hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03232
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SDHAF2 | Succinate dehydrogenase assembly factor 2, mitochondrial (SDH assembly factor 2) (SDHAF2) | UniProt NCBI |
| PDZRN3 | E3 ubiquitin-protein ligase PDZRN3 (EC 2.3.2.27) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (RING-type E3 ubiquitin transferase PDZRN3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3) | UniProt NCBI |
| ERP44 | Endoplasmic reticulum resident protein 44 (ER protein 44) (ERp44) (Thioredoxin domain-containing protein 4) | UniProt NCBI |
| SDHA | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II) (Fp) | UniProt NCBI |
| SDHB | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC 1.3.5.1) (Iron-sulfur subunit of complex II) (Ip) | UniProt NCBI |
| ELAVL1 | ELAV-like protein 1 (Hu-antigen R) (HuR) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0006737 | 3.32599070026e-06 | 0.5 | SDHB SDHAF2 SDHA | Extraadrenal pheochromocytoma |
| HP:0008629 | 3.32599070026e-06 | 0.5 | SDHB SDHAF2 SDHA | Pulsatile tinnitus |
| HP:0000740 | 3.32599070026e-06 | 0.5 | SDHB SDHAF2 SDHA | Episodic paroxysmal anxiety |
| HP:0010532 | 3.32599070026e-06 | 0.5 | SDHB SDHAF2 SDHA | Paroxysmal vertigo |
| HP:0002864 | 3.32599070026e-06 | 0.5 | SDHB SDHAF2 SDHA | Paraganglioma of head and neck |
| HP:0003639 | 3.32599070026e-06 | 0.5 | SDHB SDHAF2 SDHA | Elevated urinary epinephrine |
| HP:0009711 | 4.43398396567e-06 | 0.5 | SDHB SDHAF2 SDHA | Retinal capillary hemangioma |
| HP:0001095 | 4.43398396567e-06 | 0.5 | SDHB SDHAF2 SDHA | Hypertensive retinopathy |
| HP:0100642 | 4.43398396567e-06 | 0.5 | SDHB SDHAF2 SDHA | Neoplasm of the adrenal medulla |
| HP:0012222 | 4.43398396567e-06 | 0.5 | SDHB SDHAF2 SDHA | Arachnoid hemangiomatosis |
| HP:0006748 | 4.43398396567e-06 | 0.5 | SDHB SDHAF2 SDHA | Adrenal pheochromocytoma |
| HP:0003345 | 4.43398396567e-06 | 0.5 | SDHB SDHAF2 SDHA | Elevated urinary norepinephrine |
| HP:0003574 | 4.43398396567e-06 | 0.5 | SDHB SDHAF2 SDHA | Positive regitine blocking test |
| HP:0011979 | 5.76330785731e-06 | 0.5 | SDHB SDHAF2 SDHA | Elevated urinary dopamine |
| HP:0002331 | 5.76330785731e-06 | 0.5 | SDHB SDHAF2 SDHA | Recurrent paroxysmal headache |
| HP:0002640 | 5.76330785731e-06 | 0.5 | SDHB SDHAF2 SDHA | Hypertension associated with pheochromocytoma |
| HP:0010797 | 7.33401028552e-06 | 0.5 | SDHB SDHAF2 SDHA | Hemangioblastoma |
| HP:0003528 | 7.33401028552e-06 | 0.5 | SDHB SDHAF2 SDHA | Elevated calcitonin |
| HP:0002666 | 9.16612699891e-06 | 0.5 | SDHB SDHAF2 SDHA | Pheochromocytoma |
| HP:0002668 | 9.16612699891e-06 | 0.5 | SDHB SDHAF2 SDHA | Paraganglioma |
| HP:0031284 | 1.36946854865e-05 | 0.5 | SDHB SDHAF2 SDHA | Flushing |
| HP:0001069 | 1.36946854865e-05 | 0.5 | SDHB SDHAF2 SDHA | Episodic hyperhidrosis |
| HP:0009594 | 1.36946854865e-05 | 0.5 | SDHB SDHAF2 SDHA | Retinal hamartoma |
| HP:0011703 | 1.64311379786e-05 | 0.5 | SDHB SDHAF2 SDHA | Sinus tachycardia |
