hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03322
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NCKAP1 | Nck-associated protein 1 (NAP 1) (Membrane-associated protein HEM-2) (p125Nap1) | UniProt NCBI |
| ABI1 | Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) | UniProt NCBI |
| CYFIP1 | Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:186 | 2.25356268047e-09 | 1.0 | CYFIP1 ABI1 NCKAP1 | Wave-2 complex |
| REAC:R-HSA-5663213 | 2.94261178253e-06 | 1.0 | CYFIP1 ABI1 NCKAP1 | RHO GTPases Activate WASPs and WAVEs |
| GO:0031209 | 5.08584025729e-06 | 1.0 | CYFIP1 ABI1 NCKAP1 | SCAR complex |
| REAC:R-HSA-2029482 | 1.46159459799e-05 | 1.0 | CYFIP1 ABI1 NCKAP1 | Regulation of actin dynamics for phagocytic cup formation |
| KEGG:05130 | 2.7323760985e-05 | 1.0 | CYFIP1 ABI1 NCKAP1 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-2029480 | 3.69388822082e-05 | 1.0 | CYFIP1 ABI1 NCKAP1 | Fcgamma receptor (FCGR) dependent phagocytosis |
| REAC:R-HSA-4420097 | 5.46192807335e-05 | 1.0 | CYFIP1 ABI1 NCKAP1 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-194138 | 7.05188258943e-05 | 1.0 | CYFIP1 ABI1 NCKAP1 | Signaling by VEGF |
| CORUM:2300 | 0.000120778339722 | 0.666666666667 | NCKAP1 CYFIP1 | Profilin 2 complex |
| REAC:R-HSA-195258 | 0.00218937240413 | 1.0 | CYFIP1 ABI1 NCKAP1 | RHO GTPase Effectors |
| REAC:R-HSA-9006934 | 0.00501472976187 | 1.0 | CYFIP1 ABI1 NCKAP1 | Signaling by Receptor Tyrosine Kinases |
| REAC:R-HSA-194315 | 0.00591618280835 | 1.0 | CYFIP1 ABI1 NCKAP1 | Signaling by Rho GTPases |
| GO:0038096 | 0.00613252434596 | 1.0 | CYFIP1 ABI1 NCKAP1 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| GO:0038094 | 0.00613252434596 | 1.0 | CYFIP1 ABI1 NCKAP1 | Fc-gamma receptor signaling pathway |
| GO:0002433 | 0.00613252434596 | 1.0 | CYFIP1 ABI1 NCKAP1 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| GO:0048010 | 0.00613252434596 | 1.0 | CYFIP1 ABI1 NCKAP1 | vascular endothelial growth factor receptor signaling pathway |
| GO:0002431 | 0.00664337883609 | 1.0 | CYFIP1 ABI1 NCKAP1 | Fc receptor mediated stimulatory signaling pathway |
| KEGG:04810 | 0.00772384569084 | 0.666666666667 | NCKAP1 CYFIP1 | Regulation of actin cytoskeleton |
| GO:2000601 | 0.020283420769 | 0.666666666667 | NCKAP1 CYFIP1 | positive regulation of Arp2/3 complex-mediated actin nucleation |
| GO:0030027 | 0.0242409310378 | 1.0 | CYFIP1 ABI1 NCKAP1 | lamellipodium |
| GO:0008154 | 0.0406485782564 | 1.0 | CYFIP1 ABI1 NCKAP1 | actin polymerization or depolymerization |
| GO:0051127 | 0.0486736709081 | 0.666666666667 | NCKAP1 CYFIP1 | positive regulation of actin nucleation |
| CORUM:2294 | 0.0499776345577 | 0.333333333333 | ABI1 | ABI1-WASF2 complex |
| CORUM:2297 | 0.0499776345577 | 0.333333333333 | ABI1 | ABI1-WASL complex |
| CORUM:6504 | 0.0499776345577 | 0.333333333333 | ABI1 | SOS1-ABI1-EPS8L3 complex |
| CORUM:7561 | 0.0499776345577 | 0.333333333333 | NCKAP1 | NCKAP1-WASF3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ABI1 | NCKAP1 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt youn_WMM hein (ABI1) Malo gupta_WMM fraction boldt_WMM |
| CYFIP1 | ABI1 | 0.988 | 0.902 | hein_WMM bioplex_WMM boldt youn_WMM hein (ABI1) gupta_WMM boldt_WMM |
| CYFIP1 | NCKAP1 | 0.072 | 0.356 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_03322 has an average edge precision of 0.736 which is ranked 1233 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NCKAP1 | HuMAP2_00378 HuMAP2_03322 HuMAP2_06225 HuMAP2_06838 |
| ABI1 | HuMAP2_00378 HuMAP2_03322 HuMAP2_06225 HuMAP2_06838 |
| CYFIP1 | HuMAP2_00010 HuMAP2_00378 HuMAP2_03322 HuMAP2_06838 |