hu.MAP 2.0: Complex View

Human Protein Complex Map

Genename	Protein Name	Links
NEFM	Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein)	UniProt NCBI
NEFL	Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein)	UniProt NCBI
INA	Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (NF-66) (Neurofilament-66) (Neurofilament 5)	UniProt NCBI
NES	Nestin	UniProt NCBI
SYNC	Syncoilin (Syncoilin intermediate filament 1) (Syncoilin-1)	UniProt NCBI
SPATA22	Spermatogenesis-associated protein 22 (Testis development protein NYD-SP20)	UniProt NCBI
VIM	Vimentin	UniProt NCBI
DES	Desmin	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0005882	4.59885405516e-09	0.75	NEFM NES DES INA VIM NEFL	intermediate filament
GO:0045111	7.95136252878e-08	0.75	NEFM NES DES INA VIM NEFL	intermediate filament cytoskeleton
GO:0005200	1.98752739757e-05	0.625	NEFM VIM INA DES NEFL	structural constituent of cytoskeleton
GO:0045103	8.88204130675e-05	0.5	NEFM NEFL DES NES	intermediate filament-based process
GO:0045104	8.88204130675e-05	0.5	NEFM NEFL DES NES	intermediate filament cytoskeleton organization
GO:0005883	0.000101639975642	0.375	NEFM INA NEFL	neurofilament
GO:0099513	0.000378731173648	0.75	NEFM NES DES INA VIM NEFL	polymeric cytoskeletal fiber
GO:0099512	0.00234876916508	0.75	NEFM NES DES INA VIM NEFL	supramolecular fiber
GO:0099081	0.00251484937643	0.75	NEFM NES DES INA VIM NEFL	supramolecular polymer
GO:0099080	0.00254345393241	0.75	NEFM NES DES INA VIM NEFL	supramolecular complex
GO:0045109	0.00344619549436	0.375	NEFM NEFL DES	intermediate filament organization
WP:WP4352	0.00764439931257	0.375	NEFM NEFL VIM	Ciliary landscape
WP:WP383	0.00842941151014	0.25	VIM DES	Striated Muscle Contraction Pathway
WP:WP2447	0.0088953208221	0.25	NEFM NEFL	Amyotrophic lateral sclerosis (ALS)
KEGG:05014	0.0152729293192	0.25	NEFM NEFL	Amyotrophic lateral sclerosis (ALS)
WP:WP3680	0.0245464965472	0.25	NEFM NEFL	Association Between Physico-Chemical Features and Toxicity Associated Pathways
REAC:R-HSA-390522	0.0263986242322	0.25	VIM DES	Striated Muscle Contraction
GO:0033693	0.0378589948753	0.25	NEFM NEFL	neurofilament bundle assembly

Protein 1	Protein 2	Score	Precision	Evidence
DES	VIM	0.97	0.881	bioplex (VIM) bioplex_WMM boldt_WMM treiber_WMM
DES	NEFM	0.74	0.739	bioplex (NEFM) bioplex_WMM boldt_WMM
INA	NEFM	0.707	0.729	bioplex (NEFM) bioplex_WMM boldt_WMM
SYNC	DES	0.649	0.688	bioplex (SYNC) bioplex_WMM
NEFM	NEFL	0.447	0.591	bioplex (NEFL,NEFM) bioplex_WMM boldt boldt_WMM
VIM	NEFM	0.358	0.54	bioplex (NEFM,VIM) bioplex_WMM boldt (VIM) boldt_WMM
VIM	NES	0.216	0.464	hein_WMM bioplex (VIM) bioplex_WMM hein (NES) treiber_WMM
NEFM	NES	0.163	0.42	bioplex (NEFM) bioplex_WMM
VIM	INA	0.123	0.394	bioplex (VIM) bioplex_WMM boldt_WMM
VIM	NEFL	0.103	0.366	bioplex (NEFL,VIM) bioplex_WMM boldt (VIM) boldt_WMM
SYNC	VIM	0.057	0.324	hein_WMM bioplex (SYNC,VIM) bioplex_WMM hein (VIM)
SYNC	NEFM	0.045	0.28	bioplex (SYNC) bioplex_WMM
DES	SPATA22	0.042	0.27	bioplex (SPATA22) bioplex_WMM
SYNC	INA	0.025	0.215	bioplex (SYNC) bioplex_WMM
INA	NEFL	0.014	0.14	bioplex_WMM youn_WMM WMM_only boldt_WMM
SYNC	NEFL	0.014	0.144	bioplex (SYNC) bioplex_WMM
DES	INA	0.011	0.143	bioplex_WMM WMM_only boldt_WMM
DES	NES	0.011	0.142	bioplex_WMM WMM_only treiber_WMM
DES	NEFL	0.01	0.14	bioplex_WMM WMM_only boldt_WMM
NEFL	NES	0.01	0.126	bioplex_WMM WMM_only
INA	NES	0.01	0.099	bioplex_WMM WMM_only
SPATA22	VIM	0.007	0.001	bioplex (SPATA22)
SYNC	NES	0.004	0.011	bioplex (SYNC) bioplex_WMM

Click to enlarge

Complex HuMAP2_03169 has an average edge precision of 0.341 which is ranked 4108 out of all 6965 complexes.

Genename	Complexes
NEFM	HuMAP2_01819 HuMAP2_03169 HuMAP2_03286 HuMAP2_04023 HuMAP2_05486 HuMAP2_05674
NEFL	HuMAP2_01819 HuMAP2_03169 HuMAP2_04023 HuMAP2_04987
INA	HuMAP2_01819 HuMAP2_03169 HuMAP2_04023 HuMAP2_05486
NES	HuMAP2_01819 HuMAP2_03169 HuMAP2_04023
SYNC	HuMAP2_00514 HuMAP2_03169 HuMAP2_03286 HuMAP2_03392 HuMAP2_04023 HuMAP2_05229
SPATA22	HuMAP2_01489 HuMAP2_01819 HuMAP2_03169 HuMAP2_04023 HuMAP2_06460
VIM	HuMAP2_01705 HuMAP2_01819 HuMAP2_03169 HuMAP2_03392 HuMAP2_04023 HuMAP2_04747 HuMAP2_05674
DES	HuMAP2_01489 HuMAP2_01819 HuMAP2_03169 HuMAP2_03286 HuMAP2_03392 HuMAP2_04023 HuMAP2_05674 HuMAP2_06460