hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03175
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GAREM2 | GRB2-associated and regulator of MAPK protein 2 (GRB2-associated and regulator of MAPK1-like) | UniProt NCBI |
| SPATA2 | Spermatogenesis-associated protein 2 | UniProt NCBI |
| CBLB | E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) | UniProt NCBI |
| SNX18 | Sorting nexin-18 (SH3 and PX domain-containing protein 3B) (Sorting nexin-associated Golgi protein 1) | UniProt NCBI |
| GRB2 | Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2) | UniProt NCBI |
| ERRFI1 | ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) | UniProt NCBI |
| GLS2 | Glutaminase liver isoform, mitochondrial (GLS) (EC 3.5.1.2) (L-glutaminase) (L-glutamine amidohydrolase) | UniProt NCBI |
| SPATA2L | Spermatogenesis-associated protein 2-like protein (SPATA2-like protein) | UniProt NCBI |
| SOS1 | Son of sevenless homolog 1 (SOS-1) | UniProt NCBI |
| SOS2 | Son of sevenless homolog 2 (SOS-2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP437 | 2.02422274986e-06 | 0.5 | SOS2 CBLB SOS1 ERRFI1 GRB2 | EGF/EGFR Signaling Pathway |
| KEGG:04012 | 7.22425781966e-06 | 0.4 | SOS2 CBLB SOS1 GRB2 | ErbB signaling pathway |
| REAC:R-HSA-8983432 | 1.00000521116e-05 | 0.3 | SOS2 SOS1 GRB2 | Interleukin-15 signaling |
| KEGG:04660 | 1.22421066488e-05 | 0.4 | SOS2 CBLB SOS1 GRB2 | T cell receptor signaling pathway |
| WP:WP673 | 1.26158143816e-05 | 0.4 | SOS2 CBLB SOS1 GRB2 | ErbB Signaling Pathway |
| CORUM:3144 | 3.01890677263e-05 | 0.2 | SOS1 GRB2 | GRB2-SOS1 complex |
| CORUM:2917 | 3.01890677263e-05 | 0.2 | SOS1 GRB2 | GRB2-SOS1 complex |
| CORUM:2893 | 3.01890677263e-05 | 0.2 | SOS1 GRB2 | BCR-ABL (p210 fusion protein)-GRB2-SOS1 complex |
| KEGG:04910 | 4.59088086122e-05 | 0.4 | SOS2 CBLB SOS1 GRB2 | Insulin signaling pathway |
| WP:WP422 | 7.34516383322e-05 | 0.3 | SOS2 SOS1 GRB2 | MAPK Cascade |
| KEGG:05206 | 0.000114200818637 | 0.4 | SOS2 GLS2 SOS1 GRB2 | MicroRNAs in cancer |
| WP:WP481 | 0.000137293138703 | 0.4 | SOS2 CBLB SOS1 GRB2 | Insulin Signaling |
| WP:WP4535 | 0.000177606946834 | 0.3 | SOS2 SOS1 GRB2 | Envelope proteins and their potential roles in EDMD physiopathology |
| CORUM:2922 | 0.000181004688405 | 0.2 | SOS1 GRB2 | LAT-PLC-gamma-1-p85-GRB2-SOS signaling complex, C305 activated |
| REAC:R-HSA-451927 | 0.000223870409604 | 0.3 | SOS2 SOS1 GRB2 | Interleukin-2 family signaling |
| KEGG:04664 | 0.000269919409126 | 0.3 | SOS2 SOS1 GRB2 | Fc epsilon RI signaling pathway |
| KEGG:05213 | 0.000300829621613 | 0.3 | SOS2 SOS1 GRB2 | Endometrial cancer |
| KEGG:05221 | 0.000351452058 | 0.3 | SOS2 SOS1 GRB2 | Acute myeloid leukemia |
| KEGG:04917 | 0.000388151075291 | 0.3 | SOS2 SOS1 GRB2 | Prolactin signaling pathway |
| WP:WP4205 | 0.000390590270259 | 0.3 | SOS2 SOS1 GRB2 | MET in type 1 papillary renal cell carcinoma |
| KEGG:05211 | 0.000407414683827 | 0.3 | SOS2 SOS1 GRB2 | Renal cell carcinoma |
| KEGG:05223 | 0.000427300495861 | 0.3 | SOS2 SOS1 GRB2 | Non-small cell lung cancer |
| KEGG:04662 | 0.000490786933665 | 0.3 | SOS2 SOS1 GRB2 | B cell receptor signaling pathway |
| WP:WP4155 | 0.000503966439829 | 0.3 | SOS2 SOS1 GRB2 | Endometrial cancer |
