hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03224
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| LMO1 | Rhombotin-1 (Cysteine-rich protein TTG-1) (LIM domain only protein 1) (LMO-1) (T-cell translocation protein 1) | UniProt NCBI |
| SSBP3 | Single-stranded DNA-binding protein 3 (Sequence-specific single-stranded-DNA-binding protein) | UniProt NCBI |
| LHX1 | LIM/homeobox protein Lhx1 (LIM homeobox protein 1) (Homeobox protein Lim-1) (hLim-1) | UniProt NCBI |
| LHX6 | LIM/homeobox protein Lhx6 (LIM homeobox protein 6) (LIM/homeobox protein Lhx6.1) | UniProt NCBI |
| LHX2 | LIM/homeobox protein Lhx2 (Homeobox protein LH-2) (LIM homeobox protein 2) | UniProt NCBI |
| LDB1 | LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor) | UniProt NCBI |
| SSBP2 | Single-stranded DNA-binding protein 2 (Sequence-specific single-stranded-DNA-binding protein 2) | UniProt NCBI |
| NUDT22 | Uridine diphosphate glucose pyrophosphatase (UDPG pyrophosphatase) (UGPPase) (EC 3.6.1.45) (Nucleoside diphosphate-linked moiety X motif 22) (Nudix motif 22) | UniProt NCBI |
| LMX1B | LIM homeobox transcription factor 1-beta (LIM/homeobox protein 1.2) (LMX-1.2) (LIM/homeobox protein LMX1B) | UniProt NCBI |
| LMO4 | LIM domain transcription factor LMO4 (Breast tumor autoantigen) (LIM domain only protein 4) (LMO-4) | UniProt NCBI |
| SSBP4 | Single-stranded DNA-binding protein 4 | UniProt NCBI |
| ISL2 | Insulin gene enhancer protein ISL-2 (Islet-2) | UniProt NCBI |
| IDI2 | Isopentenyl-diphosphate delta-isomerase 2 (EC 5.3.3.2) (Isopentenyl pyrophosphate isomerase 2) (IPP isomerase 2) (IPPI2) | UniProt NCBI |
| ISL1 | Insulin gene enhancer protein ISL-1 (Islet-1) | UniProt NCBI |
| LHX8 | LIM/homeobox protein Lhx8 (LIM homeobox protein 8) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0045944 | 4.39232610612e-07 | 0.733333333333 | LHX8 LHX6 SSBP3 SSBP2 LDB1 SSBP4 LHX2 LMX1B LHX1 ISL1 LMO1 | positive regulation of transcription by RNA polymerase II |
| GO:0045893 | 1.30711016104e-05 | 0.733333333333 | LHX8 LHX6 SSBP3 SSBP2 LDB1 SSBP4 LHX2 LMX1B LHX1 ISL1 LMO1 | positive regulation of transcription, DNA-templated |
| GO:1903508 | 1.34712375728e-05 | 0.733333333333 | LHX8 LHX6 SSBP3 SSBP2 LDB1 SSBP4 LHX2 LMX1B LHX1 ISL1 LMO1 | positive regulation of nucleic acid-templated transcription |
| GO:1902680 | 1.36070567105e-05 | 0.733333333333 | LHX8 LHX6 SSBP3 SSBP2 LDB1 SSBP4 LHX2 LMX1B LHX1 ISL1 LMO1 | positive regulation of RNA biosynthetic process |
| GO:0006366 | 2.61616355612e-05 | 0.8 | LHX8 LHX6 SSBP3 SSBP2 LDB1 SSBP4 LMO4 LHX2 LMX1B LHX1 ISL1 LMO1 | transcription by RNA polymerase II |
