hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03273
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MSH6 | DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) | UniProt NCBI |
| MSH2 | DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1078 | 1.67592346237e-06 | 1.0 | MSH6 MSH2 | MSH2-MSH6 complex |
| CORUM:2740 | 1.67592346237e-06 | 1.0 | MSH6 MSH2 | MSH2-MSH6 complex |
| CORUM:374 | 1.67592346237e-06 | 1.0 | MSH6 MSH2 | MSH2-MSH6 complex |
| REAC:R-HSA-5632968 | 1.67592346237e-06 | 1.0 | MSH6 MSH2 | Defective Mismatch Repair Associated With MSH6 |
| CORUM:286 | 5.02777038712e-06 | 1.0 | MSH6 MSH2 | PCNA-MSH2-MSH6 complex |
| CORUM:289 | 5.02777038712e-06 | 1.0 | MSH6 MSH2 | PCNA-MSH2-MSH6 complex |
| CORUM:377 | 5.02777038712e-06 | 1.0 | MSH6 MSH2 | PCNA-MSH2-MSH6 complex |
| REAC:R-HSA-5632928 | 5.02777038712e-06 | 1.0 | MSH6 MSH2 | Defective Mismatch Repair Associated With MSH2 |
| CORUM:2226 | 5.02777038712e-06 | 1.0 | MSH6 MSH2 | MutS-alpha-PK-zeta complex |
| HP:0006758 | 1.00182980306e-05 | 1.0 | MSH6 MSH2 | Malignant genitourinary tract tumor |
| HP:0100684 | 1.00182980306e-05 | 1.0 | MSH6 MSH2 | Salivary gland neoplasm |
| CORUM:370 | 1.00555407742e-05 | 1.0 | MSH6 MSH2 | MSH2-MSH6-PMS1-MLH1 complex |
| CORUM:369 | 1.00555407742e-05 | 1.0 | MSH6 MSH2 | MSH2-MSH6-PMS2-MLH1 complex |
| CORUM:431 | 1.00555407742e-05 | 1.0 | MSH6 MSH2 | MSH2-MSH6-PMS2-MLH1 complex |
| WP:WP531 | 1.34129279418e-05 | 1.0 | MSH6 MSH2 | DNA Mismatch Repair |
| CORUM:2224 | 1.67592346237e-05 | 1.0 | MSH6 MSH2 | MSH2/6-BLM-p53-RAD51 complex |
| CORUM:376 | 1.67592346237e-05 | 1.0 | MSH6 MSH2 | PCNA-MutS-alpha-MutL-alpha-DNA complex |
| REAC:R-HSA-5423599 | 1.67592346237e-05 | 1.0 | MSH6 MSH2 | Diseases of Mismatch Repair (MMR) |
| HP:0012118 | 2.00365960613e-05 | 1.0 | MSH6 MSH2 | Laryngeal carcinoma |
| HP:0100605 | 2.00365960613e-05 | 1.0 | MSH6 MSH2 | Neoplasm of the larynx |
| KEGG:03430 | 3.69120786663e-05 | 1.0 | MSH6 MSH2 | Mismatch repair |
| CORUM:434 | 4.69258569465e-05 | 1.0 | MSH6 MSH2 | BASC (Ab 80) complex (BRCA1-associated genome surveillance complex) |
| HP:0000997 | 5.00914901532e-05 | 1.0 | MSH6 MSH2 | Axillary freckling |
| CORUM:438 | 7.54165558069e-05 | 1.0 | MSH6 MSH2 | GCN5-TRRAP histone acetyltransferase complex |
| CORUM:433 | 0.000110610948517 | 1.0 | MSH6 MSH2 | BASC complex (BRCA1-associated genome surveillance complex) |
| REAC:R-HSA-5358565 | 0.000152509035076 | 1.0 | MSH6 MSH2 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) |
| REAC:R-HSA-5358508 | 0.000175971963549 | 1.0 | MSH6 MSH2 | Mismatch Repair |
| HP:0010286 | 0.000303888373596 | 1.0 | MSH6 MSH2 | Abnormal salivary gland morphology |
| HP:0002888 | 0.000303888373596 | 1.0 | MSH6 MSH2 | Ependymoma |
| HP:0100571 | 0.000303888373596 | 1.0 | MSH6 MSH2 | Cardiac diverticulum |
| WP:WP1971 | 0.000336440942541 | 1.0 | MSH6 MSH2 | Integrated Cancer Pathway |
| HP:0002885 | 0.000350640431072 | 1.0 | MSH6 MSH2 | Medulloblastoma |
| KEGG:01524 | 0.00037291412281 | 1.0 | MSH6 MSH2 | Platinum drug resistance |
