hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03219
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ZNF106 | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | UniProt NCBI |
| KLHL40 | Kelch-like protein 40 (Kelch repeat and BTB domain-containing protein 5) (Sarcosynapsin) | UniProt NCBI |
| KLHL41 | Kelch-like protein 41 (Kel-like protein 23) (Kelch repeat and BTB domain-containing protein 10) (Kelch-related protein 1) (Sarcosin) | UniProt NCBI |
| DUSP11 | RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Dual specificity protein phosphatase 11) (Phosphatase that interacts with RNA/RNP complex 1) | UniProt NCBI |
| CEP85L | Centrosomal protein of 85 kDa-like (Serologically defined breast cancer antigen NY-BR-15) | UniProt NCBI |
| ZNF81 | Zinc finger protein 81 (HFZ20) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0007514 | 0.00270155144475 | 0.333333333333 | KLHL40 KLHL41 | Edema of the dorsum of hands |
| HP:0005855 | 0.00682280818411 | 0.333333333333 | KLHL40 KLHL41 | Multiple prenatal fractures |
| HP:0003798 | 0.00682280818411 | 0.333333333333 | KLHL40 KLHL41 | Nemaline bodies |
| HP:0001623 | 0.0114630974264 | 0.333333333333 | KLHL40 KLHL41 | Breech presentation |
| HP:0010827 | 0.0166795319196 | 0.5 | KLHL40 ZNF81 KLHL41 | Abnormality of the seventh cranial nerve |
| HP:0010628 | 0.0166795319196 | 0.5 | KLHL40 ZNF81 KLHL41 | Facial palsy |
| HP:0001989 | 0.0172946302375 | 0.333333333333 | KLHL40 KLHL41 | Fetal akinesia sequence |
| HP:0100303 | 0.0189383441407 | 0.333333333333 | KLHL40 KLHL41 | Muscle fiber cytoplasmatic inclusion bodies |
| HP:0003327 | 0.0189383441407 | 0.333333333333 | KLHL40 KLHL41 | Axial muscle weakness |
| HP:0030319 | 0.0190936211778 | 0.5 | KLHL40 ZNF81 KLHL41 | Weakness of facial musculature |
| HP:0009025 | 0.0206563100896 | 0.333333333333 | KLHL40 KLHL41 | Increased connective tissue |
| HP:0100299 | 0.0262553193116 | 0.333333333333 | KLHL40 KLHL41 | Muscle fiber inclusion bodies |
| HP:0001291 | 0.0301819152531 | 0.5 | KLHL40 ZNF81 KLHL41 | Abnormal cranial nerve morphology |
| HP:0002375 | 0.0370683023611 | 0.333333333333 | KLHL40 KLHL41 | Hypokinesia |
| HP:0000883 | 0.0370683023611 | 0.333333333333 | KLHL40 KLHL41 | Thin ribs |
| HP:0000301 | 0.0416052534699 | 0.5 | KLHL40 ZNF81 KLHL41 | Abnormality of facial musculature |
| HP:0006824 | 0.0437488392403 | 0.5 | KLHL40 ZNF81 KLHL41 | Cranial nerve paralysis |
| HP:0031910 | 0.0437488392403 | 0.5 | KLHL40 ZNF81 KLHL41 | Abnormal cranial nerve physiology |
| HP:0001349 | 0.044443111782 | 0.333333333333 | KLHL40 KLHL41 | Facial diplegia |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| KLHL40 | CEP85L | 0.639 | 0.686 | bioplex (KLHL40) bioplex_WMM |
| ZNF81 | KLHL40 | 0.594 | 0.666 | bioplex (KLHL40) bioplex_WMM |
| KLHL41 | KLHL40 | 0.16 | 0.417 | bioplex (KLHL40) bioplex_WMM |
| DUSP11 | KLHL40 | 0.151 | 0.411 | bioplex (KLHL40) bioplex_WMM |
| KLHL40 | ZNF106 | 0.024 | 0.214 | bioplex (KLHL40) bioplex_WMM |
| ZNF81 | CEP85L | 0.008 | 0.087 | bioplex_WMM WMM_only |
| KLHL41 | ZNF81 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| ZNF81 | ZNF106 | 0.008 | 0.066 | bioplex_WMM WMM_only |
| KLHL41 | CEP85L | 0.008 | 0.06 | bioplex_WMM WMM_only |
| ZNF81 | DUSP11 | 0.008 | 0.026 | bioplex_WMM WMM_only |
| CEP85L | ZNF106 | 0.008 | 0.024 | bioplex_WMM WMM_only |
| KLHL41 | ZNF106 | 0.008 | 0.024 | bioplex_WMM WMM_only |
| DUSP11 | ZNF106 | 0.008 | 0.025 | bioplex_WMM WMM_only |
| KLHL41 | DUSP11 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| DUSP11 | CEP85L | 0.007 | 0.008 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03219 has an average edge precision of 0.187 which is ranked 6343 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ZNF106 | HuMAP2_02120 HuMAP2_03219 HuMAP2_03313 HuMAP2_03961 HuMAP2_05299 |
| KLHL40 | HuMAP2_00674 HuMAP2_03219 HuMAP2_05299 HuMAP2_06048 |
| KLHL41 | HuMAP2_00258 HuMAP2_00674 HuMAP2_03219 HuMAP2_05299 |
| DUSP11 | HuMAP2_00674 HuMAP2_01087 HuMAP2_02342 HuMAP2_02606 HuMAP2_03219 HuMAP2_07016 |
| CEP85L | HuMAP2_00674 HuMAP2_03219 HuMAP2_05299 HuMAP2_06048 HuMAP2_06680 |
| ZNF81 | HuMAP2_00674 HuMAP2_03219 HuMAP2_05299 HuMAP2_06048 |