hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_03131
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SLC25A3 | Phosphate carrier protein, mitochondrial (Phosphate transport protein) (PTP) (Solute carrier family 25 member 3) | UniProt NCBI |
| SLC25A6 | ADP/ATP translocase 3 (ADP,ATP carrier protein 3) (ADP,ATP carrier protein, isoform T2) (ANT 2) (Adenine nucleotide translocator 3) (ANT 3) (Solute carrier family 25 member 6) [Cleaved into: ADP/ATP translocase 3, N-terminally processed] | UniProt NCBI |
| UQCRC2 | Cytochrome b-c1 complex subunit 2, mitochondrial (Complex III subunit 2) (Core protein II) (Ubiquinol-cytochrome-c reductase complex core protein 2) | UniProt NCBI |
| TUFM | Elongation factor Tu, mitochondrial (EF-Tu) (P43) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0001942 | 0.000322204655363 | 0.75 | TUFM SLC25A3 UQCRC2 | Metabolic acidosis |
| HP:0002151 | 0.00160429803987 | 0.75 | TUFM SLC25A3 UQCRC2 | Increased serum lactate |
| WP:WP111 | 0.0071289861505 | 0.5 | SLC25A6 UQCRC2 | Electron Transport Chain (OXPHOS system in mitochondria) |
| HP:0001941 | 0.0114887691482 | 0.75 | TUFM SLC25A3 UQCRC2 | Acidosis |
| HP:0004360 | 0.014922003471 | 0.75 | TUFM SLC25A3 UQCRC2 | Abnormality of acid-base homeostasis |
| KEGG:05012 | 0.0156041830743 | 0.5 | SLC25A6 UQCRC2 | Parkinson disease |
| HP:0001987 | 0.023433582519 | 0.5 | TUFM UQCRC2 | Hyperammonemia |
| KEGG:05016 | 0.03037774612 | 0.5 | SLC25A6 UQCRC2 | Huntington disease |
| REAC:R-HSA-168277 | 0.0499190562503 | 0.25 | SLC25A6 | Influenza Virus Induced Apoptosis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SLC25A3 | UQCRC2 | 0.967 | 0.88 | bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| UQCRC2 | SLC25A6 | 0.855 | 0.793 | bioplex (SLC25A6) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| UQCRC2 | TUFM | 0.801 | 0.766 | bioplex (TUFM) bioplex_WMM Guru boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| SLC25A3 | SLC25A6 | 0.168 | 0.425 | bioplex (SLC25A6) bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| SLC25A3 | TUFM | 0.005 | 0.012 | bioplex (TUFM) bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| SLC25A6 | TUFM | 0.0 | 0.001 | bioplex (SLC25A6,TUFM) bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
Images
Click to enlarge
Complex HuMAP2_03131 has an average edge precision of 0.479 which is ranked 2641 out of all 6965 complexes.
Related Complexes