| KEGG:05214 | 0.000513257270191 | 0.3 | SOS2 SOS1 GRB2 | Glioma |
| CORUM:2480 | 0.000632835990272 | 0.2 | SOS1 GRB2 | CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1) |
| KEGG:05220 | 0.000662481583065 | 0.3 | SOS2 SOS1 GRB2 | Chronic myeloid leukemia |
| KEGG:01521 | 0.000662481583065 | 0.3 | SOS2 SOS1 GRB2 | EGFR tyrosine kinase inhibitor resistance |
| WP:WP4255 | 0.000727373434292 | 0.3 | SOS2 SOS1 GRB2 | Non-small cell lung cancer |
| KEGG:04912 | 0.000869790061312 | 0.3 | SOS2 SOS1 GRB2 | GnRH signaling pathway |
| KEGG:05210 | 0.000902501015727 | 0.3 | SOS2 SOS1 GRB2 | Colorectal cancer |
| WP:WP69 | 0.000969600235273 | 0.3 | CBLB SOS1 GRB2 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| KEGG:04540 | 0.000970338030201 | 0.3 | SOS2 SOS1 GRB2 | Gap junction |
| KEGG:05231 | 0.00115445265122 | 0.3 | SOS2 SOS1 GRB2 | Choline metabolism in cancer |
| KEGG:01522 | 0.00119383922172 | 0.3 | SOS2 SOS1 GRB2 | Endocrine resistance |
| KEGG:05215 | 0.00119383922172 | 0.3 | SOS2 SOS1 GRB2 | Prostate cancer |
| KEGG:04650 | 0.00158884524162 | 0.3 | SOS2 SOS1 GRB2 | Natural killer cell mediated cytotoxicity |
| KEGG:04722 | 0.00200492773446 | 0.3 | SOS2 SOS1 GRB2 | Neurotrophin signaling pathway |
| WP:WP4321 | 0.00212596985033 | 0.3 | SOS2 SOS1 GRB2 | Thermogenesis |
| WP:WP710 | 0.00239084917209 | 0.3 | SOS2 SOS1 GRB2 | DNA Damage Response (only ATM dependent) |
| KEGG:04068 | 0.00242295667073 | 0.3 | SOS2 SOS1 GRB2 | FoxO signaling pathway |
| KEGG:04926 | 0.00282379100671 | 0.3 | SOS2 SOS1 GRB2 | Relaxin signaling pathway |
| KEGG:04630 | 0.00289455783846 | 0.3 | SOS2 SOS1 GRB2 | JAK-STAT signaling pathway |
| KEGG:04915 | 0.0029664799332 | 0.3 | SOS2 SOS1 GRB2 | Estrogen signaling pathway |
| KEGG:04072 | 0.00326589651874 | 0.3 | SOS2 SOS1 GRB2 | Phospholipase D signaling pathway |
| KEGG:05224 | 0.00358449801405 | 0.3 | SOS2 SOS1 GRB2 | Breast cancer |
| KEGG:04062 | 0.00358449801405 | 0.3 | SOS2 SOS1 GRB2 | Chemokine signaling pathway |
| KEGG:05226 | 0.00366721137019 | 0.3 | SOS2 SOS1 GRB2 | Gastric cancer |
| WP:WP3915 | 0.00404291892122 | 0.3 | CBLB SOS1 SOS2 | Angiopoietin Like Protein 8 Regulatory Pathway |
| WP:WP3929 | 0.00404291892122 | 0.3 | SOS2 SOS1 GRB2 | Chemokine signaling pathway |
| KEGG:05160 | 0.0040995893152 | 0.3 | SOS2 SOS1 GRB2 | Hepatitis C |
| KEGG:04150 | 0.00485869437933 | 0.3 | SOS2 SOS1 GRB2 | mTOR signaling pathway |
| WP:WP4239 | 0.00520724077075 | 0.3 | SOS2 SOS1 GRB2 | Epithelial to mesenchymal transition in colorectal cancer |
| WP:WP4262 | 0.00567958855327 | 0.3 | SOS2 SOS1 GRB2 | Breast cancer pathway |
| KEGG:05161 | 0.00604483703064 | 0.3 | SOS2 SOS1 GRB2 | Hepatitis B |
| WP:WP4666 | 0.00643941287095 | 0.3 | SOS2 SOS1 GRB2 | Hepatitis B infection |
| KEGG:05225 | 0.00651897348671 | 0.3 | SOS2 SOS1 GRB2 | Hepatocellular carcinoma |
| REAC:R-HSA-428540 | 0.00659484253239 | 0.2 | SOS1 SOS2 | Activation of RAC1 |
| KEGG:05034 | 0.00740600690315 | 0.3 | SOS2 SOS1 GRB2 | Alcoholism |
| WP:WP4223 | 0.0078484775429 | 0.3 | SOS2 SOS1 GRB2 | Ras Signaling |
| WP:WP581 | 0.00816086245592 | 0.2 | SOS1 GRB2 | EPO Receptor Signaling |
| WP:WP2643 | 0.00948491249007 | 0.2 | SOS1 GRB2 | Nanoparticle-mediated activation of receptor signaling |
