hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03301
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ALKBH7 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 7) (Spermatogenesis cell proliferation-related protein) (Spermatogenesis-associated protein 11) | UniProt NCBI |
| NDUFAF3 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 | UniProt NCBI |
| NDUFS7 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 1.6.99.3) (EC 7.1.1.2) (Complex I-20kD) (CI-20kD) (NADH-ubiquinone oxidoreductase 20 kDa subunit) (PSST subunit) | UniProt NCBI |
| CHDH | Choline dehydrogenase, mitochondrial (CDH) (CHD) (EC 1.1.99.1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0012748 | 0.00986303631958 | 0.5 | NDUFS7 NDUFAF3 | Focal T2 hyperintense brainstem lesion |
| HP:0008316 | 0.0105423007107 | 0.5 | NDUFS7 NDUFAF3 | Abnormal mitochondria in muscle tissue |
| HP:0012747 | 0.0127153557137 | 0.5 | NDUFS7 NDUFAF3 | Abnormal brainstem MRI signal intensity |
| REAC:R-HSA-6799198 | 0.013274030298 | 0.5 | NDUFS7 NDUFAF3 | Complex I biogenesis |
| HP:0025116 | 0.0134847743701 | 0.5 | NDUFS7 NDUFAF3 | Fetal distress |
| HP:0011923 | 0.0134847743701 | 0.5 | NDUFS7 NDUFAF3 | Decreased activity of mitochondrial complex I |
| HP:0007704 | 0.0134847743701 | 0.5 | NDUFS7 NDUFAF3 | Paroxysmal involuntary eye movements |
| HP:0000114 | 0.0150911756538 | 0.5 | NDUFS7 NDUFAF3 | Proximal tubulopathy |
| HP:0004366 | 0.0176695962482 | 0.5 | NDUFS7 NDUFAF3 | Abnormality of glycolysis |
| HP:0003542 | 0.0176695962482 | 0.5 | NDUFS7 NDUFAF3 | Increased serum pyruvate |
| HP:0011013 | 0.023433582519 | 0.5 | NDUFS7 NDUFAF3 | Abnormal circulating carbohydrate concentration |
| HP:0003737 | 0.0300060012618 | 0.5 | NDUFS7 NDUFAF3 | Mitochondrial myopathy |
| HP:0001138 | 0.0300060012618 | 0.5 | NDUFS7 NDUFAF3 | Optic neuropathy |
| HP:0008972 | 0.0413775694569 | 0.5 | NDUFS7 NDUFAF3 | Decreased activity of mitochondrial respiratory chain |
| KEGG:04714 | 0.0427485725169 | 0.5 | NDUFS7 NDUFAF3 | Thermogenesis |
| HP:0011922 | 0.0427529847392 | 0.5 | NDUFS7 NDUFAF3 | Abnormal activity of mitochondrial respiratory chain |
| REAC:R-HSA-611105 | 0.0435915557177 | 0.5 | NDUFS7 NDUFAF3 | Respiratory electron transport |
| HP:0000817 | 0.0441507593067 | 0.5 | NDUFS7 NDUFAF3 | Poor eye contact |
| HP:0003800 | 0.0470133620262 | 0.5 | NDUFS7 NDUFAF3 | Muscle abnormality related to mitochondrial dysfunction |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NDUFS7 | ALKBH7 | 0.087 | 0.353 | bioplex (NDUFS7) bioplex_WMM |
| NDUFS7 | NDUFAF3 | 0.058 | 0.325 | bioplex (NDUFS7) bioplex_WMM boldt youn_WMM boldt_WMM |
| NDUFS7 | CHDH | 0.048 | 0.294 | bioplex (NDUFS7) bioplex_WMM |
| CHDH | ALKBH7 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| NDUFAF3 | CHDH | 0.008 | 0.081 | bioplex_WMM WMM_only boldt_WMM |
| NDUFAF3 | ALKBH7 | 0.008 | 0.044 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03301 has an average edge precision of 0.197 which is ranked 6223 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ALKBH7 | HuMAP2_03301 HuMAP2_03703 |
| NDUFAF3 | HuMAP2_01573 HuMAP2_03301 HuMAP2_03703 HuMAP2_06566 |
| NDUFS7 | HuMAP2_01573 HuMAP2_03301 HuMAP2_03703 HuMAP2_06566 |
| CHDH | HuMAP2_03301 HuMAP2_03703 |