| GO:0051254 | 2.65871089106e-05 | 0.733333333333 | LHX8 LHX6 SSBP3 SSBP2 LDB1 SSBP4 LHX2 LMX1B LHX1 ISL1 LMO1 | positive regulation of RNA metabolic process |
| GO:0010557 | 7.75824581752e-05 | 0.733333333333 | LHX8 LHX6 SSBP3 SSBP2 LDB1 SSBP4 LHX2 LMX1B LHX1 ISL1 LMO1 | positive regulation of macromolecule biosynthetic process |
| GO:0045935 | 8.23118145661e-05 | 0.733333333333 | LHX8 LHX6 SSBP3 SSBP2 LDB1 SSBP4 LHX2 LMX1B LHX1 ISL1 LMO1 | positive regulation of nucleobase-containing compound metabolic process |
| GO:0031328 | 0.000121419876355 | 0.733333333333 | LHX8 LHX6 SSBP3 SSBP2 LDB1 SSBP4 LHX2 LMX1B LHX1 ISL1 LMO1 | positive regulation of cellular biosynthetic process |
| GO:0009891 | 0.000139257121225 | 0.733333333333 | LHX8 LHX6 SSBP3 SSBP2 LDB1 SSBP4 LHX2 LMX1B LHX1 ISL1 LMO1 | positive regulation of biosynthetic process |
| GO:0010628 | 0.000204681732002 | 0.733333333333 | LHX8 LHX6 SSBP3 SSBP2 LDB1 SSBP4 LHX2 LMX1B LHX1 ISL1 LMO1 | positive regulation of gene expression |
| GO:0006357 | 0.000219345595649 | 0.733333333333 | LHX8 LHX6 SSBP3 SSBP2 LDB1 SSBP4 LHX2 LMX1B LHX1 ISL1 LMO1 | regulation of transcription by RNA polymerase II |
| CORUM:2214 | 0.000280879474705 | 0.133333333333 | LDB1 LMO4 | LMO4-BRCA1-CTIP-LDB1 complex |
| GO:1901362 | 0.00118321314967 | 0.866666666667 | IDI2 LHX6 SSBP3 SSBP2 LHX8 LDB1 SSBP4 LMO4 LHX2 LMX1B LHX1 ISL1 LMO1 | organic cyclic compound biosynthetic process |
| GO:0006351 | 0.00224104394028 | 0.8 | LHX8 LHX6 SSBP3 SSBP2 LDB1 SSBP4 LMO4 LHX2 LMX1B LHX1 ISL1 LMO1 | transcription, DNA-templated |
| GO:0097659 | 0.00231028533292 | 0.8 | LHX8 LHX6 SSBP3 SSBP2 LDB1 SSBP4 LMO4 LHX2 LMX1B LHX1 ISL1 LMO1 | nucleic acid-templated transcription |
| GO:0032774 | 0.00238146553612 | 0.8 | LHX8 LHX6 SSBP3 SSBP2 LDB1 SSBP4 LMO4 LHX2 LMX1B LHX1 ISL1 LMO1 | RNA biosynthetic process |
| GO:0031325 | 0.00276818934146 | 0.8 | LHX8 LHX6 SSBP3 SSBP2 LDB1 SSBP4 LMO4 LHX2 LMX1B LHX1 ISL1 LMO1 | positive regulation of cellular metabolic process |
| WP:WP2064 | 0.00384438525026 | 0.2 | LHX2 ISL1 LHX1 | Neural Crest Differentiation |
| GO:0009893 | 0.00815521500417 | 0.8 | LHX8 LHX6 SSBP3 SSBP2 LDB1 SSBP4 LMO4 LHX2 LMX1B LHX1 ISL1 LMO1 | positive regulation of metabolic process |
| GO:0030182 | 0.00897444821543 | 0.533333333333 | LHX8 LHX6 ISL2 LDB1 ISL1 LMX1B LHX1 LHX2 | neuron differentiation |
| GO:0000790 | 0.0104630448892 | 0.533333333333 | LHX8 LHX6 ISL2 LDB1 ISL1 LMX1B LHX1 LHX2 | nuclear chromatin |
| GO:0034654 | 0.0119386557546 | 0.8 | LHX8 LHX6 SSBP3 SSBP2 LDB1 SSBP4 LMO4 LHX2 LMX1B LHX1 ISL1 LMO1 | nucleobase-containing compound biosynthetic process |
