hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03120
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TBPL1 | TATA box-binding protein-like protein 1 (TBP-like protein 1) (21 kDa TBP-like protein) (Second TBP of unique DNA protein) (STUD) (TATA box-binding protein-related factor 2) (TBP-related factor 2) (TBP-like factor) (TBP-related protein) | UniProt NCBI |
| GTF2A1 | Transcription initiation factor IIA subunit 1 (General transcription factor IIA subunit 1) (TFIIAL) (Transcription initiation factor TFIIA 42 kDa subunit) (TFIIA-42) [Cleaved into: Transcription initiation factor IIA alpha chain (TFIIA p35 subunit); Transcription initiation factor IIA beta chain (TFIIA p19 subunit)] | UniProt NCBI |
| GTF2A2 | Transcription initiation factor IIA subunit 2 (General transcription factor IIA subunit 2) (TFIIA p12 subunit) (TFIIA-12) (TFIIAS) (Transcription initiation factor IIA gamma chain) (TFIIA-gamma) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03022 | 3.45230878393e-07 | 1.0 | GTF2A1 TBPL1 GTF2A2 | Basal transcription factors |
| CORUM:490 | 3.35600554376e-06 | 0.666666666667 | GTF2A1 GTF2A2 | TFIIA complex |
| CORUM:489 | 3.35600554376e-06 | 0.666666666667 | GTF2A1 GTF2A2 | TFIIA complex |
| CORUM:1221 | 1.00675659188e-05 | 0.666666666667 | GTF2A1 GTF2A2 | TFIIA-TRF2 complex |
| KEGG:05203 | 3.27739581519e-05 | 1.0 | GTF2A1 TBPL1 GTF2A2 | Viral carcinogenesis |
| CORUM:492 | 0.000352175507891 | 0.666666666667 | GTF2A1 GTF2A2 | DA complex |
| CORUM:493 | 0.000402468266231 | 0.666666666667 | GTF2A1 GTF2A2 | DAB complex |
| GO:0005672 | 0.00405722906526 | 0.666666666667 | GTF2A1 GTF2A2 | transcription factor TFIIA complex |
| REAC:R-HSA-73779 | 0.00722314394396 | 0.666666666667 | GTF2A1 GTF2A2 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| REAC:R-HSA-73776 | 0.00722314394396 | 0.666666666667 | GTF2A1 GTF2A2 | RNA Polymerase II Promoter Escape |
| REAC:R-HSA-167162 | 0.00722314394396 | 0.666666666667 | GTF2A1 GTF2A2 | RNA Polymerase II HIV Promoter Escape |
| REAC:R-HSA-167161 | 0.00722314394396 | 0.666666666667 | GTF2A1 GTF2A2 | HIV Transcription Initiation |
| REAC:R-HSA-75953 | 0.00722314394396 | 0.666666666667 | GTF2A1 GTF2A2 | RNA Polymerase II Transcription Initiation |
| REAC:R-HSA-76042 | 0.00722314394396 | 0.666666666667 | GTF2A1 GTF2A2 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
| REAC:R-HSA-167172 | 0.0165866686159 | 0.666666666667 | GTF2A1 GTF2A2 | Transcription of the HIV genome |
| REAC:R-HSA-6807505 | 0.0180259784934 | 0.666666666667 | GTF2A1 GTF2A2 | RNA polymerase II transcribes snRNA genes |
| REAC:R-HSA-674695 | 0.022155781492 | 0.666666666667 | GTF2A1 GTF2A2 | RNA Polymerase II Pre-transcription Events |
| CORUM:629 | 0.0499776345577 | 0.333333333333 | TBPL1 | BLM-TRF2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TBPL1 | GTF2A1 | 0.998 | 0.944 | bioplex (GTF2A1) bioplex_WMM youn_WMM gupta_WMM |
| GTF2A2 | GTF2A1 | 0.803 | 0.767 | bioplex (GTF2A1) bioplex_WMM youn_WMM gupta_WMM fraction |
| GTF2A2 | TBPL1 | 0.01 | 0.098 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_03120 has an average edge precision of 0.603 which is ranked 1928 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TBPL1 | HuMAP2_03120 HuMAP2_03257 HuMAP2_03977 |
| GTF2A1 | HuMAP2_03120 HuMAP2_03257 HuMAP2_03977 |
| GTF2A2 | HuMAP2_02668 HuMAP2_03120 HuMAP2_03257 HuMAP2_03977 |