hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03288
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| COPB1 | Coatomer subunit beta (Beta-coat protein) (Beta-COP) | UniProt NCBI |
| MAPRE2 | Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2) | UniProt NCBI |
| SACM1L | Phosphatidylinositide phosphatase SAC1 (EC 3.1.3.-) (Suppressor of actin mutations 1-like protein) | UniProt NCBI |
| ARCN1 | Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) | UniProt NCBI |
| COPG1 | Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP) | UniProt NCBI |
| COPA | Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin] | UniProt NCBI |
| COPB2 | Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102) | UniProt NCBI |
| COPG2 | Coatomer subunit gamma-2 (Gamma-2-coat protein) (Gamma-2-COP) | UniProt NCBI |
| COPE | Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0030126 | 3.59232854967e-16 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | COPI vesicle coat |
| GO:0030663 | 2.81157896746e-15 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | COPI-coated vesicle membrane |
| GO:0030137 | 9.51275537707e-15 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | COPI-coated vesicle |
| REAC:R-HSA-6811434 | 2.62575142991e-12 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | COPI-dependent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-6807878 | 2.82964214978e-12 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | COPI-mediated anterograde transport |
| GO:0030120 | 3.49770720199e-12 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | vesicle coat |
| REAC:R-HSA-8856688 | 2.3178146297e-11 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | Golgi-to-ER retrograde transport |
| REAC:R-HSA-199977 | 4.81213102701e-11 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | ER to Golgi Anterograde Transport |
| GO:0048475 | 9.03387421086e-11 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | coated membrane |
| GO:0030117 | 9.03387421086e-11 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | membrane coat |
| REAC:R-HSA-948021 | 1.50438155407e-10 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | Transport to the Golgi and subsequent modification |
| GO:0006891 | 1.63972676246e-10 | 0.666666666667 | COPG2 COPG1 COPE COPB1 COPA COPB2 | intra-Golgi vesicle-mediated transport |
| GO:0006890 | 2.73279172275e-10 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| GO:0030660 | 2.97458652937e-10 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | Golgi-associated vesicle membrane |
| REAC:R-HSA-6811442 | 4.46507125551e-10 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| REAC:R-HSA-446203 | 6.06025322848e-09 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | Asparagine N-linked glycosylation |
| GO:0030662 | 6.1454064317e-09 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | coated vesicle membrane |
| GO:0005798 | 8.03179376683e-09 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | Golgi-associated vesicle |
| GO:0006888 | 6.64498229206e-08 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| GO:0000139 | 1.32826284388e-07 | 0.888888888889 | COPG2 COPB2 COPG1 COPE COPB1 SACM1L COPA ARCN1 | Golgi membrane |
| GO:0030135 | 1.70356675029e-07 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | coated vesicle |
| GO:0030133 | 4.66346447741e-07 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | transport vesicle |
| REAC:R-HSA-199991 | 8.88804404405e-07 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 1.29101301448e-06 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | Vesicle-mediated transport |
| GO:0044431 | 2.87849820908e-06 | 0.888888888889 | COPG2 COPB2 COPG1 COPE COPB1 SACM1L COPA ARCN1 | Golgi apparatus part |
| GO:0048193 | 4.35679880959e-06 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | Golgi vesicle transport |
| GO:0005789 | 7.04668365336e-06 | 0.888888888889 | COPG2 COPB2 COPG1 COPE COPB1 SACM1L COPA ARCN1 | endoplasmic reticulum membrane |
| GO:0042175 | 8.02558991656e-06 | 0.888888888889 | COPG2 COPB2 COPG1 COPE COPB1 SACM1L COPA ARCN1 | nuclear outer membrane-endoplasmic reticulum membrane network |
| GO:0098796 | 5.40951179509e-05 | 0.888888888889 | COPG2 COPB2 COPG1 COPE COPB1 SACM1L COPA ARCN1 | membrane protein complex |
| GO:0030659 | 6.9956347379e-05 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | cytoplasmic vesicle membrane |
| GO:0012506 | 8.50955251405e-05 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | vesicle membrane |
| GO:0044432 | 8.61256682196e-05 | 0.888888888889 | COPG2 COPB2 COPG1 COPE COPB1 SACM1L COPA ARCN1 | endoplasmic reticulum part |
| REAC:R-HSA-597592 | 0.000186941393252 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | Post-translational protein modification |
| GO:0005794 | 0.000270838258657 | 0.888888888889 | COPG2 COPB2 COPG1 COPE COPB1 SACM1L COPA ARCN1 | Golgi apparatus |