| GO:0018130 | 0.0146843508603 | 0.8 | LHX8 LHX6 SSBP3 SSBP2 LDB1 SSBP4 LMO4 LHX2 LMX1B LHX1 ISL1 LMO1 | heterocycle biosynthetic process |
| GO:0019438 | 0.0147471930899 | 0.8 | LHX8 LHX6 SSBP3 SSBP2 LDB1 SSBP4 LMO4 LHX2 LMX1B LHX1 ISL1 LMO1 | aromatic compound biosynthetic process |
| GO:0006355 | 0.0164405903238 | 0.733333333333 | LHX8 LHX6 SSBP3 SSBP2 LDB1 SSBP4 LHX2 LMX1B LHX1 ISL1 LMO1 | regulation of transcription, DNA-templated |
| GO:1903506 | 0.0169386298131 | 0.733333333333 | LHX8 LHX6 SSBP3 SSBP2 LDB1 SSBP4 LHX2 LMX1B LHX1 ISL1 LMO1 | regulation of nucleic acid-templated transcription |
| GO:2001141 | 0.0171926928389 | 0.733333333333 | LHX8 LHX6 SSBP3 SSBP2 LDB1 SSBP4 LHX2 LMX1B LHX1 ISL1 LMO1 | regulation of RNA biosynthetic process |
| GO:0048699 | 0.020391456226 | 0.533333333333 | LHX8 LHX6 ISL2 LDB1 ISL1 LMX1B LHX1 LHX2 | generation of neurons |
| GO:0051173 | 0.0276250427243 | 0.733333333333 | LHX8 LHX6 SSBP3 SSBP2 LDB1 SSBP4 LHX2 LMX1B LHX1 ISL1 LMO1 | positive regulation of nitrogen compound metabolic process |
| GO:0021953 | 0.0277015394675 | 0.266666666667 | LHX8 LHX6 ISL1 LHX1 | central nervous system neuron differentiation |
| GO:0022008 | 0.0297625117388 | 0.533333333333 | LHX8 LHX6 ISL2 LDB1 ISL1 LMX1B LHX1 LHX2 | neurogenesis |
| GO:0140110 | 0.0340113736612 | 0.6 | LHX8 LHX6 LMO4 ISL2 LDB1 ISL1 LMX1B LHX1 LHX2 | transcription regulator activity |
| GO:0007399 | 0.0368743383165 | 0.6 | LHX8 LHX6 LMO4 ISL2 LDB1 ISL1 LMX1B LHX1 LHX2 | nervous system development |
| GO:0000785 | 0.037255906565 | 0.533333333333 | LHX8 LHX6 ISL2 LDB1 ISL1 LMX1B LHX1 LHX2 | chromatin |
| GO:0003700 | 0.0470906836301 | 0.533333333333 | LHX8 LHX6 LMO4 ISL2 ISL1 LMX1B LHX1 LHX2 | DNA-binding transcription factor activity |
| GO:0044454 | 0.0478714919337 | 0.533333333333 | LHX8 LHX6 ISL2 LDB1 ISL1 LMX1B LHX1 LHX2 | nuclear chromosome part |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LDB1 | SSBP4 | 1.0 | 0.949 | bioplex (SSBP4) bioplex_WMM |
| LDB1 | SSBP3 | 1.0 | 0.949 | bioplex (SSBP3) bioplex_WMM |
| LMO4 | SSBP4 | 0.998 | 0.937 | bioplex (SSBP4) bioplex_WMM |
| LDB1 | SSBP2 | 0.994 | 0.923 | bioplex (SSBP2) bioplex_WMM |
| SSBP3 | SSBP4 | 0.993 | 0.918 | bioplex (SSBP3,SSBP4) bioplex_WMM |
| SSBP4 | ISL1 | 0.99 | 0.909 | bioplex (SSBP4) bioplex_WMM |
| SSBP4 | ISL2 | 0.987 | 0.901 | bioplex (SSBP4) bioplex_WMM |
| SSBP2 | SSBP4 | 0.984 | 0.899 | bioplex (SSBP2,SSBP4) bioplex_WMM |
| SSBP3 | SSBP2 | 0.982 | 0.897 | bioplex (SSBP2,SSBP3) bioplex_WMM |
