hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03341
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MT-CYB | Cytochrome b (Complex III subunit 3) (Complex III subunit III) (Cytochrome b-c1 complex subunit 3) (Ubiquinol-cytochrome-c reductase complex cytochrome b subunit) | UniProt NCBI |
| COX7A2L | Cytochrome c oxidase subunit 7A-related protein, mitochondrial (COX7a-related protein) (Cytochrome c oxidase subunit VIIa-related protein) (EB1) | UniProt NCBI |
| UQCRB | Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (QP-C) (Ubiquinol-cytochrome c reductase complex 14 kDa protein) | UniProt NCBI |
| UQCRC1 | Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1) | UniProt NCBI |
| UQCRQ | Cytochrome b-c1 complex subunit 8 (Complex III subunit 8) (Complex III subunit VIII) (Ubiquinol-cytochrome c reductase complex 9.5 kDa protein) (Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04260 | 1.44137673954e-10 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | Cardiac muscle contraction |
| WP:WP111 | 3.15366669892e-10 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | Electron Transport Chain (OXPHOS system in mitochondria) |
| REAC:R-HSA-611105 | 1.34629719469e-09 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | Respiratory electron transport |
| KEGG:00190 | 1.36503606962e-09 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | Oxidative phosphorylation |
| KEGG:05012 | 1.90538509118e-09 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | Parkinson disease |
| WP:WP4396 | 2.26683960218e-09 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | Nonalcoholic fatty liver disease |
| KEGG:04932 | 2.50752636339e-09 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | Non-alcoholic fatty liver disease (NAFLD) |
| REAC:R-HSA-163200 | 3.93382971604e-09 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| GO:0008121 | 4.26853511465e-09 | 0.8 | UQCRB UQCRQ MT-CYB UQCRC1 | ubiquinol-cytochrome-c reductase activity |
| GO:0016679 | 4.26853511465e-09 | 0.8 | UQCRB UQCRQ MT-CYB UQCRC1 | oxidoreductase activity, acting on diphenols and related substances as donors |
| GO:0016681 | 4.26853511465e-09 | 0.8 | UQCRB UQCRQ MT-CYB UQCRC1 | oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor |
| KEGG:05010 | 5.27399268718e-09 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | Alzheimer disease |
| KEGG:05016 | 1.03678831084e-08 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | Huntington disease |
| REAC:R-HSA-1428517 | 2.3513360199e-08 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | The citric acid (TCA) cycle and respiratory electron transport |
| KEGG:04714 | 2.47068071467e-08 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | Thermogenesis |
| GO:0006122 | 4.0237537548e-08 | 0.8 | UQCRB UQCRQ MT-CYB UQCRC1 | mitochondrial electron transport, ubiquinol to cytochrome c |
| GO:0042775 | 1.72940527637e-07 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | mitochondrial ATP synthesis coupled electron transport |
| GO:0009055 | 1.84625698423e-07 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | electron transfer activity |
| GO:0042773 | 1.84625698423e-07 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | ATP synthesis coupled electron transport |
| GO:0022904 | 3.80961167992e-07 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | respiratory electron transport chain |
| GO:0022900 | 4.02855487991e-07 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | electron transport chain |
| GO:0006119 | 1.4961513763e-06 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | oxidative phosphorylation |
| GO:0045333 | 3.94038719129e-06 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | cellular respiration |
| GO:0015980 | 2.07718623633e-05 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | energy derivation by oxidation of organic compounds |
| GO:0046034 | 4.89220746613e-05 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | ATP metabolic process |
| GO:0005746 | 0.000105081675568 | 0.8 | UQCRB UQCRQ MT-CYB UQCRC1 | mitochondrial respirasome |
| GO:0070469 | 0.000132272122238 | 0.8 | UQCRB UQCRQ MT-CYB UQCRC1 | respirasome |
| GO:0045275 | 0.000149729915117 | 0.6 | UQCRB MT-CYB UQCRQ | respiratory chain complex III |
| GO:0005750 | 0.000149729915117 | 0.6 | UQCRB MT-CYB UQCRQ | mitochondrial respiratory chain complex III |
| KEGG:01100 | 0.000225140891789 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | Metabolic pathways |
| GO:0005743 | 0.000395848422674 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | mitochondrial inner membrane |
| GO:0006091 | 0.000492871184013 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | generation of precursor metabolites and energy |
| GO:0019866 | 0.000584960883363 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | organelle inner membrane |
| GO:0055114 | 0.0012737286276 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | oxidation-reduction process |
| GO:0070069 | 0.00160515829483 | 0.6 | UQCRB MT-CYB UQCRQ | cytochrome complex |
| GO:0031966 | 0.00186999534998 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | mitochondrial membrane |
| GO:0005740 | 0.00259545536123 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | mitochondrial envelope |
| GO:0016491 | 0.00382718608595 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | oxidoreductase activity |
| REAC:R-HSA-1430728 | 0.00473657209702 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | Metabolism |
| GO:0044455 | 0.0049971900723 | 0.8 | UQCRB UQCRQ MT-CYB UQCRC1 | mitochondrial membrane part |
| GO:0044429 | 0.0210056852384 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | mitochondrial part |
| GO:0031975 | 0.0253087624128 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | envelope |
| GO:0031967 | 0.0253087624128 | 1.0 | UQCRC1 UQCRB UQCRQ COX7A2L MT-CYB | organelle envelope |
| HP:0001941 | 0.0347361605983 | 0.6 | UQCRB MT-CYB UQCRQ | Acidosis |
| HP:0004360 | 0.0450566918732 | 0.6 | UQCRB MT-CYB UQCRQ | Abnormality of acid-base homeostasis |
| GO:0098803 | 0.0452171392335 | 0.6 | UQCRB MT-CYB UQCRQ | respiratory chain complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| UQCRB | UQCRC1 | 0.446 | 0.589 | bioplex (UQCRB) bioplex_WMM boldt_WMM |
| UQCRB | UQCRQ | 0.445 | 0.589 | bioplex (UQCRB,UQCRQ) bioplex_WMM fraction |
| UQCRC1 | UQCRQ | 0.255 | 0.477 | hein_WMM bioplex (UQCRQ) bioplex_WMM boldt boldt_WMM |
| UQCRB | MT-CYB | 0.233 | 0.471 | bioplex (UQCRB) bioplex_WMM |
| COX7A2L | UQCRQ | 0.096 | 0.357 | bioplex (UQCRQ) bioplex_WMM boldt_WMM |
| UQCRB | COX7A2L | 0.077 | 0.351 | bioplex (UQCRB) bioplex_WMM |
| MT-CYB | UQCRQ | 0.077 | 0.352 | bioplex (UQCRQ) bioplex_WMM fraction |
| COX7A2L | UQCRC1 | 0.012 | 0.149 | bioplex_WMM WMM_only boldt_WMM |
| MT-CYB | COX7A2L | 0.012 | 0.149 | bioplex_WMM WMM_only |
| MT-CYB | UQCRC1 | 0.009 | 0.101 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03341 has an average edge precision of 0.358 which is ranked 3781 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MT-CYB | HuMAP2_00899 HuMAP2_03341 |
| COX7A2L | HuMAP2_03341 |
| UQCRB | HuMAP2_00552 HuMAP2_03341 |
| UQCRC1 | HuMAP2_03341 |
| UQCRQ | HuMAP2_03341 |