| KEGG:04014 | 0.0100396314587 | 0.3 | SOS2 SOS1 GRB2 | Ras signaling pathway |
| WP:WP3972 | 0.0101838495911 | 0.2 | SOS1 GRB2 | PDGFR-beta pathway |
| KEGG:05205 | 0.0106972943022 | 0.3 | SOS2 SOS1 GRB2 | Proteoglycans in cancer |
| KEGG:04510 | 0.0108659777473 | 0.3 | SOS2 SOS1 GRB2 | Focal adhesion |
| WP:WP3676 | 0.0124279889213 | 0.2 | SOS1 GRB2 | BDNF-TrkB Signaling |
| KEGG:05163 | 0.0132185144954 | 0.3 | SOS2 SOS1 GRB2 | Human cytomegalovirus infection |
| WP:WP244 | 0.0132250558427 | 0.2 | SOS1 GRB2 | Alpha 6 Beta 4 signaling pathway |
| WP:WP3981 | 0.0132250558427 | 0.2 | SOS1 GRB2 | miRNA regulation of prostate cancer signaling pathways |
| WP:WP313 | 0.0140465886183 | 0.2 | SOS1 GRB2 | Signaling of Hepatocyte Growth Factor Receptor |
| KEGG:04714 | 0.0146119003934 | 0.3 | SOS2 SOS1 GRB2 | Thermogenesis |
| GO:0007173 | 0.0151751466558 | 0.4 | CBLB SOS1 ERRFI1 GRB2 | epidermal growth factor receptor signaling pathway |
| WP:WP127 | 0.0175768464916 | 0.2 | SOS1 GRB2 | IL-5 Signaling Pathway |
| WP:WP2526 | 0.0194880797793 | 0.2 | SOS1 GRB2 | PDGF Pathway |
| WP:WP49 | 0.0194880797793 | 0.2 | SOS1 GRB2 | IL-2 Signaling Pathway |
| WP:WP364 | 0.0214964332109 | 0.2 | SOS1 GRB2 | IL-6 signaling pathway |
| WP:WP286 | 0.0214964332109 | 0.2 | SOS1 GRB2 | IL-3 Signaling Pathway |
| WP:WP382 | 0.0217644056226 | 0.3 | SOS2 SOS1 GRB2 | MAPK Signaling Pathway |
| WP:WP3646 | 0.0246906006348 | 0.2 | SOS1 GRB2 | Hepatitis C and Hepatocellular Carcinoma |
| KEGG:04010 | 0.0264785085069 | 0.3 | SOS2 SOS1 GRB2 | MAPK signaling pathway |
| HP:0011381 | 0.0266406279253 | 0.2 | SOS1 SOS2 | Aplasia of the semicircular canal |
| WP:WP3863 | 0.0304968190482 | 0.2 | SOS1 GRB2 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| WP:WP395 | 0.032987603829 | 0.2 | SOS1 GRB2 | IL-4 Signaling Pathway |
| GO:0038127 | 0.0329917100529 | 0.4 | CBLB SOS1 ERRFI1 GRB2 | ERBB signaling pathway |
| WP:WP304 | 0.0382565269801 | 0.2 | SOS1 GRB2 | Kit receptor signaling pathway |
| KEGG:04151 | 0.0420237476017 | 0.3 | SOS2 SOS1 GRB2 | PI3K-Akt signaling pathway |
| HP:0011380 | 0.0447272498042 | 0.2 | SOS1 SOS2 | Morphological abnormality of the semicircular canal |
| KEGG:05165 | 0.047087803646 | 0.3 | SOS2 SOS1 GRB2 | Human papillomavirus infection |
| WP:WP4172 | 0.0479719964262 | 0.3 | SOS2 SOS1 GRB2 | PI3K-Akt Signaling Pathway |
| WP:WP3680 | 0.0483946984354 | 0.2 | SOS1 GRB2 | Association Between Physico-Chemical Features and Toxicity Associated Pathways |
| WP:WP2374 | 0.0499379210576 | 0.2 | SOS1 GRB2 | Oncostatin M Signaling Pathway |
| CORUM:2892 | 0.0499561984052 | 0.1 | GRB2 | BCR-ABL (p185 fusion protein)-GRB2 complex |
| CORUM:2540 | 0.0499561984052 | 0.1 | GRB2 | BCR-ABL (p210 fusion protein)-GRB2 complex |
| CORUM:2957 | 0.0499561984052 | 0.1 | GRB2 | LAT-GRB2 complex, Fyn-mLck(KA) or Syk kinase activated |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GRB2 | ERRFI1 | 1.0 | 0.949 | bioplex (GRB2) bioplex_WMM |
| SOS1 | GRB2 | 0.994 | 0.92 | bioplex (GRB2) bioplex_WMM |
| GRB2 | SOS2 | 0.983 | 0.899 | bioplex (GRB2) bioplex_WMM |
| GRB2 | GLS2 | 0.956 | 0.862 | bioplex (GRB2) bioplex_WMM |
