hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03365
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDKN2B | Cyclin-dependent kinase 4 inhibitor B (Multiple tumor suppressor 2) (MTS-2) (p14-INK4b) (p15-INK4b) (p15INK4B) | UniProt NCBI |
| CDK6 | Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3998 | 0.000352461939805 | 1.0 | CDK6 CDKN2B | Prader-Willi and Angelman Syndrome |
| KEGG:05222 | 0.000610727119751 | 1.0 | CDK6 CDKN2B | Small cell lung cancer |
| WP:WP45 | 0.000727651340845 | 1.0 | CDK6 CDKN2B | G1 to S cell cycle control |
| REAC:R-HSA-2559585 | 0.000831258037338 | 1.0 | CDK6 CDKN2B | Oncogene Induced Senescence |
| KEGG:04110 | 0.00104170846513 | 1.0 | CDK6 CDKN2B | Cell cycle |
| WP:WP2261 | 0.00123734260264 | 1.0 | CDK6 CDKN2B | Signaling Pathways in Glioblastoma |
| KEGG:04934 | 0.00144000876062 | 1.0 | CDK6 CDKN2B | Cushing syndrome |
| REAC:R-HSA-69231 | 0.0014429701011 | 1.0 | CDK6 CDKN2B | Cyclin D associated events in G1 |
| REAC:R-HSA-69236 | 0.0014429701011 | 1.0 | CDK6 CDKN2B | G1 Phase |
| KEGG:04218 | 0.00152317036077 | 1.0 | CDK6 CDKN2B | Cellular senescence |
| WP:WP4658 | 0.00166357564612 | 1.0 | CDK6 CDKN2B | Small cell lung cancer |
| WP:WP179 | 0.00248511748256 | 1.0 | CDK6 CDKN2B | Cell Cycle |
| KEGG:05203 | 0.00256458703081 | 1.0 | CDK6 CDKN2B | Viral carcinogenesis |
| MIRNA:hsa-miR-7855-5p | 0.00858193963829 | 1.0 | CDK6 CDKN2B | hsa-miR-7855-5p |
| REAC:R-HSA-2559582 | 0.00932651406811 | 1.0 | CDK6 CDKN2B | Senescence-Associated Secretory Phenotype (SASP) |
| REAC:R-HSA-2559580 | 0.0123699910758 | 1.0 | CDK6 CDKN2B | Oxidative Stress Induced Senescence |
| KEGG:05200 | 0.0157394270613 | 1.0 | CDK6 CDKN2B | Pathways in cancer |
| REAC:R-HSA-453279 | 0.0179843346747 | 1.0 | CDK6 CDKN2B | Mitotic G1-G1/S phases |
| REAC:R-HSA-2559583 | 0.0294593826216 | 1.0 | CDK6 CDKN2B | Cellular Senescence |
| WP:WP2249 | 0.0332875339197 | 0.5 | CDK6 | Metastatic brain tumor |
| CORUM:3087 | 0.0499173803268 | 0.5 | CDK6 | CCND1-CDK6 complex |
| CORUM:3088 | 0.0499173803268 | 0.5 | CDK6 | CCND2-CDK6 complex |
| CORUM:3089 | 0.0499173803268 | 0.5 | CDK6 | CCND3-CDK6 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CDKN2B | CDK6 | 0.877 | 0.811 | bioplex (CDK6) bioplex_WMM |
Images
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Complex HuMAP2_03365 has an average edge precision of 0.811 which is ranked 906 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CDKN2B | HuMAP2_01131 HuMAP2_01198 HuMAP2_03365 HuMAP2_06643 |
| CDK6 | HuMAP2_01198 HuMAP2_03365 HuMAP2_04118 HuMAP2_06643 |