| GO:0032301 | 0.000450823411379 | 1.0 | MSH6 MSH2 | MutSalpha complex |
| GO:0032143 | 0.000450823411379 | 1.0 | MSH6 MSH2 | single thymine insertion binding |
| GO:0032137 | 0.000450823411379 | 1.0 | MSH6 MSH2 | guanine/thymine mispair binding |
| HP:0012114 | 0.000454162844056 | 1.0 | MSH6 MSH2 | Endometrial carcinoma |
| KEGG:05210 | 0.000484525744074 | 1.0 | MSH6 MSH2 | Colorectal cancer |
| HP:0009592 | 0.000510933199563 | 1.0 | MSH6 MSH2 | Astrocytoma |
| HP:0009720 | 0.000510933199563 | 1.0 | MSH6 MSH2 | Adenoma sebaceum |
| HP:0030126 | 0.000571042987746 | 1.0 | MSH6 MSH2 | Abnormality of the endometrium |
| HP:0012174 | 0.000571042987746 | 1.0 | MSH6 MSH2 | Glioblastoma multiforme |
| HP:0100707 | 0.000571042987746 | 1.0 | MSH6 MSH2 | Abnormality of the astrocytes |
| HP:0002859 | 0.000634492208607 | 1.0 | MSH6 MSH2 | Rhabdomyosarcoma |
| HP:0010615 | 0.000771408948359 | 1.0 | MSH6 MSH2 | Angiofibromas |
| WP:WP4216 | 0.000925864609319 | 1.0 | MSH6 MSH2 | Chromosomal and microsatellite instability in colorectal cancer |
| HP:0009728 | 0.00100182980306 | 1.0 | MSH6 MSH2 | Neoplasm of striated muscle |
| HP:0006725 | 0.00100182980306 | 1.0 | MSH6 MSH2 | Pancreatic adenocarcinoma |
| HP:0002893 | 0.00117214086958 | 1.0 | MSH6 MSH2 | Pituitary adenoma |
| HP:0010524 | 0.00117214086958 | 1.0 | MSH6 MSH2 | Agnosia |
| GO:0032142 | 0.00135247023414 | 1.0 | MSH6 MSH2 | single guanine insertion binding |
| HP:0006749 | 0.00155283619475 | 1.0 | MSH6 MSH2 | Malignant gastrointestinal tract tumors |
| HP:0002672 | 0.00155283619475 | 1.0 | MSH6 MSH2 | Gastrointestinal carcinoma |
| HP:0100576 | 0.00165635860773 | 1.0 | MSH6 MSH2 | Amaurosis fugax |
| HP:0040277 | 0.00176322045339 | 1.0 | MSH6 MSH2 | Neoplasm of the pituitary gland |
| HP:0011750 | 0.00176322045339 | 1.0 | MSH6 MSH2 | Neoplasm of the anterior pituitary |
| HP:0100743 | 0.00176322045339 | 1.0 | MSH6 MSH2 | Neoplasm of the rectum |
| HP:0009733 | 0.00187342173173 | 1.0 | MSH6 MSH2 | Glioma |
| HP:0003006 | 0.00210384258643 | 1.0 | MSH6 MSH2 | Neuroblastoma |
| HP:0100613 | 0.00210384258643 | 1.0 | MSH6 MSH2 | Death in early adulthood |
| HP:0004376 | 0.00210384258643 | 1.0 | MSH6 MSH2 | Neuroblastic tumor |
| HP:0030067 | 0.00210384258643 | 1.0 | MSH6 MSH2 | Peripheral primitive neuroectodermal neoplasm |
| HP:0010526 | 0.0022240621628 | 1.0 | MSH6 MSH2 | Dysgraphia |
| HP:0003003 | 0.0022240621628 | 1.0 | MSH6 MSH2 | Colon cancer |
| HP:0030065 | 0.00234762117185 | 1.0 | MSH6 MSH2 | Primitive neuroectodermal tumor |
| HP:0100649 | 0.00247451961357 | 1.0 | MSH6 MSH2 | Neoplasm of the oral cavity |
| HP:0010784 | 0.00260475748797 | 1.0 | MSH6 MSH2 | Uterine neoplasm |
| GO:0032138 | 0.00270494046827 | 1.0 | MSH6 MSH2 | single base insertion or deletion binding |
| HP:0001480 | 0.00273833479504 | 1.0 | MSH6 MSH2 | Freckling |
| HP:0002671 | 0.00345631282057 | 1.0 | MSH6 MSH2 | Basal cell carcinoma |
| HP:0200008 | 0.00345631282057 | 1.0 | MSH6 MSH2 | Intestinal polyposis |