| LHX6 | LDB1 | 0.967 | 0.879 | bioplex (LHX6) bioplex_WMM |
| SSBP3 | ISL2 | 0.94 | 0.852 | bioplex (SSBP3) bioplex_WMM |
| SSBP2 | ISL2 | 0.918 | 0.841 | bioplex (SSBP2) bioplex_WMM |
| SSBP2 | ISL1 | 0.789 | 0.758 | bioplex (SSBP2) bioplex_WMM |
| SSBP3 | LHX2 | 0.782 | 0.755 | bioplex (SSBP3) bioplex_WMM |
| SSBP3 | LMO4 | 0.729 | 0.735 | bioplex (SSBP3) bioplex_WMM |
| SSBP3 | ISL1 | 0.691 | 0.715 | bioplex (SSBP3) bioplex_WMM |
| LHX6 | SSBP3 | 0.521 | 0.633 | bioplex (LHX6) bioplex_WMM |
| LMO1 | SSBP4 | 0.474 | 0.609 | bioplex (SSBP4) bioplex_WMM |
| SSBP2 | LMO4 | 0.428 | 0.576 | bioplex (SSBP2) bioplex_WMM |
| LMO4 | IDI2 | 0.425 | 0.575 | bioplex (IDI2) bioplex_WMM |
| SSBP3 | IDI2 | 0.422 | 0.573 | bioplex (IDI2) bioplex_WMM |
| LMX1B | SSBP4 | 0.373 | 0.546 | bioplex (LMX1B,SSBP4) bioplex_WMM |
| LMX1B | SSBP2 | 0.307 | 0.502 | bioplex (LMX1B,SSBP2) bioplex_WMM |
| SSBP3 | LMX1B | 0.301 | 0.496 | bioplex (LMX1B,SSBP3) bioplex_WMM |
| LHX6 | SSBP4 | 0.289 | 0.49 | bioplex (LHX6) bioplex_WMM |
| LHX1 | SSBP4 | 0.266 | 0.482 | bioplex (SSBP4) bioplex_WMM |
| LDB1 | LMX1B | 0.242 | 0.468 | bioplex (LMX1B) bioplex_WMM |
| SSBP2 | IDI2 | 0.227 | 0.468 | bioplex (IDI2) bioplex_WMM |
| SSBP4 | LHX8 | 0.196 | 0.449 | bioplex (SSBP4) bioplex_WMM |
| LDB1 | IDI2 | 0.19 | 0.442 | bioplex (IDI2) bioplex_WMM |
| LHX6 | SSBP2 | 0.146 | 0.409 | bioplex (LHX6) bioplex_WMM |
| LHX6 | NUDT22 | 0.09 | 0.355 | bioplex (LHX6) bioplex_WMM |
| SSBP4 | IDI2 | 0.052 | 0.303 | bioplex (IDI2) bioplex_WMM |
| SSBP3 | LHX1 | 0.031 | 0.238 | bioplex (SSBP3) bioplex_WMM |
| ISL2 | ISL1 | 0.021 | 0.191 | bioplex_WMM WMM_only |
| LMX1B | LMO4 | 0.017 | 0.175 | bioplex_WMM WMM_only |
| LDB1 | ISL2 | 0.016 | 0.161 | bioplex_WMM WMM_only |
| LDB1 | LMO4 | 0.015 | 0.14 | bioplex_WMM WMM_only |
| LMO4 | ISL2 | 0.014 | 0.143 | bioplex_WMM WMM_only |
| LDB1 | ISL1 | 0.014 | 0.143 | bioplex_WMM WMM_only |
| LMO4 | ISL1 | 0.013 | 0.151 | bioplex_WMM WMM_only |
| LMX1B | ISL2 | 0.012 | 0.145 | bioplex_WMM WMM_only |
| LMX1B | ISL1 | 0.012 | 0.149 | bioplex_WMM WMM_only |
| LHX1 | LMO4 | 0.011 | 0.144 | bioplex_WMM WMM_only |
| LHX1 | ISL1 | 0.011 | 0.141 | bioplex_WMM WMM_only |
| LHX1 | ISL2 | 0.011 | 0.141 | bioplex_WMM WMM_only |
| LMX1B | LHX1 | 0.011 | 0.142 | bioplex_WMM WMM_only |
| SSBP2 | LHX1 | 0.01 | 0.13 | bioplex_WMM WMM_only |
| LDB1 | LHX1 | 0.01 | 0.112 | bioplex_WMM WMM_only |
| LHX1 | LHX8 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| LMO1 | LHX8 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| LMO4 | LHX8 | 0.009 | 0.096 | bioplex_WMM WMM_only |
