hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03324
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MGME1 | Mitochondrial genome maintenance exonuclease 1 (EC 3.1.-.-) | UniProt NCBI |
| PALLD | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | UniProt NCBI |
| IMPA2 | Inositol monophosphatase 2 (IMP 2) (IMPase 2) (EC 3.1.3.25) (Inositol-1(or 4)-monophosphatase 2) (Myo-inositol monophosphatase A2) | UniProt NCBI |
| GRPEL1 | GrpE protein homolog 1, mitochondrial (HMGE) (Mt-GrpE#1) | UniProt NCBI |
| ALDOB | Fructose-bisphosphate aldolase B (EC 4.1.2.13) (Liver-type aldolase) | UniProt NCBI |
| ALMS1 | Alstrom syndrome protein 1 | UniProt NCBI |
| TRIM45 | Tripartite motif-containing protein 45 (RING finger protein 99) | UniProt NCBI |
| AARSD1 | Alanyl-tRNA editing protein Aarsd1 (Alanyl-tRNA synthetase domain-containing protein 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0100626 | 0.00898332183607 | 0.285714285714 | ALDOB ALMS1 | Chronic hepatic failure |
| HP:0002149 | 0.0218481766952 | 0.285714285714 | ALDOB ALMS1 | Hyperuricemia |
| HP:0004368 | 0.0241425774578 | 0.285714285714 | ALDOB ALMS1 | Increased purine level |
| HP:0004396 | 0.0402984044053 | 0.285714285714 | MGME1 PALLD | Poor appetite |
| HP:0002910 | 0.0419977710671 | 0.428571428571 | PALLD ALDOB ALMS1 | Elevated hepatic transaminase |
| HP:0004352 | 0.0465920925289 | 0.285714285714 | ALDOB ALMS1 | Abnormal circulating purine concentration |
| HP:0010932 | 0.0465920925289 | 0.285714285714 | ALDOB ALMS1 | Abnormal circulating nucleobase concentration |
| CORUM:7123 | 0.0499886427319 | 0.142857142857 | GRPEL1 | GRPEL1-GRPEL2 complex |
| CORUM:7124 | 0.0499886427319 | 0.142857142857 | GRPEL1 | HSPA9-GRPEL1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TRIM45 | AARSD1 | 0.931 | 0.846 | bioplex (AARSD1) bioplex_WMM |
| MGME1 | TRIM45 | 0.629 | 0.681 | bioplex (MGME1) bioplex_WMM |
| MGME1 | GRPEL1 | 0.243 | 0.468 | bioplex (MGME1) bioplex_WMM youn_WMM fraction |
| PALLD | GRPEL1 | 0.067 | 0.351 | hein_WMM bioplex (GRPEL1) bioplex_WMM youn_WMM gupta_WMM fraction |
| IMPA2 | GRPEL1 | 0.049 | 0.294 | Guru fraction |
| GRPEL1 | ALDOB | 0.035 | 0.262 | Guru fraction |
| ALMS1 | AARSD1 | 0.021 | 0.186 | bioplex (AARSD1) bioplex_WMM |
| PALLD | ALMS1 | 0.007 | 0.01 | youn_WMM gupta_WMM WMM_only |
| TRIM45 | ALMS1 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| MGME1 | PALLD | 0.007 | 0.003 | youn_WMM WMM_only |
| GRPEL1 | TRIM45 | 0.007 | 0.002 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03324 has an average edge precision of 0.282 which is ranked 4846 out of all 6965 complexes.
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