hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03139
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| FXR2 | Fragile X mental retardation syndrome-related protein 2 | UniProt NCBI |
| FMR1 | Synaptic functional regulator FMR1 (Fragile X mental retardation protein 1) (FMRP) (Protein FMR-1) | UniProt NCBI |
| FXR1 | Fragile X mental retardation syndrome-related protein 1 (hFXR1p) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0044326 | 9.08185760231e-08 | 1.0 | FXR1 FMR1 FXR2 | dendritic spine neck |
| GO:1902737 | 3.63274304092e-07 | 1.0 | FXR1 FMR1 FXR2 | dendritic filopodium |
| KEGG:03013 | 1.76006400333e-05 | 1.0 | FXR1 FMR1 FXR2 | RNA transport |
| GO:0051489 | 0.0007056603357 | 1.0 | FXR1 FMR1 FXR2 | regulation of filopodium assembly |
| GO:0046847 | 0.00167324144465 | 1.0 | FXR1 FMR1 FXR2 | filopodium assembly |
| GO:0030175 | 0.00280229798177 | 1.0 | FXR1 FMR1 FXR2 | filopodium |
| GO:0000381 | 0.00295242108794 | 1.0 | FXR1 FMR1 FXR2 | regulation of alternative mRNA splicing, via spliceosome |
| GO:0033592 | 0.00405722906526 | 0.666666666667 | FXR1 FMR1 | RNA strand annealing activity |
| GO:0005844 | 0.00415585803882 | 1.0 | FXR1 FMR1 FXR2 | polysome |
| GO:0000380 | 0.00435066388439 | 1.0 | FXR1 FMR1 FXR2 | alternative mRNA splicing, via spliceosome |
| GO:0043197 | 0.0051907357126 | 1.0 | FXR1 FMR1 FXR2 | dendritic spine |
| GO:0044309 | 0.00541641987402 | 1.0 | FXR1 FMR1 FXR2 | neuron spine |
| GO:0003730 | 0.00588722337212 | 1.0 | FXR1 FMR1 FXR2 | mRNA 3'-UTR binding |
| GO:0030426 | 0.00588722337212 | 1.0 | FXR1 FMR1 FXR2 | growth cone |
| GO:0030427 | 0.00690911398953 | 1.0 | FXR1 FMR1 FXR2 | site of polarized growth |
| GO:0048024 | 0.00865355719779 | 1.0 | FXR1 FMR1 FXR2 | regulation of mRNA splicing, via spliceosome |
| GO:2001022 | 0.0103137207675 | 1.0 | FXR1 FMR1 FXR2 | positive regulation of response to DNA damage stimulus |
| GO:0045727 | 0.0110330947082 | 1.0 | FXR1 FMR1 FXR2 | positive regulation of translation |
| GO:0017148 | 0.0160613559883 | 1.0 | FXR1 FMR1 FXR2 | negative regulation of translation |
| GO:0098858 | 0.0190659069388 | 1.0 | FXR1 FMR1 FXR2 | actin-based cell projection |
| GO:0045182 | 0.0196004650773 | 1.0 | FXR1 FMR1 FXR2 | translation regulator activity |
| GO:0150034 | 0.0201449224406 | 1.0 | FXR1 FMR1 FXR2 | distal axon |
| GO:0034250 | 0.0218385980648 | 1.0 | FXR1 FMR1 FXR2 | positive regulation of cellular amide metabolic process |
| GO:0034249 | 0.022423560513 | 1.0 | FXR1 FMR1 FXR2 | negative regulation of cellular amide metabolic process |
| GO:0043484 | 0.0255054888903 | 1.0 | FXR1 FMR1 FXR2 | regulation of RNA splicing |
| GO:0050684 | 0.0261539335231 | 1.0 | FXR1 FMR1 FXR2 | regulation of mRNA processing |
| GO:0060491 | 0.0281650200706 | 1.0 | FXR1 FMR1 FXR2 | regulation of cell projection assembly |
| GO:0120032 | 0.0281650200706 | 1.0 | FXR1 FMR1 FXR2 | regulation of plasma membrane bounded cell projection assembly |
| GO:0014069 | 0.033252767518 | 1.0 | FXR1 FMR1 FXR2 | postsynaptic density |
| GO:0099572 | 0.0364177948924 | 1.0 | FXR1 FMR1 FXR2 | postsynaptic specialization |
| GO:0032279 | 0.0364177948924 | 1.0 | FXR1 FMR1 FXR2 | asymmetric synapse |
| GO:0098984 | 0.0372392489125 | 1.0 | FXR1 FMR1 FXR2 | neuron to neuron synapse |
| GO:0033267 | 0.0424286223465 | 1.0 | FXR1 FMR1 FXR2 | axon part |
| CORUM:5360 | 0.0499776345577 | 0.333333333333 | FXR1 | AGO2-FXR1-TNF(alpha)ARE-RNP complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| FMR1 | FXR1 | 0.976 | 0.888 | hein_WMM youn (FMR1,FXR1) bioplex (FMR1) bioplex_WMM youn_WMM gupta_WMM treiber_WMM |
| FMR1 | FXR2 | 0.778 | 0.752 | hein_WMM youn (FMR1,FXR2) bioplex (FMR1,FXR2) bioplex_WMM youn_WMM gupta_WMM treiber_WMM |
| FXR2 | FXR1 | 0.281 | 0.487 | hein_WMM youn (FXR1,FXR2) bioplex (FXR2) bioplex_WMM youn_WMM gupta_WMM treiber_WMM |
Images
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Complex HuMAP2_03139 has an average edge precision of 0.709 which is ranked 1345 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| FXR2 | HuMAP2_01230 HuMAP2_01454 HuMAP2_03096 HuMAP2_03139 HuMAP2_06246 |
| FMR1 | HuMAP2_00883 HuMAP2_01454 HuMAP2_03096 HuMAP2_03139 HuMAP2_04768 HuMAP2_06246 |
| FXR1 | HuMAP2_01454 HuMAP2_02628 HuMAP2_03096 HuMAP2_03139 HuMAP2_06246 |