| HP:0011976 | 2.2948325134e-05 | 0.5 | SDHB SDHAF2 SDHA | Elevated urinary catecholamines |
| HP:0011281 | 2.2948325134e-05 | 0.5 | SDHB SDHAF2 SDHA | Abnormality of urine catecholamine concentration |
| HP:0001293 | 3.09909944032e-05 | 0.5 | SDHB SDHAF2 SDHA | Cranial nerve compression |
| HP:0010568 | 3.09909944032e-05 | 0.5 | SDHB SDHAF2 SDHA | Hamartoma of the eye |
| HP:0030670 | 3.09909944032e-05 | 0.5 | SDHB SDHAF2 SDHA | Hamartoma of the orbital region |
| HP:0100634 | 5.88182677893e-05 | 0.5 | SDHB SDHAF2 SDHA | Neuroendocrine neoplasm |
| HP:0025269 | 5.88182677893e-05 | 0.5 | SDHB SDHAF2 SDHA | Panic attack |
| HP:0002574 | 6.58664956884e-05 | 0.5 | SDHB SDHAF2 SDHA | Episodic abdominal pain |
| HP:0031801 | 6.58664956884e-05 | 0.5 | SDHB SDHAF2 SDHA | Vocal cord dysfunction |
| HP:0032148 | 6.58664956884e-05 | 0.5 | SDHB SDHAF2 SDHA | Episodic pain |
| HP:0001605 | 6.58664956884e-05 | 0.5 | SDHB SDHAF2 SDHA | Vocal cord paralysis |
| HP:0100631 | 7.34553632007e-05 | 0.5 | SDHB SDHAF2 SDHA | Neoplasm of the adrenal gland |
| HP:0100530 | 8.1604724041e-05 | 0.5 | SDHB SDHAF2 SDHA | Abnormal calcium-phosphate regulating hormone level |
| HP:0000526 | 0.000120203751216 | 0.5 | SDHB SDHAF2 SDHA | Aniridia |
| HP:0000360 | 0.000120203751216 | 0.5 | SDHB SDHAF2 SDHA | Tinnitus |
| HP:0100012 | 0.000143381531621 | 0.5 | SDHB SDHAF2 SDHA | Neoplasm of the eye |
| HP:0003072 | 0.000213906300353 | 0.5 | SDHB SDHAF2 SDHA | Hypercalcemia |
| HP:0100007 | 0.000213906300353 | 0.5 | SDHB SDHAF2 SDHA | Neoplasm of the peripheral nervous system |
| HP:0003001 | 0.000225371341878 | 0.333333333333 | SDHAF2 SDHB | Glomus jugular tumor |
| HP:0030074 | 0.000225371341878 | 0.333333333333 | SDHAF2 SDHB | Chemodectoma |
| HP:0001342 | 0.000230325766317 | 0.5 | SDHB SDHAF2 SDHA | Cerebral hemorrhage |
| HP:0011702 | 0.000304375323156 | 0.5 | SDHB SDHAF2 SDHA | Abnormal electrophysiology of sinoatrial node origin |
| HP:0002018 | 0.000325078967548 | 0.5 | SDHB SDHAF2 SDHA | Nausea |
| HP:0005584 | 0.000417247653264 | 0.5 | SDHB SDHAF2 SDHA | Renal cell carcinoma |
| HP:0000096 | 0.000417247653264 | 0.5 | SDHB SDHAF2 SDHA | Glomerulosclerosis |
| HP:0025191 | 0.00045066196833 | 0.333333333333 | SDHA SDHB | Segmental myoclonic seizures |
| HP:0001962 | 0.000554974810191 | 0.5 | SDHB SDHAF2 SDHA | Palpitations |
| HP:0040196 | 0.000750968775169 | 0.333333333333 | SDHA SDHB | Mild microcephaly |
| WP:WP78 | 0.000758026533465 | 0.333333333333 | SDHA SDHB | TCA Cycle (aka Krebs or citric acid cycle) |
| HP:0010566 | 0.00079420087652 | 0.5 | SDHB SDHAF2 SDHA | Hamartoma |
| HP:0100749 | 0.000833133701725 | 0.5 | SDHB SDHAF2 SDHA | Chest pain |
| HP:0011732 | 0.00104690256006 | 0.5 | SDHB SDHAF2 SDHA | Abnormality of adrenal morphology |
| HP:0003756 | 0.00112625143517 | 0.333333333333 | SDHA SDHB | Skeletal myopathy |
| HP:0012817 | 0.00112625143517 | 0.333333333333 | SDHA SDHB | Noncompaction cardiomyopathy |
