hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03186
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| EXOC1 | Exocyst complex component 1 (Exocyst complex component Sec3) | UniProt NCBI |
| EXOC4 | Exocyst complex component 4 (Exocyst complex component Sec8) | UniProt NCBI |
| EXOC2 | Exocyst complex component 2 (Exocyst complex component Sec5) | UniProt NCBI |
| GCC2 | GRIP and coiled-coil domain-containing protein 2 (185 kDa Golgi coiled-coil protein) (GCC185) (CLL-associated antigen KW-11) (CTCL tumor antigen se1-1) (Ran-binding protein 2-like 4) (RanBP2L4) (Renal carcinoma antigen NY-REN-53) | UniProt NCBI |
| EXOC3 | Exocyst complex component 3 (Exocyst complex component Sec6) | UniProt NCBI |
| TRIP11 | Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:89 | 3.17671592963e-11 | 0.666666666667 | EXOC3 EXOC2 EXOC1 EXOC4 | Exocyst Sec6/8 complex |
| CORUM:6167 | 3.17671592963e-11 | 0.666666666667 | EXOC3 EXOC2 EXOC1 EXOC4 | Exocyst complex |
| REAC:R-HSA-5620916 | 4.64286129501e-09 | 0.666666666667 | EXOC3 EXOC2 EXOC1 EXOC4 | VxPx cargo-targeting to cilium |
| REAC:R-HSA-264876 | 1.27214964402e-08 | 0.666666666667 | EXOC3 EXOC2 EXOC1 EXOC4 | Insulin processing |
| REAC:R-HSA-5620920 | 2.13011432628e-07 | 0.666666666667 | EXOC3 EXOC2 EXOC1 EXOC4 | Cargo trafficking to the periciliary membrane |
| GO:0000145 | 2.61389419879e-07 | 0.666666666667 | EXOC3 EXOC2 EXOC1 EXOC4 | exocyst |
| REAC:R-HSA-5617833 | 3.20449539048e-07 | 0.833333333333 | EXOC3 EXOC2 TRIP11 EXOC1 EXOC4 | Cilium Assembly |
| REAC:R-HSA-199991 | 5.63440851629e-07 | 1.0 | TRIP11 EXOC1 EXOC4 EXOC2 GCC2 EXOC3 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 7.78293352237e-07 | 1.0 | TRIP11 EXOC1 EXOC4 EXOC2 GCC2 EXOC3 | Vesicle-mediated transport |
| REAC:R-HSA-1445148 | 9.70376566633e-07 | 0.666666666667 | EXOC3 EXOC2 EXOC1 EXOC4 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| REAC:R-HSA-2980736 | 1.02998099357e-06 | 0.666666666667 | EXOC3 EXOC2 EXOC1 EXOC4 | Peptide hormone metabolism |
| REAC:R-HSA-1852241 | 2.15632898754e-06 | 0.833333333333 | EXOC3 EXOC2 TRIP11 EXOC1 EXOC4 | Organelle biogenesis and maintenance |
| WP:WP4352 | 2.41896743887e-05 | 0.666666666667 | EXOC3 EXOC2 EXOC1 EXOC4 | Ciliary landscape |
| GO:0099023 | 0.000133653758006 | 0.666666666667 | EXOC3 EXOC2 EXOC1 EXOC4 | vesicle tethering complex |
| GO:0044448 | 0.00506594708818 | 0.666666666667 | EXOC3 EXOC2 EXOC1 EXOC4 | cell cortex part |
| GO:0005938 | 0.0222594167129 | 0.666666666667 | EXOC3 EXOC2 EXOC1 EXOC4 | cell cortex |
| GO:0006893 | 0.0353486827187 | 0.5 | EXOC2 EXOC1 EXOC4 | Golgi to plasma membrane transport |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EXOC1 | EXOC2 | 1.0 | 0.949 | bioplex (EXOC1) bioplex_WMM boldt (EXOC1,EXOC2) Malo fraction boldt_WMM |
| EXOC4 | EXOC2 | 1.0 | 0.949 | bioplex_WMM boldt (EXOC2,EXOC4) youn_WMM Malo fraction boldt_WMM treiber_WMM |
| EXOC1 | EXOC4 | 0.999 | 0.949 | bioplex (EXOC1) bioplex_WMM boldt (EXOC1,EXOC4) Malo fraction boldt_WMM |
| EXOC4 | EXOC3 | 0.998 | 0.943 | bioplex (EXOC3) bioplex_WMM boldt (EXOC3,EXOC4) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| TRIP11 | EXOC3 | 0.994 | 0.921 | bioplex (EXOC3) bioplex_WMM boldt (EXOC3) gupta_WMM boldt_WMM |
| EXOC2 | EXOC3 | 0.99 | 0.909 | bioplex (EXOC3) bioplex_WMM boldt (EXOC2,EXOC3) Malo fraction boldt_WMM treiber_WMM |
| EXOC1 | EXOC3 | 0.988 | 0.902 | bioplex (EXOC1,EXOC3) bioplex_WMM boldt (EXOC1,EXOC3) Malo fraction boldt_WMM |
| GCC2 | EXOC3 | 0.903 | 0.827 | bioplex (EXOC3) bioplex_WMM boldt (EXOC3) boldt_WMM |
| TRIP11 | EXOC2 | 0.007 | 0.007 | bioplex_WMM boldt boldt_WMM |
| TRIP11 | EXOC4 | 0.007 | 0.008 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| EXOC1 | TRIP11 | 0.007 | 0.006 | bioplex_WMM boldt boldt_WMM |
| TRIP11 | GCC2 | 0.007 | 0.006 | bioplex_WMM boldt youn_WMM boldt_WMM |
| GCC2 | EXOC2 | 0.0 | 0.013 | bioplex_WMM boldt fraction boldt_WMM |
| EXOC1 | GCC2 | 0.0 | 0.009 | bioplex_WMM boldt fraction boldt_WMM |
| GCC2 | EXOC4 | 0.0 | 0.009 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_03186 has an average edge precision of 0.494 which is ranked 2532 out of all 6965 complexes.
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