hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_03216

Confidence: Medium

Genename	Protein Name	Links
GNAS	Neuroendocrine secretory protein 55 (NESP55) [Cleaved into: LHAL tetrapeptide; GPIPIRRH peptide]	UniProt NCBI
OCIAD1	OCIA domain-containing protein 1 (Ovarian cancer immunoreactive antigen domain containing 1) (Ovarian carcinoma immunoreactive antigen)	UniProt NCBI
TRO	Trophinin (MAGE-D3 antigen)	UniProt NCBI
MAGED2	Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen)	UniProt NCBI
GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	UniProt NCBI
RIC8B	Synembryn-B (Brain synembryn) (hSyn) (Protein Ric-8B)	UniProt NCBI
GNA12	Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12)	UniProt NCBI
GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2)	UniProt NCBI
GNAL	Guanine nucleotide-binding protein G(olf) subunit alpha (Adenylate cyclase-stimulating G alpha protein, olfactory type)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:7188	6.30476064954e-09	0.333333333333	GNAS GNB2 GNG10	GNAS-L-GNB2-GNG10 complex
WP:WP35	4.48427962261e-08	0.555555555556	GNG10 GNAS GNAL GNB2 GNA12	G Protein Signaling Pathways
CORUM:7143	1.34129279418e-05	0.222222222222	GNAS GNB2	GNAS-L-GNB2-GNG1 complex
REAC:R-HSA-392851	2.05802714271e-05	0.333333333333	GNAS GNB2 GNG10	Prostacyclin signalling through prostacyclin receptor
KEGG:04728	2.58990411879e-05	0.444444444444	GNG10 GNAS GNB2 GNAL	Dopaminergic synapse
REAC:R-HSA-420092	4.02039297847e-05	0.333333333333	GNAS GNB2 GNG10	Glucagon-type ligand receptors
CORUM:7189	4.02261743042e-05	0.222222222222	GNAS GNG10	GNAS-L-GNB3-GNG10 complex
CORUM:7171	4.02261743042e-05	0.222222222222	GNAS GNB2	GNAS-L-GNB2-GNG7 complex
CORUM:7148	4.02261743042e-05	0.222222222222	GNAS GNB2	GNAS-L-GNB2-GNG2 complex
CORUM:7166	4.02261743042e-05	0.222222222222	GNAS GNB2	GNAS-L-GNB2-GNG5 complex
CORUM:7193	4.02261743042e-05	0.222222222222	GNAS GNG10	GNAS-L-GNB4-GNG10 complex
CORUM:7194	4.02261743042e-05	0.222222222222	GNAS GNG10	GNAS-L-GNB5-GNG10 complex
CORUM:7077	4.02261743042e-05	0.222222222222	GNB2 GNG10	GNAI1-GNB2-GNG10 complex
CORUM:7161	4.02261743042e-05	0.222222222222	GNAS GNB2	GNAS-L-GNB2-GNG4 complex
CORUM:7153	4.02261743042e-05	0.222222222222	GNAS GNB2	GNAS-L-GNB2-GNG3 complex
CORUM:7199	4.02261743042e-05	0.222222222222	GNAS GNB2	GNAS-L-GNB2-GNG11 complex
CORUM:7205	4.02261743042e-05	0.222222222222	GNAS GNB2	GNAS-L-GNB2-GNG12 complex
CORUM:7210	4.02261743042e-05	0.222222222222	GNAS GNB2	GNAS-L-GNB2-GNG13 complex
CORUM:7187	4.02261743042e-05	0.222222222222	GNAS GNG10	GNAS-L-GNB1-GNG10 complex
CORUM:7176	4.02261743042e-05	0.222222222222	GNAS GNB2	GNAS-L-GNB2-GNG8 complex
GO:1905360	4.56829686442e-05	0.444444444444	GNG10 GNAS GNAL GNA12	GTPase complex
GO:0005834	4.56829686442e-05	0.444444444444	GNG10 GNAS GNAL GNA12	heterotrimeric G-protein complex
REAC:R-HSA-456926	9.8819187137e-05	0.333333333333	GNA12 GNB2 GNG10	Thrombin signalling through proteinase activated receptors (PARs)
REAC:R-HSA-163359	0.000135466824601	0.333333333333	GNAS GNB2 GNG10	Glucagon signaling in metabolic regulation