| HP:0100835 | 0.00114168764513 | 0.5 | SDHB SDHAF2 SDHA | Benign neoplasm of the central nervous system |
| HP:0001618 | 0.00119114569589 | 0.5 | SDHB SDHAF2 SDHA | Dysphonia |
| HP:0002321 | 0.00183201380014 | 0.5 | SDHB SDHAF2 SDHA | Vertigo |
| HP:0007083 | 0.00210158306671 | 0.333333333333 | SDHA SDHB | Hyperactive patellar reflex |
| HP:0002170 | 0.00218636590141 | 0.5 | SDHB SDHAF2 SDHA | Intracranial hemorrhage |
| HP:0009726 | 0.00218636590141 | 0.5 | SDHB SDHAF2 SDHA | Renal neoplasm |
| HP:0004363 | 0.00241935032153 | 0.5 | SDHB SDHAF2 SDHA | Abnormal circulating calcium concentration |
| KEGG:00020 | 0.0025298764655 | 0.333333333333 | SDHA SDHB | Citrate cycle (TCA cycle) |
| HP:0100568 | 0.00266824580105 | 0.5 | SDHB SDHAF2 SDHA | Neoplasm of the endocrine system |
| HP:0007272 | 0.00270155144475 | 0.333333333333 | SDHA SDHB | Progressive psychomotor deterioration |
| HP:0008055 | 0.0028432701083 | 0.5 | SDHB SDHAF2 SDHA | Aplasia/Hypoplasia affecting the uvea |
| HP:0008053 | 0.0028432701083 | 0.5 | SDHB SDHAF2 SDHA | Aplasia/Hypoplasia of the iris |
| HP:0010927 | 0.0032158301853 | 0.5 | SDHB SDHAF2 SDHA | Abnormal blood inorganic cation concentration |
| HP:0008062 | 0.0032158301853 | 0.5 | SDHB SDHAF2 SDHA | Aplasia/Hypoplasia affecting the anterior segment of the eye |
| HP:0011166 | 0.00337633448894 | 0.333333333333 | SDHA SDHB | Focal myoclonic seizures |
| HP:0010786 | 0.00361941962178 | 0.5 | SDHB SDHAF2 SDHA | Urinary tract neoplasm |
| HP:0001751 | 0.00372530767778 | 0.5 | SDHB SDHAF2 SDHA | Vestibular dysfunction |
| HP:0001028 | 0.00383322991569 | 0.5 | SDHB SDHAF2 SDHA | Hemangioma |
| HP:0000790 | 0.00383322991569 | 0.5 | SDHB SDHAF2 SDHA | Hematuria |
| HP:0012614 | 0.00383322991569 | 0.5 | SDHB SDHAF2 SDHA | Abnormal urine cytology |
| HP:0003470 | 0.00383322991569 | 0.5 | SDHB SDHAF2 SDHA | Paralysis |
| HP:0100742 | 0.00405525264868 | 0.5 | SDHB SDHAF2 SDHA | Vascular neoplasm |
| HP:0000975 | 0.00405525264868 | 0.5 | SDHB SDHAF2 SDHA | Hyperhidrosis |
| HP:0011343 | 0.00412589193299 | 0.333333333333 | SDHA SDHB | Moderate global developmental delay |
| REAC:R-HSA-71403 | 0.00464022545552 | 0.333333333333 | SDHA SDHB | Citric acid cycle (TCA cycle) |
| HP:0100006 | 0.00464723136975 | 0.5 | SDHB SDHAF2 SDHA | Neoplasm of the central nervous system |
| HP:0007350 | 0.00495018352279 | 0.333333333333 | SDHA SDHB | Hyperreflexia in upper limbs |
| HP:0000980 | 0.00529384191417 | 0.5 | SDHB SDHAF2 SDHA | Pallor |
| HP:0100723 | 0.00584916901642 | 0.333333333333 | SDHA SDHB | Gastrointestinal stroma tumor |
| HP:0002333 | 0.00584916901642 | 0.333333333333 | SDHA SDHB | Motor deterioration |
| HP:0100833 | 0.00584916901642 | 0.333333333333 | SDHA SDHB | Neoplasm of the small intestine |
| HP:0031263 | 0.00629535408062 | 0.5 | SDHB SDHAF2 SDHA | Abnormal renal corpuscle morphology |
| HP:0000095 | 0.00629535408062 | 0.5 | SDHB SDHAF2 SDHA | Abnormality of renal glomerulus morphology |
