hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03249
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BMP1 | Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.19) (Mammalian tolloid protein) (mTld) (Procollagen C-proteinase) (PCP) | UniProt NCBI |
| RMND5B | E3 ubiquitin-protein transferase RMND5B (EC 2.3.2.27) (Protein RMD5 homolog B) | UniProt NCBI |
| TLL1 | Tolloid-like protein 1 (EC 3.4.24.-) | UniProt NCBI |
| TLL2 | Tolloid-like protein 2 (EC 3.4.24.-) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2214320 | 6.14088879325e-07 | 0.75 | BMP1 TLL2 TLL1 | Anchoring fibril formation |
| REAC:R-HSA-2243919 | 1.10114453861e-06 | 0.75 | BMP1 TLL2 TLL1 | Crosslinking of collagen fibrils |
| REAC:R-HSA-2022090 | 3.73348809378e-05 | 0.75 | BMP1 TLL2 TLL1 | Assembly of collagen fibrils and other multimeric structures |
| REAC:R-HSA-1650814 | 5.0922703922e-05 | 0.75 | BMP1 TLL2 TLL1 | Collagen biosynthesis and modifying enzymes |
| REAC:R-HSA-1474290 | 0.00012815247216 | 0.75 | BMP1 TLL2 TLL1 | Collagen formation |
| REAC:R-HSA-1474228 | 0.000458112911853 | 0.75 | BMP1 TLL2 TLL1 | Degradation of the extracellular matrix |
| REAC:R-HSA-1474244 | 0.0041798099551 | 0.75 | BMP1 TLL2 TLL1 | Extracellular matrix organization |
| GO:0022617 | 0.0206918321066 | 0.75 | BMP1 TLL2 TLL1 | extracellular matrix disassembly |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BMP1 | TLL2 | 0.984 | 0.899 | bioplex (BMP1) bioplex_WMM |
| BMP1 | TLL1 | 0.976 | 0.892 | bioplex (BMP1) bioplex_WMM |
| BMP1 | RMND5B | 0.123 | 0.394 | bioplex (BMP1) bioplex_WMM |
| TLL1 | TLL2 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| TLL1 | RMND5B | 0.008 | 0.082 | bioplex_WMM WMM_only |
| TLL2 | RMND5B | 0.008 | 0.082 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03249 has an average edge precision of 0.407 which is ranked 3233 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| BMP1 | HuMAP2_02103 HuMAP2_03249 HuMAP2_05660 |
| RMND5B | HuMAP2_03249 HuMAP2_05660 HuMAP2_06026 |
| TLL1 | HuMAP2_02103 HuMAP2_03249 HuMAP2_05660 |
| TLL2 | HuMAP2_02103 HuMAP2_03249 HuMAP2_05660 |