| WP:WP1984 | 0.00383609739137 | 1.0 | MSH6 MSH2 | Integrated Breast Cancer Pathway |
| HP:0001402 | 0.00392717282801 | 1.0 | MSH6 MSH2 | Hepatocellular carcinoma |
| HP:0100606 | 0.00392717282801 | 1.0 | MSH6 MSH2 | Neoplasm of the respiratory system |
| HP:0100273 | 0.00425777666302 | 1.0 | MSH6 MSH2 | Neoplasm of the colon |
| HP:0005266 | 0.00425777666302 | 1.0 | MSH6 MSH2 | Intestinal polyp |
| HP:0010614 | 0.00425777666302 | 1.0 | MSH6 MSH2 | Fibroma |
| HP:0012316 | 0.00460173822874 | 1.0 | MSH6 MSH2 | Fibrous tissue neoplasm |
| HP:0003002 | 0.00495905752517 | 1.0 | MSH6 MSH2 | Breast carcinoma |
| HP:0100615 | 0.0053297345523 | 1.0 | MSH6 MSH2 | Ovarian neoplasm |
| HP:0100031 | 0.0053297345523 | 1.0 | MSH6 MSH2 | Neoplasm of the thyroid gland |
| HP:0006753 | 0.0053297345523 | 1.0 | MSH6 MSH2 | Neoplasm of the stomach |
| HP:0030063 | 0.00552008221488 | 1.0 | MSH6 MSH2 | Neuroepithelial neoplasm |
| HP:0030061 | 0.00571376931014 | 1.0 | MSH6 MSH2 | Neuroectodermal neoplasm |
| HP:0030060 | 0.00571376931014 | 1.0 | MSH6 MSH2 | Nervous tissue neoplasm |
| HP:0100836 | 0.00631486719198 | 1.0 | MSH6 MSH2 | Malignant neoplasm of the central nervous system |
| HP:0001034 | 0.00631486719198 | 1.0 | MSH6 MSH2 | Hypermelanotic macule |
| HP:0010622 | 0.00673229627659 | 1.0 | MSH6 MSH2 | Neoplasm of the skeletal system |
| GO:0032135 | 0.00676235117068 | 1.0 | MSH6 MSH2 | DNA insertion or deletion binding |
| GO:0043570 | 0.00676235117068 | 1.0 | MSH6 MSH2 | maintenance of DNA repeat elements |
| GO:0032405 | 0.00676235117068 | 1.0 | MSH6 MSH2 | MutLalpha complex binding |
| HP:0100834 | 0.00694601996791 | 1.0 | MSH6 MSH2 | Neoplasm of the large intestine |
| HP:0002516 | 0.00694601996791 | 1.0 | MSH6 MSH2 | Increased intracranial pressure |
| HP:0012640 | 0.00694601996791 | 1.0 | MSH6 MSH2 | Abnormality of intracranial pressure |
| HP:0100835 | 0.00829849020205 | 1.0 | MSH6 MSH2 | Benign neoplasm of the central nervous system |
| HP:0002894 | 0.0085355899221 | 1.0 | MSH6 MSH2 | Neoplasm of the pancreas |
| HP:0100013 | 0.00877602907484 | 1.0 | MSH6 MSH2 | Neoplasm of the breast |
| GO:0051096 | 0.00946729163895 | 1.0 | MSH6 MSH2 | positive regulation of helicase activity |
| GO:0032300 | 0.00946729163895 | 1.0 | MSH6 MSH2 | mismatch repair complex |
| HP:0002282 | 0.00951738312911 | 1.0 | MSH6 MSH2 | Gray matter heterotopia |
| HP:0002034 | 0.0102887920775 | 1.0 | MSH6 MSH2 | Abnormality of the rectum |
| HP:0002896 | 0.0113640893994 | 1.0 | MSH6 MSH2 | Neoplasm of the liver |
| HP:0010785 | 0.0113640893994 | 1.0 | MSH6 MSH2 | Gonadal neoplasm |
| HP:0030448 | 0.0113640893994 | 1.0 | MSH6 MSH2 | Soft tissue sarcoma |
| HP:0009726 | 0.0127833482871 | 1.0 | MSH6 MSH2 | Renal neoplasm |
| HP:0002665 | 0.0130772183627 | 1.0 | MSH6 MSH2 | Lymphoma |
| HP:0000957 | 0.0136749768118 | 1.0 | MSH6 MSH2 | Cafe-au-lait spot |
| HP:0003401 | 0.0136749768118 | 1.0 | MSH6 MSH2 | Paresthesia |
| HP:0100568 | 0.0145966602306 | 1.0 | MSH6 MSH2 | Neoplasm of the endocrine system |
