hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03264
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MIEF1 | Mitochondrial dynamics protein MID51 (Mitochondrial dynamics protein of 51 kDa) (Mitochondrial elongation factor 1) (Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like) (SMCR7-like protein) | UniProt NCBI |
| MAOB | Amine oxidase [flavin-containing] B (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B) | UniProt NCBI |
| MAOA | Amine oxidase [flavin-containing] A (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A) | UniProt NCBI |
| MAB21L2 | Protein mab-21-like 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-141333 | 1.00555407742e-05 | 0.5 | MAOA MAOB | Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB |
| REAC:R-HSA-140179 | 1.00555407742e-05 | 0.5 | MAOA MAOB | Amine Oxidase reactions |
| WP:WP2436 | 0.000130917773883 | 0.5 | MAOA MAOB | Dopamine metabolism |
| KEGG:00360 | 0.000182137179392 | 0.5 | MAOA MAOB | Phenylalanine metabolism |
| KEGG:00340 | 0.00034210450233 | 0.5 | MAOA MAOB | Histidine metabolism |
| KEGG:00350 | 0.000991147720711 | 0.5 | MAOA MAOB | Tyrosine metabolism |
| KEGG:00380 | 0.00133025918726 | 0.5 | MAOA MAOB | Tryptophan metabolism |
| KEGG:00260 | 0.00147979776218 | 0.5 | MAOA MAOB | Glycine, serine and threonine metabolism |
| KEGG:05030 | 0.00206562690353 | 0.5 | MAOA MAOB | Cocaine addiction |
| KEGG:00330 | 0.00225083015122 | 0.5 | MAOA MAOB | Arginine and proline metabolism |
| KEGG:00982 | 0.00352808727693 | 0.5 | MAOA MAOB | Drug metabolism - cytochrome P450 |
| KEGG:05031 | 0.00376859643257 | 0.5 | MAOA MAOB | Amphetamine addiction |
| KEGG:04726 | 0.00887201996914 | 0.5 | MAOA MAOB | Serotonergic synapse |
| KEGG:04728 | 0.014392043024 | 0.5 | MAOA MAOB | Dopaminergic synapse |
| GO:0042420 | 0.0162267366884 | 0.5 | MAOA MAOB | dopamine catabolic process |
| KEGG:05034 | 0.027038855262 | 0.5 | MAOA MAOB | Alcoholism |
| WP:WP4220 | 0.0333519728792 | 0.25 | MAOA | Neurotransmitter Disorders |
| REAC:R-HSA-211945 | 0.0356320611636 | 0.5 | MAOA MAOB | Phase I - Functionalization of compounds |
| GO:0042424 | 0.0405595771497 | 0.5 | MAOA MAOB | catecholamine catabolic process |
| GO:0019614 | 0.0405595771497 | 0.5 | MAOA MAOB | catechol-containing compound catabolic process |
| REAC:R-HSA-5579012 | 0.0499190562503 | 0.25 | MAOA | Defective MAOA causes Brunner syndrome (BRUNS) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MAOA | MIEF1 | 0.34 | 0.528 | bioplex (MAOA) bioplex_WMM |
| MIEF1 | MAB21L2 | 0.173 | 0.432 | bioplex (MAB21L2) bioplex_WMM |
| MAOB | MAOA | 0.093 | 0.355 | bioplex (MAOA) bioplex_WMM |
| MAOB | MIEF1 | 0.008 | 0.067 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03264 has an average edge precision of 0.345 which is ranked 4053 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MIEF1 | HuMAP2_03264 HuMAP2_05465 HuMAP2_06628 |
| MAOB | HuMAP2_03264 HuMAP2_04031 HuMAP2_06628 |
| MAOA | HuMAP2_03264 HuMAP2_05465 HuMAP2_06628 |
| MAB21L2 | HuMAP2_03264 HuMAP2_04517 HuMAP2_05975 HuMAP2_06359 HuMAP2_06683 |