hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03210
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SUMF1 | Formylglycine-generating enzyme (FGE) (EC 1.8.3.7) (C-alpha-formylglycine-generating enzyme 1) (Sulfatase-modifying factor 1) | UniProt NCBI |
| ARSA | Arylsulfatase A (ASA) (EC 3.1.6.8) (Cerebroside-sulfatase) [Cleaved into: Arylsulfatase A component B; Arylsulfatase A component C] | UniProt NCBI |
| GALNS | N-acetylgalactosamine-6-sulfatase (EC 3.1.6.4) (Chondroitinsulfatase) (Chondroitinase) (Galactose-6-sulfate sulfatase) (GalN6S) (N-acetylgalactosamine-6-sulfate sulfatase) (GalNAc6S sulfatase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04142 | 8.02679835688e-06 | 1.0 | ARSA SUMF1 GALNS | Lysosome |
| REAC:R-HSA-1663150 | 0.000301184970683 | 0.666666666667 | ARSA SUMF1 | The activation of arylsulfatases |
| HP:0008155 | 0.000927625684184 | 0.666666666667 | SUMF1 GALNS | Mucopolysacchariduria |
| HP:0003541 | 0.000927625684184 | 0.666666666667 | SUMF1 GALNS | Urinary glycosaminoglycan excretion |
| HP:0002922 | 0.00185475275658 | 0.666666666667 | ARSA SUMF1 | Increased CSF protein |
| HP:0025456 | 0.00204013662007 | 0.666666666667 | ARSA SUMF1 | Abnormal CSF protein level |
| REAC:R-HSA-163841 | 0.00397787610966 | 0.666666666667 | ARSA SUMF1 | Gamma carboxylation, hypusine formation and arylsulfatase activation |
| REAC:R-HSA-1660662 | 0.00521352578002 | 0.666666666667 | ARSA SUMF1 | Glycosphingolipid metabolism |
| HP:0011096 | 0.00620427636329 | 0.666666666667 | ARSA SUMF1 | Peripheral demyelination |
| HP:0002344 | 0.0068832170429 | 0.666666666667 | ARSA SUMF1 | Progressive neurologic deterioration |
| HP:0008518 | 0.0121532611158 | 0.666666666667 | SUMF1 GALNS | Aplasia/Hypoplasia involving the vertebral column |
| HP:0002518 | 0.0161338784795 | 0.666666666667 | ARSA SUMF1 | Abnormality of the periventricular white matter |
| REAC:R-HSA-428157 | 0.0180259784934 | 0.666666666667 | ARSA SUMF1 | Sphingolipid metabolism |
| HP:0003130 | 0.0307019877242 | 0.666666666667 | ARSA SUMF1 | Abnormal peripheral myelination |
| HP:0003134 | 0.041834410056 | 0.666666666667 | ARSA SUMF1 | Abnormality of peripheral nerve conduction |
| HP:0045010 | 0.044442515366 | 0.666666666667 | ARSA SUMF1 | Abnormality of peripheral nerves |
| REAC:R-HSA-2206290 | 0.0498572752401 | 0.333333333333 | GALNS | MPS IV - Morquio syndrome A |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ARSA | GALNS | 0.918 | 0.841 | bioplex (ARSA) bioplex_WMM |
| ARSA | SUMF1 | 0.605 | 0.672 | bioplex (ARSA) bioplex_WMM |
| GALNS | SUMF1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03210 has an average edge precision of 0.506 which is ranked 2467 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SUMF1 | HuMAP2_00451 HuMAP2_02252 HuMAP2_03210 |
| ARSA | HuMAP2_00018 HuMAP2_02252 HuMAP2_03210 HuMAP2_07005 |
| GALNS | HuMAP2_00018 HuMAP2_03210 HuMAP2_07005 |