| HP:0012733 | 0.0145966602306 | 1.0 | MSH6 MSH2 | Macule |
| HP:0031105 | 0.0155483985436 | 1.0 | MSH6 MSH2 | Abnormal uterus morphology |
| KEGG:05200 | 0.0157394270613 | 1.0 | MSH6 MSH2 | Pathways in cancer |
| GO:0032357 | 0.0162296428096 | 1.0 | MSH6 MSH2 | oxidized purine DNA binding |
| GO:0030983 | 0.0162296428096 | 1.0 | MSH6 MSH2 | mismatched DNA binding |
| HP:0002354 | 0.0175420398516 | 1.0 | MSH6 MSH2 | Memory impairment |
| HP:0010786 | 0.0178860014174 | 1.0 | MSH6 MSH2 | Urinary tract neoplasm |
| HP:0100242 | 0.0185839428468 | 1.0 | MSH6 MSH2 | Sarcoma |
| HP:0010787 | 0.0200198988979 | 1.0 | MSH6 MSH2 | Genital neoplasm |
| GO:0032356 | 0.020287053512 | 1.0 | MSH6 MSH2 | oxidized DNA binding |
| HP:0002239 | 0.0203872364924 | 1.0 | MSH6 MSH2 | Gastrointestinal hemorrhage |
| HP:0100006 | 0.0211319299793 | 1.0 | MSH6 MSH2 | Neoplasm of the central nervous system |
| HP:0007400 | 0.0222740159548 | 1.0 | MSH6 MSH2 | Irregular hyperpigmentation |
| HP:0011772 | 0.0226613901453 | 1.0 | MSH6 MSH2 | Abnormality of thyroid morphology |
| HP:0002076 | 0.0226613901453 | 1.0 | MSH6 MSH2 | Migraine |
| HP:0100705 | 0.0242442812341 | 1.0 | MSH6 MSH2 | Abnormality of the glial cells |
| HP:0001909 | 0.0242442812341 | 1.0 | MSH6 MSH2 | Leukemia |
| GO:0051095 | 0.0247952876258 | 1.0 | MSH6 MSH2 | regulation of helicase activity |
| GO:0032404 | 0.0247952876258 | 1.0 | MSH6 MSH2 | mismatch repair complex binding |
| HP:0000737 | 0.0267188008477 | 1.0 | MSH6 MSH2 | Irritability |
| HP:0000738 | 0.0271429087977 | 1.0 | MSH6 MSH2 | Hallucinations |
| HP:0001522 | 0.0297576845837 | 1.0 | MSH6 MSH2 | Death in infancy |
| HP:0001600 | 0.0306559919738 | 1.0 | MSH6 MSH2 | Abnormality of the larynx |
| HP:0004375 | 0.0329602005208 | 1.0 | MSH6 MSH2 | Neoplasm of the nervous system |
| HP:0007379 | 0.0378190750657 | 1.0 | MSH6 MSH2 | Neoplasm of the genitourinary tract |
| HP:0008069 | 0.0383233293999 | 1.0 | MSH6 MSH2 | Neoplasm of the skin |
| HP:0000763 | 0.0383233293999 | 1.0 | MSH6 MSH2 | Sensory neuropathy |
| HP:0001123 | 0.0403737410635 | 1.0 | MSH6 MSH2 | Visual field defect |
| HP:0002250 | 0.0440905296328 | 1.0 | MSH6 MSH2 | Abnormal large intestine morphology |
| HP:0000130 | 0.0446348571592 | 1.0 | MSH6 MSH2 | Abnormality of the uterus |
| HP:0004374 | 0.0485386539584 | 1.0 | MSH6 MSH2 | Hemiplegia/hemiparesis |
| HP:0100660 | 0.0491096969462 | 1.0 | MSH6 MSH2 | Dyskinesia |
| REAC:R-HSA-5632927 | 0.0499173803268 | 0.5 | MSH2 | Defective Mismatch Repair Associated With MSH3 |
| CORUM:375 | 0.0499173803268 | 0.5 | MSH2 | MSH2-MSH3 complex |
| CORUM:378 | 0.0499173803268 | 0.5 | MSH2 | MSH2-MSH3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MSH6 | MSH2 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt youn_WMM hein (MSH6) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_03273 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MSH6 | HuMAP2_00403 HuMAP2_02646 HuMAP2_03273 HuMAP2_05731 |
| MSH2 | HuMAP2_03273 HuMAP2_05036 HuMAP2_05731 HuMAP2_06621 |