hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03335
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NDUFA10 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (Complex I-42kD) (CI-42kD) (NADH-ubiquinone oxidoreductase 42 kDa subunit) | UniProt NCBI |
| NDUFS2 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (EC 1.6.99.3) (EC 7.1.1.2) (Complex I-49kD) (CI-49kD) (NADH-ubiquinone oxidoreductase 49 kDa subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2948 | 9.21757904306e-05 | 1.0 | NDUFA10 NDUFS2 | Respiratory chain complex I (incomplete intermediate), mitochondrial |
| WP:WP4324 | 0.000513417075107 | 1.0 | NDUFA10 NDUFS2 | Mitochondrial complex I assembly model OXPHOS system |
| WP:WP623 | 0.000553283277601 | 1.0 | NDUFA10 NDUFS2 | Oxidative phosphorylation |
| KEGG:00190 | 0.00100713074717 | 1.0 | NDUFA10 NDUFS2 | Oxidative phosphorylation |
| KEGG:05012 | 0.00114894316007 | 1.0 | NDUFA10 NDUFS2 | Parkinson disease |
| KEGG:04723 | 0.0012614301666 | 1.0 | NDUFA10 NDUFS2 | Retrograde endocannabinoid signaling |
| KEGG:04932 | 0.00128068864242 | 1.0 | NDUFA10 NDUFS2 | Non-alcoholic fatty liver disease (NAFLD) |
| CORUM:178 | 0.00130722030065 | 1.0 | NDUFA10 NDUFS2 | Respiratory chain complex I (holoenzyme), mitochondrial |
| WP:WP111 | 0.00159390293709 | 1.0 | NDUFA10 NDUFS2 | Electron Transport Chain (OXPHOS system in mitochondria) |
| HP:0002928 | 0.00165635860773 | 1.0 | NDUFA10 NDUFS2 | Decreased activity of the pyruvate dehydrogenase complex |
| KEGG:05010 | 0.00171881896746 | 1.0 | NDUFA10 NDUFS2 | Alzheimer disease |
| HP:0007183 | 0.00210384258643 | 1.0 | NDUFA10 NDUFS2 | Focal T2 hyperintense basal ganglia lesion |
| REAC:R-HSA-6799198 | 0.00222227451111 | 1.0 | NDUFA10 NDUFS2 | Complex I biogenesis |
| KEGG:05016 | 0.00224682217969 | 1.0 | NDUFA10 NDUFS2 | Huntington disease |
| HP:0012751 | 0.00260475748797 | 1.0 | NDUFA10 NDUFS2 | Abnormal basal ganglia MRI signal intensity |
| KEGG:04714 | 0.00317122901933 | 1.0 | NDUFA10 NDUFS2 | Thermogenesis |
| WP:WP4396 | 0.00347096768628 | 1.0 | NDUFA10 NDUFS2 | Nonalcoholic fatty liver disease |
| HP:0007020 | 0.0053297345523 | 1.0 | NDUFA10 NDUFS2 | Progressive spastic paraplegia |
| HP:0008972 | 0.00611116179869 | 1.0 | NDUFA10 NDUFS2 | Decreased activity of mitochondrial respiratory chain |
| HP:0011922 | 0.00631486719198 | 1.0 | NDUFA10 NDUFS2 | Abnormal activity of mitochondrial respiratory chain |
| REAC:R-HSA-611105 | 0.00732546145404 | 1.0 | NDUFA10 NDUFS2 | Respiratory electron transport |
| HP:0002490 | 0.00877602907484 | 1.0 | NDUFA10 NDUFS2 | Increased CSF lactate |
| HP:0030085 | 0.00877602907484 | 1.0 | NDUFA10 NDUFS2 | Abnormal CSF lactate level |
| HP:0002073 | 0.00926692567834 | 1.0 | NDUFA10 NDUFS2 | Progressive cerebellar ataxia |
| REAC:R-HSA-163200 | 0.011178409494 | 1.0 | NDUFA10 NDUFS2 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| HP:0025454 | 0.0124928176442 | 1.0 | NDUFA10 NDUFS2 | Abnormal CSF metabolite level |
| HP:0002415 | 0.0145966602306 | 1.0 | NDUFA10 NDUFS2 | Leukodystrophy |
| HP:0000712 | 0.0175420398516 | 1.0 | NDUFA10 NDUFS2 | Emotional lability |
| HP:0001258 | 0.0226613901453 | 1.0 | NDUFA10 NDUFS2 | Spastic paraplegia |
| REAC:R-HSA-1428517 | 0.0226752444459 | 1.0 | NDUFA10 NDUFS2 | The citric acid (TCA) cycle and respiratory electron transport |
| HP:0003287 | 0.0234461568244 | 1.0 | NDUFA10 NDUFS2 | Abnormality of mitochondrial metabolism |
| HP:0002421 | 0.0293135400377 | 1.0 | NDUFA10 NDUFS2 | Poor head control |
| HP:0010550 | 0.032492679946 | 1.0 | NDUFA10 NDUFS2 | Paraplegia |
| HP:0000580 | 0.0329602005208 | 1.0 | NDUFA10 NDUFS2 | Pigmentary retinopathy |
| HP:0012103 | 0.0334310605282 | 1.0 | NDUFA10 NDUFS2 | Abnormality of the mitochondrion |
| HP:0002151 | 0.0363263486591 | 1.0 | NDUFA10 NDUFS2 | Increased serum lactate |
| HP:0003128 | 0.0373181601641 | 1.0 | NDUFA10 NDUFS2 | Lactic acidosis |
| HP:0002061 | 0.0424775836499 | 1.0 | NDUFA10 NDUFS2 | Lower limb spasticity |
| HP:0000998 | 0.0430118928782 | 1.0 | NDUFA10 NDUFS2 | Hypertrichosis |
| HP:0002134 | 0.0435495415392 | 1.0 | NDUFA10 NDUFS2 | Abnormality of the basal ganglia |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NDUFA10 | NDUFS2 | 0.857 | 0.794 | hein_WMM bioplex (NDUFA10) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_03335 has an average edge precision of 0.794 which is ranked 941 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NDUFA10 | HuMAP2_00221 HuMAP2_01573 HuMAP2_02247 HuMAP2_02701 HuMAP2_03335 HuMAP2_05195 HuMAP2_06516 |
| NDUFS2 | HuMAP2_01373 HuMAP2_01573 HuMAP2_01600 HuMAP2_02247 HuMAP2_02701 HuMAP2_03335 HuMAP2_06566 |