| GO:0006099 | 0.00734442516369 | 0.5 | SDHB SDHAF2 SDHA | tricarboxylic acid cycle |
| HP:0002474 | 0.00787106080828 | 0.333333333333 | SDHA SDHB | Expressive language delay |
| HP:0006895 | 0.00787106080828 | 0.333333333333 | SDHA SDHB | Lower limb hypertonia |
| HP:0000093 | 0.00811026271504 | 0.5 | SDHB SDHAF2 SDHA | Proteinuria |
| HP:0100751 | 0.00899388668352 | 0.333333333333 | SDHA SDHB | Esophageal neoplasm |
| HP:0004375 | 0.00903835350739 | 0.5 | SDHB SDHAF2 SDHA | Neoplasm of the nervous system |
| HP:0020129 | 0.00962755859765 | 0.5 | SDHB SDHAF2 SDHA | Abnormal urine protein level |
| HP:0011035 | 0.0102416371513 | 0.5 | SDHB SDHAF2 SDHA | Abnormal renal cortex morphology |
| HP:0000834 | 0.0106650876034 | 0.5 | SDHB SDHAF2 SDHA | Abnormality of the adrenal glands |
| HP:0007550 | 0.0110999618929 | 0.5 | SDHB SDHAF2 SDHA | Hypohidrosis or hyperhidrosis |
| HP:0007379 | 0.0110999618929 | 0.5 | SDHB SDHAF2 SDHA | Neoplasm of the genitourinary tract |
| HP:0012288 | 0.0114630974264 | 0.333333333333 | SDHA SDHB | Neoplasm of head and neck |
| HP:0025276 | 0.0124745993467 | 0.5 | SDHB SDHAF2 SDHA | Abnormality of skin adnexa physiology |
| HP:0008046 | 0.0139573410906 | 0.5 | SDHB SDHAF2 SDHA | Abnormal retinal vascular morphology |
| HP:0001635 | 0.014740486186 | 0.5 | SDHB SDHAF2 SDHA | Congestive heart failure |
| HP:0012575 | 0.015552137599 | 0.5 | SDHB SDHAF2 SDHA | Abnormal nephron morphology |
| HP:0010929 | 0.0175596076186 | 0.5 | SDHB SDHAF2 SDHA | Abnormal blood cation concentration |
| GO:0006121 | 0.020283420769 | 0.333333333333 | SDHAF2 SDHA | mitochondrial electron transport, succinate to ubiquinone |
| HP:0006801 | 0.0206563100896 | 0.333333333333 | SDHA SDHB | Hyperactive deep tendon reflexes |
| HP:0011153 | 0.0224484879882 | 0.333333333333 | SDHA SDHB | Focal motor seizure |
| WP:WP111 | 0.0235215924424 | 0.333333333333 | SDHA SDHB | Electron Transport Chain (OXPHOS system in mitochondria) |
| HP:0003111 | 0.0249658824542 | 0.5 | SDHB SDHAF2 SDHA | Abnormal blood ion concentration |
| HP:0002027 | 0.0280983679133 | 0.5 | SDHB SDHAF2 SDHA | Abdominal pain |
| HP:0007700 | 0.0289200021372 | 0.5 | SDHB SDHAF2 SDHA | Ocular anterior segment dysgenesis |
| REAC:R-HSA-71406 | 0.029137346631 | 0.333333333333 | SDHA SDHB | Pyruvate metabolism and Citric Acid (TCA) cycle |
| HP:0001291 | 0.0301819152531 | 0.5 | SDHB SDHAF2 SDHA | Abnormal cranial nerve morphology |
| HP:0006957 | 0.030358517586 | 0.333333333333 | SDHA SDHB | Loss of ability to walk |
| HP:0011029 | 0.0314796075901 | 0.5 | SDHB SDHAF2 SDHA | Internal hemorrhage |
| HP:0100659 | 0.0341842384581 | 0.5 | SDHB SDHAF2 SDHA | Abnormality of the cerebral vasculature |
| HP:0001824 | 0.035118668508 | 0.5 | SDHB SDHAF2 SDHA | Weight loss |
| HP:0011028 | 0.0360697763573 | 0.5 | SDHB SDHAF2 SDHA | Abnormality of blood circulation |
| HP:0000739 | 0.0390245705401 | 0.5 | SDHB SDHAF2 SDHA | Anxiety |
