hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03132
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AKR1C1 | Aldo-keto reductase family 1 member C1 (EC 1.1.1.-) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC 1.1.1.149) (Chlordecone reductase homolog HAKRC) (Dihydrodiol dehydrogenase 1/2) (DD1/DD2) (High-affinity hepatic bile acid-binding protein) (HBAB) (Indanol dehydrogenase) (EC 1.1.1.112) (Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) | UniProt NCBI |
| PRDX5 | Peroxiredoxin-5, mitochondrial (EC 1.11.1.15) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) | UniProt NCBI |
| GSTO1 | Glutathione S-transferase omega-1 (GSTO-1) (EC 2.5.1.18) (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (S-(Phenacyl)glutathione reductase) (SPG-R) | UniProt NCBI |
| AKR1D1 | Aldo-keto reductase family 1 member D1 (EC 1.3.1.3) (3-oxo-5-beta-steroid 4-dehydrogenase) (Delta(4)-3-ketosteroid 5-beta-reductase) (Delta(4)-3-oxosteroid 5-beta-reductase) | UniProt NCBI |
| ENO3 | Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP702 | 0.000435304970934 | 0.6 | GSTO1 AKR1C1 AKR1D1 | Metapathway biotransformation Phase I and II |
| REAC:R-HSA-193775 | 0.00105126658749 | 0.4 | AKR1C1 AKR1D1 | Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| REAC:R-HSA-193807 | 0.00105126658749 | 0.4 | AKR1C1 AKR1D1 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol |
| REAC:R-HSA-193368 | 0.00282729215335 | 0.4 | AKR1C1 AKR1D1 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| KEGG:00140 | 0.00403884103568 | 0.4 | AKR1C1 AKR1D1 | Steroid hormone biosynthesis |
| REAC:R-HSA-192105 | 0.00584945327803 | 0.4 | AKR1C1 AKR1D1 | Synthesis of bile acids and bile salts |
| REAC:R-HSA-194068 | 0.00846479084427 | 0.4 | AKR1C1 AKR1D1 | Bile acid and bile salt metabolism |
| KEGG:00980 | 0.00858395707223 | 0.4 | GSTO1 AKR1C1 | Metabolism of xenobiotics by cytochrome P450 |
| GO:0047086 | 0.0450641792523 | 0.4 | AKR1C1 AKR1D1 | ketosteroid monooxygenase activity |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GSTO1 | ENO3 | 0.952 | 0.858 | Guru fraction |
| AKR1C1 | ENO3 | 0.774 | 0.752 | fraction |
| ENO3 | AKR1D1 | 0.759 | 0.749 | fraction |
| PRDX5 | ENO3 | 0.656 | 0.695 | Guru fraction |
| AKR1C1 | AKR1D1 | 0.029 | 0.231 | bioplex (AKR1C1) bioplex_WMM |
| GSTO1 | AKR1C1 | 0.007 | 0.002 | WMM_only treiber_WMM |
| PRDX5 | GSTO1 | 0.003 | 0.006 | bioplex (GSTO1,PRDX5) bioplex_WMM Guru gupta_WMM fraction treiber_WMM |
Images
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Complex HuMAP2_03132 has an average edge precision of 0.47 which is ranked 2696 out of all 6965 complexes.
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