| ISL1 | LHX8 | 0.009 | 0.098 | bioplex_WMM WMM_only |
| ISL2 | LHX8 | 0.009 | 0.093 | bioplex_WMM WMM_only |
| LMX1B | LHX8 | 0.009 | 0.092 | bioplex_WMM WMM_only |
| LHX2 | LHX1 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| LMO1 | LHX1 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| SSBP2 | LHX8 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| NUDT22 | SSBP2 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| SSBP3 | LHX8 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| SSBP3 | NUDT22 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| NUDT22 | SSBP4 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| LDB1 | NUDT22 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| LDB1 | LHX8 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| LHX2 | LMO4 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| LMO1 | LMO4 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| LHX2 | ISL1 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| LMO1 | ISL1 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| LMO1 | ISL2 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| LHX2 | ISL2 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| LHX2 | LMX1B | 0.008 | 0.067 | bioplex_WMM WMM_only |
| LMX1B | LMO1 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| LMO1 | SSBP2 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| LHX2 | SSBP2 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| SSBP3 | LMO1 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| LHX2 | SSBP4 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| LDB1 | LMO1 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| LDB1 | LHX2 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| LMX1B | IDI2 | 0.003 | 0.015 | bioplex (IDI2) bioplex_WMM |
| ISL2 | IDI2 | 0.0 | 0.001 | bioplex (IDI2) bioplex_WMM |
Images
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Complex HuMAP2_03224 has an average edge precision of 0.337 which is ranked 4157 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| LMO1 | HuMAP2_03224 |
| SSBP3 | HuMAP2_01977 HuMAP2_03224 |
| LHX1 | HuMAP2_03224 |
| LHX6 | HuMAP2_01442 HuMAP2_03054 HuMAP2_03224 HuMAP2_04214 |
| LHX2 | HuMAP2_01977 HuMAP2_03224 |
| LDB1 | HuMAP2_01442 HuMAP2_03224 HuMAP2_06968 |
| SSBP2 | HuMAP2_03224 HuMAP2_06968 |
| NUDT22 | HuMAP2_03054 HuMAP2_03224 |
| LMX1B | HuMAP2_03224 HuMAP2_03320 HuMAP2_03752 HuMAP2_05451 |
| LMO4 | HuMAP2_03224 HuMAP2_06968 |
| SSBP4 | HuMAP2_03224 HuMAP2_06968 |
| ISL2 | HuMAP2_03224 HuMAP2_06968 |
| IDI2 | HuMAP2_03224 |
| ISL1 | HuMAP2_03224 HuMAP2_06968 |
| LHX8 | HuMAP2_03224 |