hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03226
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SH3RF1 | E3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2) | UniProt NCBI |
| TRIM25 | E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147) | UniProt NCBI |
| EIF4E | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) | UniProt NCBI |
| ANGEL1 | Protein angel homolog 1 | UniProt NCBI |
| EIF4EBP2 | Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) | UniProt NCBI |
| EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) | UniProt NCBI |
| TTC5 | Tetratricopeptide repeat protein 5 (TPR repeat protein 5) (Stress-responsive activator of p300) (Strap) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0031369 | 9.04373637949e-06 | 0.571428571429 | EIF4EBP2 ANGEL1 EIF4EBP1 EIF4E | translation initiation factor binding |
| GO:0008190 | 6.35345863999e-05 | 0.428571428571 | EIF4EBP2 EIF4EBP1 ANGEL1 | eukaryotic initiation factor 4E binding |
| WP:WP107 | 6.56529842161e-05 | 0.428571428571 | EIF4EBP2 EIF4EBP1 EIF4E | Translation Factors |
| WP:WP3879 | 0.00153544244266 | 0.285714285714 | EIF4E EIF4EBP1 | 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression |
| WP:WP516 | 0.00153544244266 | 0.285714285714 | EIF4E EIF4EBP1 | Hypertrophy Model |
| KEGG:03013 | 0.0018918646369 | 0.428571428571 | EIF4EBP2 EIF4EBP1 EIF4E | RNA transport |
| REAC:R-HSA-166208 | 0.00728151453382 | 0.285714285714 | EIF4E EIF4EBP1 | mTORC1-mediated signalling |
| WP:WP4566 | 0.0103218724353 | 0.285714285714 | EIF4E EIF4EBP1 | Translation inhibitors in chronically activated PDGFRA cells |
| WP:WP585 | 0.0142455486943 | 0.285714285714 | EIF4E EIF4EBP1 | Interferon type I signaling pathways |
| REAC:R-HSA-165159 | 0.023268809464 | 0.285714285714 | EIF4E EIF4EBP1 | mTOR signalling |
| KEGG:01521 | 0.0263752467347 | 0.285714285714 | EIF4E EIF4EBP1 | EGFR tyrosine kinase inhibitor resistance |
| WP:WP2034 | 0.0267680695584 | 0.285714285714 | EIF4E EIF4EBP1 | Leptin signaling pathway |
| KEGG:04211 | 0.0323714198719 | 0.285714285714 | EIF4E EIF4EBP1 | Longevity regulating pathway |
| KEGG:04066 | 0.048055671732 | 0.285714285714 | EIF4E EIF4EBP1 | HIF-1 signaling pathway |
| CORUM:2717 | 0.0499886427319 | 0.142857142857 | TRIM25 | Ubiquitin E3 ligase (TRIM25, DDX58) |
| CORUM:3138 | 0.0499886427319 | 0.142857142857 | SH3RF1 | POSH-AKT2 complex |
| CORUM:7357 | 0.0499886427319 | 0.142857142857 | TRIM25 | TRIM25-G3BP2 complex |
| CORUM:1299 | 0.0499886427319 | 0.142857142857 | SH3RF1 | POSH-MLK3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EIF4E | EIF4EBP1 | 0.978 | 0.893 | bioplex (EIF4E) bioplex_WMM fraction |
| EIF4E | EIF4EBP2 | 0.716 | 0.729 | bioplex (EIF4E) bioplex_WMM fraction |
| ANGEL1 | EIF4E | 0.595 | 0.665 | bioplex (EIF4E) bioplex_WMM |
| EIF4EBP2 | EIF4EBP1 | 0.103 | 0.366 | bioplex_WMM fraction |
| EIF4E | TRIM25 | 0.102 | 0.366 | youn (TRIM25) youn_WMM fraction |
| TRIM25 | TTC5 | 0.073 | 0.354 | fraction |
| EIF4E | SH3RF1 | 0.021 | 0.185 | youn_WMM fraction |
| EIF4EBP2 | TRIM25 | 0.01 | 0.103 | gupta_WMM fraction |
| ANGEL1 | EIF4EBP2 | 0.008 | 0.024 | bioplex_WMM WMM_only |
| ANGEL1 | EIF4EBP1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| EIF4EBP1 | TRIM25 | 0.007 | 0.002 | gupta_WMM WMM_only |
| ANGEL1 | TTC5 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| TRIM25 | SH3RF1 | 0.006 | 0.006 | youn (TRIM25) youn_WMM gupta_WMM |
| EIF4E | TTC5 | 0.0 | 0.001 | bioplex (TTC5) bioplex_WMM fraction |
Images
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Complex HuMAP2_03226 has an average edge precision of 0.264 which is ranked 5142 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SH3RF1 | HuMAP2_03226 |
| TRIM25 | HuMAP2_02607 HuMAP2_03226 HuMAP2_04561 |
| EIF4E | HuMAP2_00638 HuMAP2_03226 HuMAP2_04754 HuMAP2_05719 |
| ANGEL1 | HuMAP2_00135 HuMAP2_01287 HuMAP2_03226 HuMAP2_04754 HuMAP2_05719 HuMAP2_06115 |
| EIF4EBP2 | HuMAP2_00638 HuMAP2_02769 HuMAP2_03226 HuMAP2_04754 HuMAP2_05137 HuMAP2_05719 |
| EIF4EBP1 | HuMAP2_00638 HuMAP2_02769 HuMAP2_03226 HuMAP2_04754 HuMAP2_05719 |
| TTC5 | HuMAP2_02607 HuMAP2_03226 HuMAP2_04561 |