708567 | 0.5 | CDC73 | Hurthle cell thyroid adenoma |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LEO1 | CDC73 | 1.0 | 0.949 | hein_WMM bioplex (CDC73) bioplex_WMM Guru boldt youn_WMM hein (CDC73,LEO1) Malo fraction boldt_WMM |
Images
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Complex HuMAP2_03117 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CDC73 | HuMAP2_00070 HuMAP2_01728 HuMAP2_02419 HuMAP2_03117 |
| LEO1 | HuMAP2_00070 HuMAP2_01728 HuMAP2_02419 HuMAP2_03117 |