hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03172
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| JAK1 | Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1) | UniProt NCBI |
| IL4R | Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)] | UniProt NCBI |
| EXPH5 | Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) | UniProt NCBI |
| NET1 | Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8) | UniProt NCBI |
| NCAPH2 | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP395 | 0.00439842637514 | 0.4 | JAK1 IL4R | IL-4 Signaling Pathway |
| KEGG:04658 | 0.0105709544625 | 0.4 | JAK1 IL4R | Th1 and Th2 cell differentiation |
| KEGG:04659 | 0.0155166515839 | 0.4 | JAK1 IL4R | Th17 cell differentiation |
| CORUM:1514 | 0.0249780992026 | 0.2 | IL4R | IL4-IL4R complex |
| KEGG:04630 | 0.030676003082 | 0.4 | JAK1 IL4R | JAK-STAT signaling pathway |
| CORUM:1515 | 0.0499494897235 | 0.2 | IL4R | IL4-IL4R-IL2RG complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NCAPH2 | NET1 | 0.059 | 0.333 | bioplex (NCAPH2) bioplex_WMM |
| JAK1 | IL4R | 0.034 | 0.259 | bioplex (IL4R) bioplex_WMM |
| IL4R | NET1 | 0.033 | 0.253 | bioplex (IL4R) bioplex_WMM |
| NCAPH2 | EXPH5 | 0.028 | 0.231 | bioplex (NCAPH2) bioplex_WMM |
| EXPH5 | NET1 | 0.008 | 0.026 | bioplex_WMM WMM_only |
| JAK1 | NET1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| EXPH5 | JAK1 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| NCAPH2 | JAK1 | 0.006 | 0.008 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03172 has an average edge precision of 0.14 which is ranked 6772 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| JAK1 | HuMAP2_02049 HuMAP2_02815 HuMAP2_03172 |
| IL4R | HuMAP2_02049 HuMAP2_02815 HuMAP2_03172 |
| EXPH5 | HuMAP2_01363 HuMAP2_03172 |
| NET1 | HuMAP2_02815 HuMAP2_03172 HuMAP2_03785 |
| NCAPH2 | HuMAP2_01363 HuMAP2_02781 HuMAP2_03172 |