hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03353
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PRPF4B | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | UniProt NCBI |
| LUC7L2 | Putative RNA-binding protein Luc7-like 2 | UniProt NCBI |
| LUC7L | Putative RNA-binding protein Luc7-like 1 (Putative SR protein LUC7B1) (SR+89) | UniProt NCBI |
| UBE2O | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | UniProt NCBI |
| PRPF38B | Pre-mRNA-splicing factor 38B (Sarcoma antigen NY-SAR-27) | UniProt NCBI |
| CHCHD2P9 | NCBI | |
| SRPK1 | SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) | UniProt NCBI |
| SRPK2 | SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000245 | 0.000229373391109 | 0.571428571429 | SRPK2 LUC7L2 LUC7L SRPK1 | spliceosomal complex assembly |
| WP:WP411 | 0.00104833223372 | 0.428571428571 | SRPK1 PRPF4B SRPK2 | mRNA Processing |
| GO:0003723 | 0.00369263749287 | 1.0 | SRPK2 UBE2O LUC7L PRPF38B PRPF4B LUC7L2 SRPK1 | RNA binding |
| GO:0000377 | 0.00396423123772 | 0.714285714286 | SRPK2 LUC7L2 LUC7L PRPF4B SRPK1 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 0.00396423123772 | 0.714285714286 | SRPK2 LUC7L2 LUC7L PRPF4B SRPK1 | mRNA splicing, via spliceosome |
| GO:0000375 | 0.00415838115463 | 0.714285714286 | SRPK2 LUC7L2 LUC7L PRPF4B SRPK1 | RNA splicing, via transesterification reactions |
| GO:0008380 | 0.00928376179311 | 0.714285714286 | SRPK2 LUC7L2 LUC7L PRPF4B SRPK1 | RNA splicing |
| GO:0006397 | 0.0133528244508 | 0.714285714286 | SRPK2 LUC7L2 LUC7L PRPF4B SRPK1 | mRNA processing |
| GO:0005681 | 0.0224457600324 | 0.571428571429 | LUC7L2 LUC7L PRPF4B PRPF38B | spliceosomal complex |
| GO:0022618 | 0.0493528907409 | 0.571428571429 | SRPK2 LUC7L2 LUC7L SRPK1 | ribonucleoprotein complex assembly |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LUC7L2 | LUC7L | 0.937 | 0.85 | bioplex (LUC7L,LUC7L2) bioplex_WMM youn_WMM gupta_WMM treiber_WMM |
| SRPK2 | LUC7L | 0.914 | 0.839 | bioplex (LUC7L) bioplex_WMM youn_WMM fraction |
| PRPF38B | LUC7L | 0.881 | 0.816 | bioplex (LUC7L) bioplex_WMM youn_WMM gupta_WMM |
| SRPK1 | LUC7L | 0.774 | 0.751 | bioplex (LUC7L,SRPK1) bioplex_WMM youn_WMM gupta_WMM fraction |
| LUC7L | UBE2O | 0.153 | 0.411 | bioplex (LUC7L) bioplex_WMM youn_WMM gupta_WMM |
| PRPF4B | LUC7L | 0.127 | 0.398 | bioplex (LUC7L) bioplex_WMM youn_WMM gupta_WMM fraction |
| CHCHD2P9 | LUC7L | 0.065 | 0.347 | bioplex (LUC7L) bioplex_WMM |
| SRPK1 | SRPK2 | 0.064 | 0.348 | bioplex_WMM boldt youn_WMM boldt_WMM |
| SRPK2 | LUC7L2 | 0.017 | 0.175 | bioplex (LUC7L2) bioplex_WMM youn_WMM |
| CHCHD2P9 | LUC7L2 | 0.011 | 0.141 | bioplex_WMM WMM_only |
| SRPK1 | LUC7L2 | 0.009 | 0.11 | bioplex (LUC7L2,SRPK1) bioplex_WMM youn_WMM gupta_WMM treiber_WMM |
| PRPF38B | LUC7L2 | 0.009 | 0.101 | bioplex (PRPF38B) bioplex_WMM youn_WMM gupta_WMM |
| PRPF4B | PRPF38B | 0.008 | 0.082 | bioplex_WMM youn_WMM WMM_only |
| CHCHD2P9 | PRPF38B | 0.008 | 0.073 | bioplex_WMM WMM_only |
| PRPF38B | SRPK1 | 0.007 | 0.009 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| PRPF38B | SRPK2 | 0.007 | 0.01 | bioplex_WMM youn_WMM WMM_only |
| CHCHD2P9 | SRPK2 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| PRPF4B | CHCHD2P9 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| CHCHD2P9 | SRPK1 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| CHCHD2P9 | UBE2O | 0.007 | 0.002 | bioplex_WMM WMM_only |
| SRPK2 | UBE2O | 0.006 | 0.007 | bioplex_WMM boldt youn_WMM boldt_WMM |
| PRPF4B | SRPK1 | 0.0 | 0.016 | bioplex_WMM Guru youn_WMM fraction |
| PRPF4B | SRPK2 | 0.0 | 0.009 | bioplex_WMM Guru youn_WMM fraction |
| SRPK1 | UBE2O | 0.0 | 0.012 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| PRPF4B | UBE2O | 0.0 | 0.011 | bioplex_WMM youn_WMM fraction |
| PRPF4B | LUC7L2 | 0.0 | 0.003 | bioplex (LUC7L2) bioplex_WMM youn_WMM gupta_WMM |
| LUC7L2 | UBE2O | 0.0 | 0.0 | bioplex (LUC7L2,UBE2O) bioplex_WMM youn_WMM gupta_WMM |
| PRPF38B | UBE2O | 0.0 | 0.003 | bioplex_WMM youn_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_03353 has an average edge precision of 0.198 which is ranked 6209 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PRPF4B | HuMAP2_00359 HuMAP2_03353 HuMAP2_04092 HuMAP2_06262 HuMAP2_06561 |
| LUC7L2 | HuMAP2_03268 HuMAP2_03353 HuMAP2_06895 |
| LUC7L | HuMAP2_03353 HuMAP2_04355 HuMAP2_06190 |
| UBE2O | HuMAP2_03353 HuMAP2_04355 HuMAP2_05006 HuMAP2_05238 |
| PRPF38B | HuMAP2_02300 HuMAP2_03225 HuMAP2_03353 HuMAP2_04355 HuMAP2_06190 |
| CHCHD2P9 | HuMAP2_00653 HuMAP2_00761 HuMAP2_02527 HuMAP2_03353 HuMAP2_06941 |
| SRPK1 | HuMAP2_02899 HuMAP2_03353 HuMAP2_03491 HuMAP2_04347 HuMAP2_06190 |
| SRPK2 | HuMAP2_02899 HuMAP2_03353 HuMAP2_03491 HuMAP2_04347 HuMAP2_06190 |