hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03130
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SETD1A | Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.43) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) | UniProt NCBI |
| CXXC1 | CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) | UniProt NCBI |
| BOD1L1 | Biorientation of chromosomes in cell division protein 1-like 1 | UniProt NCBI |
| SETD1B | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.43) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | UniProt NCBI |
| BOD1 | Biorientation of chromosomes in cell division protein 1 (Biorientation defective protein 1) (Protein FAM44B) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6470 | 8.98111046407e-11 | 0.8 | SETD1B BOD1 CXXC1 BOD1L1 | Set1B complex |
| CORUM:2730 | 0.000100576175246 | 0.4 | CXXC1 SETD1B | Set1B complex |
| CORUM:2731 | 0.000100576175246 | 0.4 | SETD1A CXXC1 | Set1A complex |
| GO:0048188 | 0.000149729915117 | 0.6 | SETD1B SETD1A CXXC1 | Set1C/COMPASS complex |
| CORUM:6469 | 0.000301566439547 | 0.4 | SETD1A CXXC1 | Set1A complex |
| GO:0042800 | 0.000412725169389 | 0.6 | SETD1B SETD1A CXXC1 | histone methyltransferase activity (H3-K4 specific) |
| WP:WP2369 | 0.0071017099674 | 0.4 | SETD1A SETD1B | Histone Modifications |
| KEGG:00310 | 0.00779513141567 | 0.4 | SETD1A SETD1B | Lysine degradation |
| GO:0018024 | 0.00826983957236 | 0.6 | SETD1B SETD1A CXXC1 | histone-lysine N-methyltransferase activity |
| GO:0042054 | 0.0156368617465 | 0.6 | SETD1B SETD1A CXXC1 | histone methyltransferase activity |
| GO:0016279 | 0.0199719657189 | 0.6 | SETD1B SETD1A CXXC1 | protein-lysine N-methyltransferase activity |
| GO:0016278 | 0.0211681462149 | 0.6 | SETD1B SETD1A CXXC1 | lysine N-methyltransferase activity |
| REAC:R-HSA-3214841 | 0.0332320424718 | 0.4 | SETD1A SETD1B | PKMTs methylate histone lysines |
| MIRNA:hsa-miR-4758-3p | 0.0420272255805 | 0.4 | BOD1 SETD1A | hsa-miR-4758-3p |
| CORUM:0000000 | 0.0474603483533 | 1.0 | BOD1L1 BOD1 SETD1B SETD1A CXXC1 | CORUM root |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CXXC1 | SETD1B | 0.997 | 0.931 | hein_WMM bioplex (CXXC1) bioplex_WMM youn_WMM hein (CXXC1,SETD1B) |
| CXXC1 | SETD1A | 0.994 | 0.919 | hein_WMM bioplex (CXXC1) bioplex_WMM youn_WMM hein (CXXC1) fraction |
| CXXC1 | BOD1L1 | 0.98 | 0.896 | hein_WMM bioplex (CXXC1) bioplex_WMM youn_WMM hein (BOD1L1,CXXC1) |
| BOD1 | CXXC1 | 0.883 | 0.818 | hein_WMM bioplex (CXXC1) bioplex_WMM hein (BOD1,CXXC1) |
| SETD1A | BOD1L1 | 0.157 | 0.416 | hein_WMM bioplex_WMM youn_WMM hein (BOD1L1) |
| BOD1 | SETD1B | 0.039 | 0.263 | hein_WMM bioplex_WMM hein (BOD1) |
| SETD1B | SETD1A | 0.01 | 0.129 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| SETD1B | BOD1L1 | 0.01 | 0.105 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| BOD1 | BOD1L1 | 0.01 | 0.099 | hein_WMM bioplex_WMM WMM_only |
| BOD1 | SETD1A | 0.009 | 0.11 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03130 has an average edge precision of 0.469 which is ranked 2713 out of all 6965 complexes.
Related Complexes