| GRB2 | SPATA2L | 0.94 | 0.852 | bioplex (GRB2) bioplex_WMM gupta_WMM |
| CBLB | GRB2 | 0.847 | 0.79 | bioplex (GRB2) bioplex_WMM |
| GRB2 | GAREM2 | 0.229 | 0.469 | bioplex (GRB2) bioplex_WMM |
| SPATA2 | GRB2 | 0.037 | 0.266 | bioplex (GRB2) bioplex_WMM gupta_WMM |
| SNX18 | GRB2 | 0.029 | 0.23 | bioplex (GRB2) bioplex_WMM |
| SPATA2 | SPATA2L | 0.009 | 0.109 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SOS2 | GAREM2 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| ERRFI1 | GLS2 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| GLS2 | SPATA2L | 0.009 | 0.095 | bioplex_WMM WMM_only |
| SOS1 | GAREM2 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| SOS1 | SPATA2L | 0.009 | 0.095 | bioplex_WMM WMM_only |
| SOS2 | GLS2 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| GAREM2 | GLS2 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| SOS2 | SPATA2L | 0.009 | 0.095 | bioplex_WMM WMM_only |
| SOS1 | GLS2 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| ERRFI1 | SPATA2L | 0.009 | 0.095 | bioplex_WMM WMM_only |
| ERRFI1 | GAREM2 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| SOS1 | ERRFI1 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| SOS1 | SOS2 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| ERRFI1 | SOS2 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| GAREM2 | SPATA2L | 0.009 | 0.095 | bioplex_WMM WMM_only |
| CBLB | ERRFI1 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| SPATA2 | GAREM2 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| CBLB | SPATA2L | 0.008 | 0.091 | bioplex_WMM WMM_only |
| SPATA2 | ERRFI1 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| SPATA2 | GLS2 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| SPATA2 | SOS1 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| CBLB | GAREM2 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| SPATA2 | SOS2 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| CBLB | SOS2 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| CBLB | GLS2 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| CBLB | SOS1 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| SPATA2 | CBLB | 0.008 | 0.085 | bioplex_WMM WMM_only |
| SNX18 | SPATA2L | 0.008 | 0.06 | bioplex_WMM youn_WMM WMM_only |
| SNX18 | SOS1 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| SNX18 | ERRFI1 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| SNX18 | SOS2 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| SNX18 | GAREM2 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| SNX18 | GLS2 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| SPATA2 | SNX18 | 0.008 | 0.041 | bioplex_WMM youn_WMM WMM_only |
| SNX18 | CBLB | 0.008 | 0.025 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03175 has an average edge precision of 0.206 which is ranked 6085 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GAREM2 | HuMAP2_03175 |
| SPATA2 | HuMAP2_00373 HuMAP2_02980 HuMAP2_03175 HuMAP2_03640 HuMAP2_06270 HuMAP2_06640 |
| CBLB | HuMAP2_03175 HuMAP2_04106 |
| SNX18 | HuMAP2_02352 HuMAP2_03018 HuMAP2_03175 |
| GRB2 | HuMAP2_03175 |
| ERRFI1 | HuMAP2_03175 |
| GLS2 | HuMAP2_03175 |
| SPATA2L | HuMAP2_03175 |
| SOS1 | HuMAP2_03175 |
| SOS2 | HuMAP2_03175 |