| GO:0005783 | 0.00148437281102 | 0.888888888889 | COPG2 COPB2 COPG1 COPE COPB1 SACM1L COPA ARCN1 | endoplasmic reticulum |
| GO:0098588 | 0.00175493610277 | 0.888888888889 | COPG2 COPB2 COPG1 COPE COPB1 SACM1L COPA ARCN1 | bounding membrane of organelle |
| REAC:R-HSA-392499 | 0.0022131246723 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | Metabolism of proteins |
| GO:0044433 | 0.0127826629372 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | cytoplasmic vesicle part |
| HPA:015010_13 | 0.0132208150144 | 0.444444444444 | COPA COPG1 COPB1 COPE | epididymis; glandular cells[Supported,High] |
| GO:0098805 | 0.0184453266777 | 0.777777777778 | COPG2 ARCN1 COPG1 COPE COPB1 COPA COPB2 | whole membrane |
| HPA:045010_13 | 0.0271053393931 | 0.444444444444 | COPA COPG1 COPB1 COPE | small intestine; glandular cells[Supported,High] |
| HPA:026020_12 | 0.0396191486554 | 0.444444444444 | COPA COPG1 COPB1 COPE | liver; hepatocytes[Supported,Medium] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| COPA | COPG1 | 1.0 | 0.949 | hein_WMM bioplex (COPG1) bioplex_WMM boldt youn_WMM hein (COPA) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| COPA | ARCN1 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt hein (COPA) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| COPB1 | COPA | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt hein (COPA) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| ARCN1 | COPG1 | 1.0 | 0.949 | hein_WMM bioplex (COPG1) bioplex_WMM Guru boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| COPA | COPB2 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (COPA) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| COPB1 | COPG1 | 1.0 | 0.949 | hein_WMM bioplex (COPG1) bioplex_WMM Guru boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| COPB2 | COPG1 | 1.0 | 0.949 | hein_WMM bioplex (COPG1) bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| COPB1 | ARCN1 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| COPA | COPE | 0.999 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (COPA) gupta_WMM fraction boldt_WMM |
| COPE | COPG1 | 0.992 | 0.911 | hein_WMM bioplex (COPG1) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| COPB1 | COPB2 | 0.953 | 0.86 | hein_WMM bioplex_WMM Guru boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| COPB1 | COPE | 0.877 | 0.811 | hein_WMM bioplex_WMM boldt gupta_WMM fraction boldt_WMM |
| COPB2 | ARCN1 | 0.875 | 0.808 | hein_WMM bioplex_WMM boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| COPE | ARCN1 | 0.775 | 0.752 | hein_WMM bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| COPB2 | COPE | 0.596 | 0.666 | hein_WMM bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| MAPRE2 | COPA | 0.407 | 0.566 | youn_WMM gupta_WMM fraction |
| MAPRE2 | COPG1 | 0.13 | 0.399 | bioplex_WMM youn_WMM gupta_WMM fraction |
| SACM1L | COPG1 | 0.115 | 0.384 | hein_WMM bioplex (COPG1) bioplex_WMM hein (SACM1L) |
| SACM1L | ARCN1 | 0.084 | 0.349 | hein_WMM bioplex_WMM hein (SACM1L) gupta_WMM |
| COPB2 | SACM1L | 0.068 | 0.348 | hein_WMM bioplex_WMM hein (SACM1L) gupta_WMM |
| SACM1L | COPE | 0.058 | 0.325 | hein_WMM bioplex_WMM hein (SACM1L) gupta_WMM |
| COPA | SACM1L | 0.045 | 0.283 | hein_WMM bioplex_WMM hein (SACM1L) gupta_WMM |
| COPG2 | SACM1L | 0.044 | 0.279 | hein_WMM bioplex_WMM hein (SACM1L) |
| MAPRE2 | ARCN1 | 0.043 | 0.27 | gupta_WMM fraction |
| COPB2 | COPG2 | 0.025 | 0.218 | hein_WMM bioplex_WMM boldt boldt_WMM treiber_WMM |
| COPB1 | SACM1L | 0.024 | 0.214 | hein_WMM bioplex_WMM hein (SACM1L) gupta_WMM |
| MAPRE2 | COPB1 | 0.023 | 0.209 | gupta_WMM fraction |
| COPB1 | COPG2 | 0.014 | 0.143 | hein_WMM bioplex_WMM boldt boldt_WMM treiber_WMM |
| MAPRE2 | COPB2 | 0.008 | 0.093 | youn_WMM gupta_WMM fraction |
| MAPRE2 | COPG2 | 0.007 | 0.005 | WMM_only |
| MAPRE2 | SACM1L | 0.007 | 0.002 | gupta_WMM WMM_only |
| COPG2 | COPG1 | 0.007 | 0.005 | hein_WMM bioplex (COPG1) bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| MAPRE2 | COPE | 0.004 | 0.016 | bioplex_WMM youn_WMM gupta_WMM fraction |
| COPA | COPG2 | 0.0 | 0.014 | hein_WMM bioplex_WMM boldt hein (COPA) fraction boldt_WMM treiber_WMM |
| COPG2 | COPE | 0.0 | 0.005 | hein_WMM bioplex_WMM boldt fraction boldt_WMM |
| COPG2 | ARCN1 | 0.0 | 0.001 | hein_WMM bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
Images
Click to enlarge
Complex HuMAP2_03288 has an average edge precision of 0.485 which is ranked 2591 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| COPB1 | HuMAP2_03288 HuMAP2_05017 HuMAP2_06726 |
| MAPRE2 | HuMAP2_00486 HuMAP2_01478 HuMAP2_03288 HuMAP2_05017 |
| SACM1L | HuMAP2_03288 HuMAP2_05017 |
| ARCN1 | HuMAP2_03288 HuMAP2_05017 HuMAP2_06726 |
| COPG1 | HuMAP2_03288 HuMAP2_04381 HuMAP2_05017 HuMAP2_06726 |
| COPA | HuMAP2_03288 HuMAP2_04381 HuMAP2_05017 HuMAP2_06726 |
| COPB2 | HuMAP2_03288 HuMAP2_05017 HuMAP2_06726 |
| COPG2 | HuMAP2_03288 HuMAP2_05017 |
| COPE | HuMAP2_03288 HuMAP2_05017 HuMAP2_06726 |