REAC:R-HSA-977444	0.000149435419153	0.333333333333	GNG10 GNB2 GNAL	GABA B receptor activation
REAC:R-HSA-991365	0.000149435419153	0.333333333333	GNG10 GNB2 GNAL	Activation of GABAB receptors
REAC:R-HSA-381676	0.000197009576918	0.333333333333	GNAS GNB2 GNG10	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
KEGG:05163	0.000200817023016	0.444444444444	GNG10 GNAS GNB2 GNA12	Human cytomegalovirus infection
REAC:R-HSA-432040	0.000233741537372	0.333333333333	GNAS GNB2 GNG10	Vasopressin regulates renal water homeostasis via Aquaporins
REAC:R-HSA-445717	0.000274758240758	0.333333333333	GNAS GNB2 GNG10	Aquaporin-mediated transport
REAC:R-HSA-418597	0.000397570429893	0.333333333333	GNAS GNB2 GNG10	G alpha (z) signalling events
REAC:R-HSA-418555	0.000451643631411	0.444444444444	GNG10 GNAS GNB2 GNAL	G alpha (s) signalling events
REAC:R-HSA-977443	0.000455411282245	0.333333333333	GNG10 GNB2 GNAL	GABA receptor activation
KEGG:05032	0.000650666735719	0.333333333333	GNAS GNB2 GNG10	Morphine addiction
KEGG:04713	0.000835094366543	0.333333333333	GNAS GNB2 GNG10	Circadian entrainment
KEGG:04726	0.00105110969134	0.333333333333	GNAS GNB2 GNG10	Serotonergic synapse
REAC:R-HSA-373080	0.00112914519218	0.333333333333	GNAS GNB2 GNG10	Class B/2 (Secretin family receptors)
REAC:R-HSA-76002	0.00115768487299	0.444444444444	GNG10 GNA12 GNB2 MAGED2	Platelet activation, signaling and aggregation
KEGG:04724	0.00122607355355	0.333333333333	GNAS GNB2 GNG10	Glutamatergic synapse
REAC:R-HSA-109582	0.00131902915988	0.555555555556	GNG10 GNAS MAGED2 GNB2 GNA12	Hemostasis
REAC:R-HSA-388396	0.00134329753933	0.555555555556	GNG10 GNAS GNAL GNB2 GNA12	GPCR downstream signalling
REAC:R-HSA-422356	0.00156095030356	0.333333333333	GNAS GNB2 GNG10	Regulation of insulin secretion
REAC:R-HSA-416482	0.00185073287359	0.333333333333	GNA12 GNB2 GNG10	G alpha (12/13) signalling events
REAC:R-HSA-372790	0.00200613858709	0.555555555556	GNG10 GNAS GNAL GNB2 GNA12	Signaling by GPCR
KEGG:04926	0.00211656132668	0.333333333333	GNAS GNB2 GNG10	Relaxin signaling pathway
REAC:R-HSA-418594	0.00215858652987	0.444444444444	GNG10 GNAS GNB2 GNAL	G alpha (i) signalling events
REAC:R-HSA-418346	0.00217404889806	0.333333333333	GNAS GNB2 GNG10	Platelet homeostasis
REAC:R-HSA-111885	0.00303330403098	0.333333333333	GNG10 GNB2 GNAL	Opioid Signalling
GO:0031234	0.00407883187879	0.444444444444	GNG10 GNAS GNAL GNA12	extrinsic component of cytoplasmic side of plasma membrane
GO:0031683	0.00425534967499	0.333333333333	GNAS GNAL GNA12	G-protein beta/gamma-subunit complex binding
REAC:R-HSA-163685	0.00435549690598	0.333333333333	GNAS GNB2 GNG10	Integration of energy metabolism
KEGG:05200	0.0053385061568	0.444444444444	GNG10 GNAS GNB2 GNA12	Pathways in cancer
KEGG:05034	0.0055640399991	0.333333333333	GNAS GNB2 GNG10	Alcoholism
GO:0003924	0.00704544173438	0.555555555556	GNG10 GNAS GNAL GNB2 GNA12	GTPase activity
REAC:R-HSA-8964315	0.00772521789112	0.222222222222	GNB2 GNG10	G beta:gamma signalling through BTK
