hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03342
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TSEN15 | tRNA-splicing endonuclease subunit Sen15 (SEN15 homolog) (HsSEN15) (tRNA-intron endonuclease Sen15) | UniProt NCBI |
| TSEN34 | tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34) | UniProt NCBI |
| GREB1L | GREB1-like protein (Growth regulation by estrogen in breast cancer 1-like protein) | UniProt NCBI |
| TSEN2 | tRNA-splicing endonuclease subunit Sen2 (EC 4.6.1.16) (tRNA-intron endonuclease Sen2) (HsSen2) | UniProt NCBI |
| TSEN54 | tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5283 | 9.07524205488e-13 | 0.8 | TSEN15 TSEN54 TSEN2 TSEN34 | tRNA splicing endonuclease |
| REAC:R-HSA-6784531 | 1.15185554341e-07 | 0.8 | TSEN15 TSEN54 TSEN2 TSEN34 | tRNA processing in the nucleus |
| GO:0006388 | 1.22034183608e-07 | 0.8 | TSEN15 TSEN54 TSEN2 TSEN34 | tRNA splicing, via endonucleolytic cleavage and ligation |
| GO:0000394 | 1.66401304789e-07 | 0.8 | TSEN15 TSEN54 TSEN2 TSEN34 | RNA splicing, via endonucleolytic cleavage and ligation |
| GO:0000213 | 9.08185760231e-07 | 0.6 | TSEN54 TSEN2 TSEN34 | tRNA-intron endonuclease activity |
| GO:0000379 | 9.08185760231e-07 | 0.6 | TSEN54 TSEN2 TSEN34 | tRNA-type intron splice site recognition and cleavage |
| REAC:R-HSA-72306 | 1.54378610998e-06 | 0.8 | TSEN15 TSEN54 TSEN2 TSEN34 | tRNA processing |
| GO:0016892 | 9.08002798436e-06 | 0.6 | TSEN54 TSEN2 TSEN34 | endoribonuclease activity, producing 3'-phosphomonoesters |
| CORUM:5284 | 2.0123342217e-05 | 0.4 | TSEN2 TSEN54 | RNA endonuclease (SEN2deltaEx8, SEN54, CLP1) |
| HP:0003577 | 0.000220242419125 | 0.8 | TSEN15 TSEN54 TSEN2 GREB1L | Congenital onset |
| HP:0000253 | 0.000351997622505 | 0.6 | TSEN15 TSEN2 TSEN54 | Progressive microcephaly |
| GO:0004549 | 0.000412725169389 | 0.6 | TSEN54 TSEN2 TSEN34 | tRNA-specific ribonuclease activity |
| GO:0008033 | 0.000495430747346 | 0.8 | TSEN15 TSEN54 TSEN2 TSEN34 | tRNA processing |
| GO:0016894 | 0.000507918241599 | 0.6 | TSEN54 TSEN2 TSEN34 | endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters |
| HP:0007308 | 0.000696775152219 | 0.4 | TSEN2 TSEN54 | Extrapyramidal dyskinesia |
| GO:0006399 | 0.00251850101165 | 0.8 | TSEN15 TSEN54 TSEN2 TSEN34 | tRNA metabolic process |
| REAC:R-HSA-8953854 | 0.00262978456954 | 0.8 | TSEN15 TSEN54 TSEN2 TSEN34 | Metabolism of RNA |
| HP:0005484 | 0.00286833354554 | 0.6 | TSEN15 TSEN2 TSEN54 | Postnatal microcephaly |
| HP:0001321 | 0.00879065778809 | 0.6 | TSEN54 TSEN2 TSEN34 | Cerebellar hypoplasia |
| GO:0000214 | 0.0135228859698 | 0.4 | TSEN2 TSEN54 | tRNA-intron endonuclease complex |
| HP:0009121 | 0.0166603503444 | 1.0 | GREB1L TSEN15 TSEN54 TSEN2 TSEN34 | Abnormal axial skeleton morphology |
| HP:0002179 | 0.0188011826397 | 0.4 | TSEN2 TSEN54 | Opisthotonus |
| GO:0004521 | 0.022411068229 | 0.6 | TSEN54 TSEN2 TSEN34 | endoribonuclease activity |
| HP:0007360 | 0.0261117985092 | 0.6 | TSEN54 TSEN2 TSEN34 | Aplasia/Hypoplasia of the cerebellum |
| HP:0003674 | 0.0305494979542 | 0.8 | TSEN15 TSEN54 TSEN2 GREB1L | Onset |
| HP:0000252 | 0.0326474959437 | 0.8 | TSEN15 TSEN54 TSEN2 TSEN34 | Microcephaly |
| HP:0040195 | 0.0332246010255 | 0.8 | TSEN15 TSEN54 TSEN2 TSEN34 | Decreased head circumference |
| HP:0000478 | 0.0345715487774 | 1.0 | GREB1L TSEN15 TSEN54 TSEN2 TSEN34 | Abnormality of the eye |
| HP:0011842 | 0.0361875215647 | 1.0 | GREB1L TSEN15 TSEN54 TSEN2 TSEN34 | Abnormality of skeletal morphology |
| HP:0000924 | 0.042794211029 | 1.0 | GREB1L TSEN15 TSEN54 TSEN2 TSEN34 | Abnormality of the skeletal system |
| HP:0000234 | 0.043361765796 | 1.0 | GREB1L TSEN15 TSEN54 TSEN2 TSEN34 | Abnormality of the head |
| HP:0000152 | 0.0448070321906 | 1.0 | GREB1L TSEN15 TSEN54 TSEN2 TSEN34 | Abnormality of head or neck |
| GO:0034470 | 0.0482714880996 | 0.8 | TSEN15 TSEN54 TSEN2 TSEN34 | ncRNA processing |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TSEN2 | TSEN54 | 0.465 | 0.602 | bioplex (TSEN2) bioplex_WMM |
| TSEN2 | TSEN34 | 0.232 | 0.47 | bioplex (TSEN2) bioplex_WMM |
| TSEN2 | GREB1L | 0.101 | 0.363 | bioplex (TSEN2) bioplex_WMM |
| TSEN2 | TSEN15 | 0.051 | 0.298 | bioplex (TSEN15,TSEN2) bioplex_WMM |
| TSEN15 | TSEN34 | 0.03 | 0.232 | bioplex (TSEN15) bioplex_WMM fraction |
| TSEN15 | TSEN54 | 0.02 | 0.186 | bioplex (TSEN15) bioplex_WMM |
| TSEN34 | TSEN54 | 0.011 | 0.141 | bioplex_WMM WMM_only |
| TSEN15 | GREB1L | 0.008 | 0.096 | bioplex_WMM WMM_only |
| TSEN34 | GREB1L | 0.008 | 0.035 | bioplex_WMM WMM_only |
| GREB1L | TSEN54 | 0.008 | 0.028 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03342 has an average edge precision of 0.245 which is ranked 5450 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TSEN15 | HuMAP2_03342 HuMAP2_04002 |
| TSEN34 | HuMAP2_03342 HuMAP2_04002 |
| GREB1L | HuMAP2_03342 HuMAP2_04002 |
| TSEN2 | HuMAP2_03342 HuMAP2_04002 |
| TSEN54 | HuMAP2_03342 HuMAP2_04002 |