hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03357
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ALDH4A1 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase) | UniProt NCBI |
| ME3 | NADP-dependent malic enzyme, mitochondrial (NADP-ME) (EC 1.1.1.40) (Malic enzyme 3) | UniProt NCBI |
| GOT2 | Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A) | UniProt NCBI |
| MSRA | Mitochondrial peptide methionine sulfoxide reductase (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase) (Protein-methionine-S-oxide reductase) (PMSR) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4595 | 0.000352218401684 | 0.5 | ALDH4A1 GOT2 | Urea cycle and associated pathways |
| KEGG:00250 | 0.00105499815766 | 0.5 | ALDH4A1 GOT2 | Alanine, aspartate and glutamate metabolism |
| KEGG:00330 | 0.00225083015122 | 0.5 | ALDH4A1 GOT2 | Arginine and proline metabolism |
| REAC:R-HSA-389661 | 0.00436320194063 | 0.5 | ALDH4A1 GOT2 | Glyoxylate metabolism and glycine degradation |
| KEGG:01200 | 0.012776519361 | 0.5 | ME3 GOT2 | Carbon metabolism |
| GO:0019470 | 0.0162267366884 | 0.5 | ALDH4A1 GOT2 | 4-hydroxyproline catabolic process |
| KEGG:00400 | 0.0397753158041 | 0.25 | GOT2 | Phenylalanine, tyrosine and tryptophan biosynthesis |
| WP:WP2542 | 0.0416857670091 | 0.25 | MSRA | Sulindac Metabolic Pathway |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MSRA | ALDH4A1 | 0.863 | 0.8 | fraction |
| MSRA | ME3 | 0.213 | 0.462 | fraction |
| GOT2 | ALDH4A1 | 0.172 | 0.431 | fraction treiber_WMM |
| MSRA | GOT2 | 0.167 | 0.425 | fraction |
| GOT2 | ME3 | 0.101 | 0.363 | fraction |
| ALDH4A1 | ME3 | 0.093 | 0.355 | fraction |
Images
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Complex HuMAP2_03357 has an average edge precision of 0.473 which is ranked 2674 out of all 6965 complexes.
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