GO:0007186	0.00791460243828	0.666666666667	GNG10 GNA12 GNB2 RIC8B GNAL GNAS	G protein-coupled receptor signaling pathway
REAC:R-HSA-997272	0.00984347966308	0.222222222222	GNB2 GNG10	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
REAC:R-HSA-1296041	0.00984347966308	0.222222222222	GNB2 GNG10	Activation of G protein gated Potassium channels
REAC:R-HSA-8964616	0.00984347966308	0.222222222222	GNB2 GNG10	G beta:gamma signalling through CDC42
REAC:R-HSA-418217	0.00984347966308	0.222222222222	GNB2 GNG10	G beta:gamma signalling through PLC beta
REAC:R-HSA-1296059	0.00984347966308	0.222222222222	GNB2 GNG10	G protein gated Potassium channels
HP:0012049	0.0101181244364	0.222222222222	GNAS GNAL	Laryngeal dystonia
REAC:R-HSA-500657	0.010998087958	0.222222222222	GNB2 GNG10	Presynaptic function of Kainate receptors
REAC:R-HSA-392170	0.0122162676274	0.222222222222	GNB2 GNG10	ADP signalling through P2Y purinoceptor 12
REAC:R-HSA-392451	0.0134979585429	0.222222222222	GNB2 GNG10	G beta:gamma signalling through PI3Kgamma
REAC:R-HSA-428930	0.0134979585429	0.222222222222	GNB2 GNG10	Thromboxane signalling through TP receptor
REAC:R-HSA-418592	0.0148431006129	0.222222222222	GNB2 GNG10	ADP signalling through P2Y purinoceptor 1
REAC:R-HSA-1296065	0.0162516337822	0.222222222222	GNB2 GNG10	Inwardly rectifying K+ channels
REAC:R-HSA-202040	0.0208569798789	0.222222222222	GNB2 GNG10	G-protein activation
REAC:R-HSA-400042	0.0208569798789	0.222222222222	GNB2 GNG10	Adrenaline,noradrenaline inhibits insulin secretion
REAC:R-HSA-451326	0.0225184776205	0.222222222222	GNB2 GNG10	Activation of kainate receptors upon glutamate binding
KEGG:04730	0.0225278542333	0.222222222222	GNAS GNA12	Long-term depression
REAC:R-HSA-397795	0.0242430667307	0.222222222222	GNB2 GNG10	G-protein beta:gamma signalling
REAC:R-HSA-112314	0.025329151298	0.333333333333	GNG10 GNB2 GNAL	Neurotransmitter receptors and postsynaptic signal transmission
REAC:R-HSA-392518	0.0260306873727	0.222222222222	GNB2 GNG10	Signal amplification
GO:0019897	0.0279191863549	0.444444444444	GNG10 GNAS GNAL GNA12	extrinsic component of plasma membrane
GO:0009898	0.0317143436917	0.444444444444	GNG10 GNAS GNAL GNA12	cytoplasmic side of plasma membrane
WP:WP2032	0.0396376262126	0.222222222222	GNAS GNA12	Human Thyroid Stimulating Hormone (TSH) signaling pathway
REAC:R-HSA-500792	0.0428229045949	0.333333333333	GNAS GNB2 GNG10	GPCR ligand binding
REAC:R-HSA-6814122	0.0473604898263	0.222222222222	GNB2 GNG10	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
CORUM:7015	0.0499262710315	0.111111111111	GNB2	GNAI1-GNB2-GNGT1 complex
CORUM:7146	0.0499262710315	0.111111111111	GNAS	GNAS-L-GNB1-GNG1 complex
CORUM:7145	0.0499262710315	0.111111111111	GNAS	GNAS-L-GNB4-GNG1 complex
CORUM:7144	0.0499262710315	0.111111111111	GNAS	GNAS-L-GNB3-GNG1 complex
CORUM:3110	0.0499262710315	0.111111111111	GNA12	ITGAV-P2RY2-GNA12 complex
CORUM:7097	0.0499262710315	0.111111111111	GNAS	GNAS-L-GNB1-GNG1 complex
KEGG:04727	0.0499598185166	0.222222222222	GNB2 GNG10	GABAergic synapse

