hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03326
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ZC2HC1A | Zinc finger C2HC domain-containing protein 1A | UniProt NCBI |
| CASTOR2 | Cytosolic arginine sensor for mTORC1 subunit 2 (Cellular arginine sensor for mTORC1 protein 2) (GATS-like protein 2) | UniProt NCBI |
| WDR24 | GATOR complex protein WDR24 (WD repeat-containing protein 24) | UniProt NCBI |
| CASTOR1 | Cytosolic arginine sensor for mTORC1 subunit 1 (Cellular arginine sensor for mTORC1 protein 1) (GATS-like protein 3) | UniProt NCBI |
| MIOS | GATOR complex protein MIOS (Missing oocyte meiosis regulator homolog) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0061700 | 6.03530623185e-08 | 0.8 | CASTOR1 MIOS WDR24 CASTOR2 | GATOR2 complex |
| GO:0035859 | 2.90104413489e-07 | 0.8 | CASTOR1 MIOS WDR24 CASTOR2 | Seh1-associated complex |
| KEGG:04150 | 1.98064768411e-06 | 0.8 | CASTOR1 MIOS WDR24 CASTOR2 | mTOR signaling pathway |
| CORUM:6216 | 6.7059790554e-05 | 0.4 | MIOS WDR24 | GATOR2 complex |
| CORUM:6217 | 0.000187691761896 | 0.4 | MIOS WDR24 | GATOR complex |
| CORUM:6753 | 0.000187691761896 | 0.4 | MIOS WDR24 | SOG complex |
| GO:0032006 | 0.000192129923302 | 0.8 | CASTOR1 MIOS WDR24 CASTOR2 | regulation of TOR signaling |
| GO:0031929 | 0.000354439891603 | 0.8 | CASTOR1 MIOS WDR24 CASTOR2 | TOR signaling |
| GO:0031669 | 0.00155534683144 | 0.8 | CASTOR1 MIOS WDR24 CASTOR2 | cellular response to nutrient levels |
| GO:0031668 | 0.00213856230812 | 0.8 | CASTOR1 MIOS WDR24 CASTOR2 | cellular response to extracellular stimulus |
| GO:0071496 | 0.00488578599782 | 0.8 | CASTOR1 MIOS WDR24 CASTOR2 | cellular response to external stimulus |
| GO:0031667 | 0.00608750012464 | 0.8 | CASTOR1 MIOS WDR24 CASTOR2 | response to nutrient levels |
| GO:0009991 | 0.00812559735038 | 0.8 | CASTOR1 MIOS WDR24 CASTOR2 | response to extracellular stimulus |
| GO:1903576 | 0.0135228859698 | 0.4 | CASTOR1 CASTOR2 | response to L-arginine |
| GO:1903577 | 0.0135228859698 | 0.4 | CASTOR1 CASTOR2 | cellular response to L-arginine |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CASTOR1 | CASTOR2 | 0.998 | 0.943 | bioplex (CASTOR1) bioplex_WMM |
| CASTOR1 | ZC2HC1A | 0.845 | 0.789 | bioplex (CASTOR1) bioplex_WMM |
| MIOS | CASTOR1 | 0.248 | 0.472 | bioplex (CASTOR1) bioplex_WMM |
| WDR24 | CASTOR1 | 0.044 | 0.274 | bioplex (CASTOR1) bioplex_WMM |
| MIOS | WDR24 | 0.014 | 0.141 | hein_WMM bioplex_WMM boldt boldt_WMM |
| WDR24 | CASTOR2 | 0.01 | 0.13 | hein_WMM bioplex_WMM WMM_only |
| MIOS | CASTOR2 | 0.01 | 0.1 | hein_WMM bioplex_WMM WMM_only |
| CASTOR2 | ZC2HC1A | 0.01 | 0.105 | bioplex_WMM WMM_only |
| WDR24 | ZC2HC1A | 0.009 | 0.108 | bioplex_WMM WMM_only |
| MIOS | ZC2HC1A | 0.008 | 0.088 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03326 has an average edge precision of 0.315 which is ranked 4403 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ZC2HC1A | HuMAP2_03326 HuMAP2_04444 HuMAP2_06647 |
| CASTOR2 | HuMAP2_03326 HuMAP2_05258 HuMAP2_06647 |
| WDR24 | HuMAP2_00541 HuMAP2_01606 HuMAP2_03326 HuMAP2_03792 HuMAP2_06753 HuMAP2_06823 |
| CASTOR1 | HuMAP2_03326 HuMAP2_05258 HuMAP2_06647 HuMAP2_06753 |
| MIOS | HuMAP2_00541 HuMAP2_01606 HuMAP2_03326 HuMAP2_03792 HuMAP2_06753 |