hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03163
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RHOA | Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12) | UniProt NCBI |
| RHOC | Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9) | UniProt NCBI |
| ARHGEF11 | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | UniProt NCBI |
| DAAM2 | Disheveled-associated activator of morphogenesis 2 | UniProt NCBI |
| ARHGEF1 | Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-416482 | 3.96024318077e-07 | 0.8 | RHOA RHOC ARHGEF11 ARHGEF1 | G alpha (12/13) signalling events |
| REAC:R-HSA-416572 | 2.63058148282e-06 | 0.6 | RHOC ARHGEF11 RHOA | Sema4D induced cell migration and growth-cone collapse |
| REAC:R-HSA-194840 | 4.24975536457e-06 | 0.8 | RHOA RHOC ARHGEF11 ARHGEF1 | Rho GTPase cycle |
| REAC:R-HSA-400685 | 4.80586315819e-06 | 0.6 | RHOC ARHGEF11 RHOA | Sema4D in semaphorin signaling |
| REAC:R-HSA-373755 | 8.78979375366e-05 | 0.6 | RHOC ARHGEF11 RHOA | Semaphorin interactions |
| KEGG:04928 | 0.000126322071771 | 0.6 | RHOA ARHGEF11 ARHGEF1 | Parathyroid hormone synthesis, secretion and action |
| KEGG:04270 | 0.000134356221711 | 0.6 | RHOA ARHGEF11 ARHGEF1 | Vascular smooth muscle contraction |
| REAC:R-HSA-193704 | 0.000275953181812 | 0.6 | RHOA ARHGEF11 ARHGEF1 | p75 NTR receptor-mediated signalling |
| REAC:R-HSA-5666185 | 0.000485460775426 | 0.4 | RHOC RHOA | RHO GTPases Activate Rhotekin and Rhophilins |
| REAC:R-HSA-194315 | 0.000501262158212 | 0.8 | RHOA RHOC ARHGEF11 ARHGEF1 | Signaling by Rho GTPases |
| GO:0007266 | 0.000625996400903 | 0.8 | RHOA RHOC ARHGEF11 ARHGEF1 | Rho protein signal transduction |
| KEGG:05130 | 0.000772172961031 | 0.6 | RHOA ARHGEF11 ARHGEF1 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-73887 | 0.000874143100407 | 0.6 | RHOA ARHGEF11 ARHGEF1 | Death Receptor Signalling |
| KEGG:05163 | 0.00114726739179 | 0.6 | RHOA ARHGEF11 ARHGEF1 | Human cytomegalovirus infection |
| REAC:R-HSA-388396 | 0.00122449193088 | 0.8 | RHOA RHOC ARHGEF11 ARHGEF1 | GPCR downstream signalling |
| REAC:R-HSA-372790 | 0.0016972853423 | 0.8 | RHOA RHOC ARHGEF11 ARHGEF1 | Signaling by GPCR |
| REAC:R-HSA-5625900 | 0.00230284247734 | 0.4 | RHOC RHOA | RHO GTPases activate CIT |
| REAC:R-HSA-5627117 | 0.00230284247734 | 0.4 | RHOC RHOA | RHO GTPases Activate ROCKs |
| WP:WP524 | 0.00233629086428 | 0.4 | ARHGEF1 RHOA | G13 Signaling Pathway |
| GO:1902766 | 0.00450823411379 | 0.4 | RHOC RHOA | skeletal muscle satellite cell migration |
| GO:0051056 | 0.0120893245383 | 0.8 | RHOA RHOC ARHGEF11 ARHGEF1 | regulation of small GTPase mediated signal transduction |
| WP:WP35 | 0.0123508080289 | 0.4 | ARHGEF1 RHOA | G Protein Signaling Pathways |
| WP:WP2431 | 0.0129250833235 | 0.4 | RHOC RHOA | Spinal Cord Injury |
| KEGG:05200 | 0.0137388951306 | 0.6 | RHOA ARHGEF11 ARHGEF1 | Pathways in cancer |
| REAC:R-HSA-193648 | 0.0184727645209 | 0.4 | ARHGEF11 ARHGEF1 | NRAGE signals death through JNK |
| WP:WP428 | 0.0186722652698 | 0.4 | RHOA DAAM2 | Wnt Signaling |
| MIRNA:hsa-miR-133a-5p | 0.0192316626023 | 0.4 | RHOC RHOA | hsa-miR-133a-5p |
| WP:WP4217 | 0.0226950547009 | 0.4 | RHOC RHOA | Ebola Virus Pathway on Host |
| KEGG:04611 | 0.0258305316126 | 0.4 | ARHGEF1 RHOA | Platelet activation |
| KEGG:05135 | 0.0262966325762 | 0.4 | ARHGEF1 RHOA | Yersinia infection |
| WP:WP51 | 0.0283719124097 | 0.4 | ARHGEF1 RHOA | Regulation of Actin Cytoskeleton |
| REAC:R-HSA-204998 | 0.0304761248659 | 0.4 | ARHGEF11 ARHGEF1 | Cell death signalling via NRAGE, NRIF and NADE |
| GO:0007265 | 0.0376297096835 | 0.8 | RHOA RHOC ARHGEF11 ARHGEF1 | Ras protein signal transduction |
| KEGG:04310 | 0.0451834163131 | 0.4 | RHOA DAAM2 | Wnt signaling pathway |
| CORUM:553 | 0.0499494897235 | 0.2 | RHOA | RHOA-IP3R-TRPC1 complex |
| CORUM:816 | 0.0499494897235 | 0.2 | RHOA | MRIP-RHOA complex |
| CORUM:3177 | 0.0499494897235 | 0.2 | ARHGEF1 | GNA14-p115RhoGEF complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RHOA | RHOC | 0.92 | 0.844 | bioplex (RHOC) bioplex_WMM |
| DAAM2 | RHOC | 0.05 | 0.295 | bioplex (RHOC) bioplex_WMM |
| ARHGEF11 | RHOA | 0.045 | 0.293 | bioplex (RHOA) bioplex_WMM |
| ARHGEF1 | RHOA | 0.045 | 0.284 | bioplex (RHOA) bioplex_WMM |
| ARHGEF1 | RHOC | 0.027 | 0.232 | bioplex (RHOC) bioplex_WMM |
| ARHGEF11 | RHOC | 0.019 | 0.183 | bioplex (RHOC) bioplex_WMM |
| ARHGEF11 | ARHGEF1 | 0.009 | 0.098 | bioplex_WMM WMM_only |
| DAAM2 | RHOA | 0.008 | 0.066 | bioplex_WMM WMM_only |
| ARHGEF1 | DAAM2 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| ARHGEF11 | DAAM2 | 0.008 | 0.046 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03163 has an average edge precision of 0.239 which is ranked 5545 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RHOA | HuMAP2_03143 HuMAP2_03163 HuMAP2_04764 HuMAP2_05697 |
| RHOC | HuMAP2_03143 HuMAP2_03163 HuMAP2_04764 HuMAP2_05062 HuMAP2_05697 |
| ARHGEF11 | HuMAP2_00703 HuMAP2_02784 HuMAP2_03163 HuMAP2_03420 |
| DAAM2 | HuMAP2_03143 HuMAP2_03163 HuMAP2_05062 HuMAP2_05697 |
| ARHGEF1 | HuMAP2_03143 HuMAP2_03163 HuMAP2_05697 |