Edges

Protein 1	Protein 2	Score	Precision	Evidence
GNAS	GNAL	1.0	0.949	bioplex (GNAS) bioplex_WMM gupta_WMM boldt_WMM
GNAS	MAGED2	0.993	0.918	bioplex (GNAS,MAGED2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
GNAS	OCIAD1	0.602	0.67	bioplex (GNAS) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
GNAS	GNB2	0.432	0.578	hein_WMM bioplex (GNAS,GNB2) bioplex_WMM youn_WMM
GNAS	GNA12	0.296	0.496	bioplex (GNAS) bioplex_WMM
GNAS	TRO	0.129	0.399	bioplex (GNAS) bioplex_WMM youn_WMM
GNAS	GNG10	0.088	0.353	bioplex (GNAS) bioplex_WMM
MAGED2	GNAL	0.03	0.233	bioplex (MAGED2) bioplex_WMM gupta_WMM boldt_WMM
MAGED2	RIC8B	0.028	0.231	bioplex (MAGED2,RIC8B) bioplex_WMM youn_WMM
GNA12	GNG10	0.009	0.092	bioplex_WMM WMM_only
GNAL	GNA12	0.009	0.1	bioplex_WMM WMM_only
GNAL	GNG10	0.008	0.06	bioplex_WMM WMM_only
GNAL	TRO	0.008	0.019	bioplex_WMM WMM_only
GNAL	GNB2	0.007	0.014	bioplex_WMM WMM_only
GNA12	TRO	0.007	0.013	bioplex_WMM WMM_only
MAGED2	GNA12	0.007	0.003	bioplex_WMM WMM_only
GNAL	OCIAD1	0.007	0.008	bioplex_WMM WMM_only
GNB2	GNA12	0.007	0.005	bioplex_WMM WMM_only
OCIAD1	GNA12	0.007	0.008	bioplex_WMM WMM_only
GNAL	RIC8B	0.007	0.001	bioplex_WMM WMM_only
TRO	GNG10	0.007	0.003	bioplex_WMM WMM_only
MAGED2	GNG10	0.007	0.006	bioplex_WMM WMM_only
RIC8B	GNA12	0.007	0.003	bioplex_WMM WMM_only
GNAS	RIC8B	0.007	0.007	bioplex (RIC8B) bioplex_WMM youn_WMM
MAGED2	TRO	0.007	0.007	bioplex_WMM WMM_only
OCIAD1	GNG10	0.007	0.003	bioplex_WMM WMM_only
GNB2	GNG10	0.007	0.005	bioplex_WMM WMM_only
RIC8B	GNG10	0.006	0.006	bioplex_WMM WMM_only
OCIAD1	TRO	0.006	0.004	bioplex_WMM WMM_only
RIC8B	TRO	0.006	0.005	bioplex_WMM WMM_only
GNB2	TRO	0.006	0.008	bioplex_WMM WMM_only
GNB2	RIC8B	0.006	0.003	bioplex_WMM WMM_only
OCIAD1	RIC8B	0.006	0.007	bioplex_WMM WMM_only
MAGED2	GNB2	0.006	0.005	bioplex_WMM WMM_only
OCIAD1	GNB2	0.006	0.004	hein_WMM bioplex_WMM boldt boldt_WMM
MAGED2	OCIAD1	0.004	0.008	bioplex (MAGED2) bioplex_WMM boldt youn_WMM boldt_WMM

Images

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Complex HuMAP2_03216 has an average edge precision of 0.145 which is ranked 6736 out of all 6965 complexes.

Related Complexes

Genename	Complexes
GNAS	HuMAP2_00029 HuMAP2_00231 HuMAP2_03216 HuMAP2_04786 HuMAP2_06032
OCIAD1	HuMAP2_00029 HuMAP2_03216 HuMAP2_06032
TRO	HuMAP2_03216 HuMAP2_06032
MAGED2	HuMAP2_00029 HuMAP2_00231 HuMAP2_01968 HuMAP2_03216 HuMAP2_04904
GNG10	HuMAP2_03216 HuMAP2_05902
RIC8B	HuMAP2_03216
GNA12	HuMAP2_03216 HuMAP2_06032 HuMAP2_06727
GNB2	HuMAP2_02735 HuMAP2_02804 HuMAP2_03216 HuMAP2_03750 HuMAP2_05976
GNAL	HuMAP2_00029 HuMAP2_00231 HuMAP2_03216 HuMAP2_04786 HuMAP2_06032

hu.MAP 2.0: Complex View

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Complex: HuMAP2_03216