hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03123
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ATP6V1E2 | V-type proton ATPase subunit E 2 (V-ATPase subunit E 2) (Vacuolar proton pump subunit E 2) | UniProt NCBI |
| ATP6V1B1 | V-type proton ATPase subunit B, kidney isoform (V-ATPase subunit B 1) (Endomembrane proton pump 58 kDa subunit) (Vacuolar proton pump subunit B 1) | UniProt NCBI |
| ATP6V1C2 | V-type proton ATPase subunit C 2 (V-ATPase subunit C 2) (Vacuolar proton pump subunit C 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04966 | 6.91664651832e-08 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | Collecting duct acid secretion |
| KEGG:05110 | 5.20131818177e-07 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | Vibrio cholerae infection |
| KEGG:05323 | 8.33606267338e-07 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | Rheumatoid arthritis |
| REAC:R-HSA-77387 | 9.09984147875e-07 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | Insulin receptor recycling |
| KEGG:05120 | 1.08230481824e-06 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | Epithelial cell signaling in Helicobacter pylori infection |
| KEGG:04721 | 1.44061718026e-06 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | Synaptic vesicle cycle |
| REAC:R-HSA-917977 | 1.64282711281e-06 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | Transferrin endocytosis and recycling |
| REAC:R-HSA-1222556 | 2.23000067859e-06 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | ROS and RNS production in phagocytes |
| KEGG:00190 | 8.02679835688e-06 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | Oxidative phosphorylation |
| REAC:R-HSA-917937 | 1.11518017806e-05 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | Iron uptake and transport |
| KEGG:04145 | 1.20588724809e-05 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | Phagosome |
| REAC:R-HSA-74752 | 1.46159459799e-05 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | Signaling by Insulin receptor |
| KEGG:04150 | 1.46555920905e-05 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | mTOR signaling pathway |
| KEGG:05165 | 0.000150762444884 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | Human papillomavirus infection |
| GO:0090383 | 0.000265644334868 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | phagosome acidification |
| REAC:R-HSA-983712 | 0.000301193962621 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | Ion channel transport |
| GO:0033572 | 0.000495506150782 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | transferrin transport |
| GO:0090382 | 0.000648444632805 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | phagosome maturation |
| GO:0051452 | 0.000968126020406 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | intracellular pH reduction |
| GO:0045851 | 0.00104259725275 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | pH reduction |
| GO:0006826 | 0.00238262534197 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | iron ion transport |
| GO:0051453 | 0.00435066388439 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | regulation of intracellular pH |
| GO:0030641 | 0.00475834847216 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | regulation of cellular pH |
| REAC:R-HSA-9006934 | 0.00501472976187 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | Signaling by Receptor Tyrosine Kinases |
| GO:0006885 | 0.00541641987402 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | regulation of pH |
| GO:0030004 | 0.00774864090629 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | cellular monovalent inorganic cation homeostasis |
| GO:0000041 | 0.00865355719779 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | transition metal ion transport |
| KEGG:01100 | 0.0105851300972 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | Metabolic pathways |
| GO:0008286 | 0.0121736852044 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | insulin receptor signaling pathway |
| REAC:R-HSA-382551 | 0.0162665061596 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | Transport of small molecules |
| GO:0055067 | 0.0170248502613 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | monovalent inorganic cation homeostasis |
| GO:0032869 | 0.0415322430011 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | cellular response to insulin stimulus |
| GO:0016241 | 0.0442598881134 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | regulation of macroautophagy |
| GO:0032868 | 0.0480789908723 | 1.0 | ATP6V1C2 ATP6V1E2 ATP6V1B1 | response to insulin |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ATP6V1C2 | ATP6V1E2 | 1.0 | 0.949 | bioplex (ATP6V1C2) bioplex_WMM |
| ATP6V1B1 | ATP6V1E2 | 1.0 | 0.949 | bioplex (ATP6V1B1) bioplex_WMM |
| ATP6V1C2 | ATP6V1B1 | 0.004 | 0.013 | bioplex (ATP6V1B1) bioplex_WMM |
Images
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Complex HuMAP2_03123 has an average edge precision of 0.637 which is ranked 1731 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ATP6V1E2 | HuMAP2_03123 HuMAP2_05404 HuMAP2_05625 HuMAP2_06811 HuMAP2_06925 |
| ATP6V1B1 | HuMAP2_00898 HuMAP2_03123 HuMAP2_05404 HuMAP2_05625 HuMAP2_06811 HuMAP2_06925 |
| ATP6V1C2 | HuMAP2_00898 HuMAP2_03123 HuMAP2_05404 HuMAP2_05625 HuMAP2_06925 |