hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03161
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GCLC | Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase) | UniProt NCBI |
| GCLM | Glutamate--cysteine ligase regulatory subunit (GCS light chain) (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate--cysteine ligase modifier subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5578999 | 1.67592346237e-06 | 1.0 | GCLM GCLC | Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) |
| CORUM:7186 | 1.67592346237e-06 | 1.0 | GCLM GCLC | Glutamate-cysteine ligase |
| WP:WP3 | 3.39049011863e-05 | 1.0 | GCLM GCLC | Phytochemical activity on NRF2 transcriptional activation |
| WP:WP100 | 5.70049437529e-05 | 1.0 | GCLM GCLC | Glutathione metabolism |
| WP:WP3612 | 8.60662876269e-05 | 1.0 | GCLM GCLC | Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling |
| WP:WP4357 | 8.60662876269e-05 | 1.0 | GCLM GCLC | NRF2-ARE regulation |
| KEGG:04216 | 0.000102565973527 | 1.0 | GCLM GCLC | Ferroptosis |
| REAC:R-HSA-174403 | 0.000110610948517 | 1.0 | GCLM GCLC | Glutathione synthesis and recycling |
| KEGG:00270 | 0.00015100395818 | 1.0 | GCLM GCLC | Cysteine and methionine metabolism |
| WP:WP2525 | 0.000162072879297 | 1.0 | GCLM GCLC | Trans-sulfuration and one carbon metabolism |
| KEGG:00480 | 0.000171575511903 | 1.0 | GCLM GCLC | Glutathione metabolism |
| WP:WP4313 | 0.000261924676198 | 1.0 | GCLM GCLC | Ferroptosis |
| WP:WP3940 | 0.000420271742178 | 1.0 | GCLM GCLC | One carbon metabolism and related pathways |
| GO:0017109 | 0.000450823411379 | 1.0 | GCLM GCLC | glutamate-cysteine ligase complex |
| GO:0004357 | 0.000450823411379 | 1.0 | GCLM GCLC | glutamate-cysteine ligase activity |
| REAC:R-HSA-5579029 | 0.000633499068778 | 1.0 | GCLM GCLC | Metabolic disorders of biological oxidation enzymes |
| REAC:R-HSA-156590 | 0.000940193062392 | 1.0 | GCLM GCLC | Glutathione conjugation |
| MIRNA:hsa-miR-433-5p | 0.00118137460211 | 1.0 | GCLM GCLC | hsa-miR-433-5p |
| WP:WP2884 | 0.00227460903014 | 1.0 | GCLM GCLC | NRF2 pathway |
| REAC:R-HSA-5668914 | 0.00641543501397 | 1.0 | GCLM GCLC | Diseases of metabolism |
| REAC:R-HSA-156580 | 0.0074829982595 | 1.0 | GCLM GCLC | Phase II - Conjugation of compounds |
| WP:WP2882 | 0.0123521888904 | 1.0 | GCLM GCLC | Nuclear Receptors Meta-Pathway |
| REAC:R-HSA-211859 | 0.0291459849342 | 1.0 | GCLM GCLC | Biological oxidations |
| GO:0006750 | 0.029754345151 | 1.0 | GCLM GCLC | glutathione biosynthetic process |
| WP:WP4518 | 0.0332875339197 | 0.5 | GCLC | Gamma-Glutamyl Cycle for the biosynthesis and degradation of glutathione, including diseases |
| GO:0019184 | 0.0351642260875 | 1.0 | GCLM GCLC | nonribosomal peptide biosynthetic process |
| GO:0016881 | 0.0473364581948 | 1.0 | GCLM GCLC | acid-amino acid ligase activity |
| HP:0006904 | 0.0497341708567 | 0.5 | GCLC | Late-onset spinocerebellar degeneration |
| WP:WP2333 | 0.0499262710315 | 0.5 | GCLM | Trans-sulfuration pathway |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GCLC | GCLM | 0.716 | 0.73 | bioplex (GCLC) bioplex_WMM Guru fraction |
Images
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Complex HuMAP2_03161 has an average edge precision of 0.73 which is ranked 1257 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GCLC | HuMAP2_00577 HuMAP2_01476 HuMAP2_02320 HuMAP2_03115 HuMAP2_03161 HuMAP2_05215 HuMAP2_05459 |
| GCLM | HuMAP2_03115 HuMAP2_03161 |