| HP:0100743 | 0.0394527338604 | 0.333333333333 | SDHA SDHB | Neoplasm of the rectum |
| KEGG:01200 | 0.039527830217 | 0.333333333333 | SDHA SDHB | Carbon metabolism |
| GO:0045273 | 0.0405595771497 | 0.333333333333 | SDHA SDHB | respiratory chain complex II |
| GO:0045257 | 0.0405595771497 | 0.333333333333 | SDHA SDHB | succinate dehydrogenase complex (ubiquinone) |
| GO:0005749 | 0.0405595771497 | 0.333333333333 | SDHA SDHB | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) |
| GO:0045283 | 0.0405595771497 | 0.333333333333 | SDHA SDHB | fumarate reductase complex |
| GO:0045281 | 0.0405595771497 | 0.333333333333 | SDHA SDHB | succinate dehydrogenase complex |
| HP:0100852 | 0.0405599116431 | 0.5 | SDHB SDHAF2 SDHA | Abnormal fear/anxiety-related behavior |
| HP:0002315 | 0.0421345110279 | 0.5 | SDHB SDHAF2 SDHA | Headache |
| HP:0011792 | 0.0421345110279 | 0.5 | SDHB SDHAF2 SDHA | Neoplasm by histology |
| KEGG:00190 | 0.0423326508178 | 0.333333333333 | SDHA SDHB | Oxidative phosphorylation |
| KEGG:05012 | 0.0482240719397 | 0.333333333333 | SDHA SDHB | Parkinson disease |
| HP:0001285 | 0.0497285764978 | 0.333333333333 | SDHA SDHB | Spastic tetraparesis |
| HP:0002395 | 0.0497285764978 | 0.333333333333 | SDHA SDHB | Lower limb hyperreflexia |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SDHA | SDHB | 0.999 | 0.949 | bioplex (SDHA,SDHB) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM |
| SDHAF2 | SDHA | 0.983 | 0.899 | hein_WMM bioplex (SDHA) bioplex_WMM hein (SDHAF2) |
| PDZRN3 | SDHA | 0.098 | 0.358 | bioplex (SDHA) bioplex_WMM gupta_WMM boldt_WMM |
| ELAVL1 | SDHB | 0.086 | 0.351 | bioplex (SDHB) bioplex_WMM youn_WMM fraction |
| ERP44 | SDHB | 0.065 | 0.346 | bioplex (ERP44,SDHB) bioplex_WMM fraction |
| ERP44 | SDHA | 0.045 | 0.287 | bioplex (ERP44,SDHA) bioplex_WMM boldt fraction boldt_WMM |
| PDZRN3 | SDHAF2 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| SDHAF2 | SDHB | 0.008 | 0.024 | bioplex_WMM WMM_only |
| PDZRN3 | SDHB | 0.007 | 0.003 | bioplex_WMM WMM_only |
| ELAVL1 | PDZRN3 | 0.007 | 0.001 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ERP44 | PDZRN3 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| ERP44 | SDHAF2 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| ERP44 | ELAVL1 | 0.006 | 0.004 | bioplex_WMM gupta_WMM WMM_only treiber_WMM |
| ELAVL1 | SDHA | 0.003 | 0.017 | bioplex_WMM youn_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_03232 has an average edge precision of 0.236 which is ranked 5591 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SDHAF2 | HuMAP2_03232 HuMAP2_04642 HuMAP2_04832 HuMAP2_05446 |
| PDZRN3 | HuMAP2_01087 HuMAP2_03232 HuMAP2_03997 HuMAP2_04832 HuMAP2_05446 HuMAP2_05666 HuMAP2_07016 |
| ERP44 | HuMAP2_00080 HuMAP2_00194 HuMAP2_03232 HuMAP2_06926 |
| SDHA | HuMAP2_03232 HuMAP2_04642 HuMAP2_04832 HuMAP2_05446 |
| SDHB | HuMAP2_03232 HuMAP2_04642 |
| ELAVL1 | HuMAP2_00999 HuMAP2_02857 HuMAP2_03232 HuMAP2_05399 |