hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_03315
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| FBXO44 | F-box only protein 44 (F-box protein FBX30) (F-box/G-domain protein 3) | UniProt NCBI |
| CDK13 | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | UniProt NCBI |
| CDK12 | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | UniProt NCBI |
| CCNK | Cyclin-K | UniProt NCBI |
| SDAD1 | Protein SDA1 homolog (Nucleolar protein 130) (SDA1 domain-containing protein 1) (hSDA) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6796648 | 0.00010222685444 | 0.6 | CCNK CDK12 CDK13 | TP53 Regulates Transcription of DNA Repair Genes |
| GO:0070816 | 0.000149729915117 | 0.6 | CCNK CDK12 CDK13 | phosphorylation of RNA polymerase II C-terminal domain |
| GO:0019908 | 0.000199619769136 | 0.6 | CCNK CDK12 CDK13 | nuclear cyclin-dependent protein kinase holoenzyme complex |
| GO:0008353 | 0.000739960245213 | 0.6 | CCNK CDK12 CDK13 | RNA polymerase II CTD heptapeptide repeat kinase activity |
| GO:0004693 | 0.00160515829483 | 0.6 | CCNK CDK12 CDK13 | cyclin-dependent protein serine/threonine kinase activity |
| GO:0097472 | 0.00183428165932 | 0.6 | CCNK CDK12 CDK13 | cyclin-dependent protein kinase activity |
| GO:0032786 | 0.00330982532021 | 0.6 | CCNK CDK12 CDK13 | positive regulation of DNA-templated transcription, elongation |
| GO:0002944 | 0.00450823411379 | 0.4 | CCNK CDK12 | cyclin K-CDK12 complex |
| GO:0002945 | 0.00450823411379 | 0.4 | CCNK CDK13 | cyclin K-CDK13 complex |
| GO:0000307 | 0.005924931483 | 0.6 | CCNK CDK12 CDK13 | cyclin-dependent protein kinase holoenzyme complex |
| GO:0032784 | 0.0137266123698 | 0.6 | CCNK CDK12 CDK13 | regulation of DNA-templated transcription, elongation |
| REAC:R-HSA-3700989 | 0.0182828935298 | 0.6 | CCNK CDK12 CDK13 | Transcriptional Regulation by TP53 |
| CORUM:1083 | 0.0499494897235 | 0.2 | CCNK | P-TEFb.4 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CDK12 | CDK13 | 0.997 | 0.934 | bioplex (CDK13) bioplex_WMM youn_WMM |
| CCNK | CDK12 | 0.424 | 0.575 | hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| CDK13 | FBXO44 | 0.08 | 0.351 | bioplex (CDK13) bioplex_WMM |
| CDK12 | SDAD1 | 0.034 | 0.261 | bioplex_WMM youn_WMM gupta_WMM fraction |
| CCNK | CDK13 | 0.024 | 0.214 | bioplex (CDK13) bioplex_WMM youn_WMM |
| CDK12 | FBXO44 | 0.008 | 0.086 | bioplex_WMM WMM_only |
| CCNK | FBXO44 | 0.008 | 0.028 | bioplex_WMM WMM_only |
| CDK13 | SDAD1 | 0.007 | 0.01 | youn_WMM WMM_only |
| CCNK | SDAD1 | 0.007 | 0.001 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_03315 has an average edge precision of 0.273 which is ranked 4978 out of all 6965 complexes.
Related Complexes