hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_03376
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| WLS | Protein wntless homolog (Integral membrane protein GPR177) (Protein evenness interrupted homolog) (EVI) (Putative NF-kappa-B-activating protein 373) | UniProt NCBI |
| N4BP2L2 | NEDD4-binding protein 2-like 2 (Phosphonoformate immuno-associated protein 5) | UniProt NCBI |
| PIK3AP1 | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) | UniProt NCBI |
| WNT4 | Protein Wnt-4 | UniProt NCBI |
| WNT7B | Protein Wnt-7b | UniProt NCBI |
| WNT7A | Protein Wnt-7a | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3238698 | 1.06023874251e-08 | 0.666666666667 | WNT7A WLS WNT4 WNT7B | WNT ligand biogenesis and trafficking |
| WP:WP4150 | 8.94077488385e-06 | 0.5 | WNT7A WNT4 WNT7B | Wnt Signaling in Kidney Disease |
| KEGG:05217 | 4.62479008493e-05 | 0.5 | WNT7A WNT4 WNT7B | Basal cell carcinoma |
| WP:WP4336 | 0.000112911212755 | 0.5 | WNT7A WNT4 WNT7B | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| WP:WP4258 | 0.000157102141644 | 0.5 | WNT7A WNT4 WNT7B | LncRNA involvement in canonical Wnt signaling and colorectal cancer |
| KEGG:04916 | 0.000188524277315 | 0.5 | WNT7A WNT4 WNT7B | Melanogenesis |
| WP:WP399 | 0.000218199246147 | 0.5 | WNT7A WNT4 WNT7B | Wnt Signaling Pathway and Pluripotency |
| REAC:R-HSA-373080 | 0.000223228442122 | 0.5 | WNT7A WNT4 WNT7B | Class B/2 (Secretin family receptors) |
| WP:WP3931 | 0.000225055598061 | 0.5 | WNT7A WNT4 WNT7B | ESC Pluripotency Pathways |
| WP:WP710 | 0.000269213029719 | 0.5 | WNT7A WNT4 WNT7B | DNA Damage Response (only ATM dependent) |
| WP:WP428 | 0.000293296259479 | 0.5 | WNT7A WNT4 WNT7B | Wnt Signaling |
| REAC:R-HSA-195721 | 0.000438032292683 | 0.666666666667 | WNT7A WLS WNT4 WNT7B | Signaling by WNT |
| KEGG:04550 | 0.000499786319182 | 0.5 | WNT7A WNT4 WNT7B | Signaling pathways regulating pluripotency of stem cells |
| WP:WP4239 | 0.000590025525062 | 0.5 | WNT7A WNT4 WNT7B | Epithelial to mesenchymal transition in colorectal cancer |
| KEGG:05224 | 0.000590221771159 | 0.5 | WNT7A WNT4 WNT7B | Breast cancer |
| KEGG:05226 | 0.000603963314278 | 0.5 | WNT7A WNT4 WNT7B | Gastric cancer |
| WP:WP4262 | 0.000644066937114 | 0.5 | WNT7A WNT4 WNT7B | Breast cancer pathway |
| KEGG:04934 | 0.000753196125616 | 0.5 | WNT7A WNT4 WNT7B | Cushing syndrome |
| KEGG:04390 | 0.00076933519084 | 0.5 | WNT7A WNT4 WNT7B | Hippo signaling pathway |
| KEGG:04150 | 0.000802296549804 | 0.5 | WNT7A WNT4 WNT7B | mTOR signaling pathway |
| KEGG:04310 | 0.000853469762609 | 0.5 | WNT7A WNT4 WNT7B | Wnt signaling pathway |
| KEGG:05225 | 0.00107971996751 | 0.5 | WNT7A WNT4 WNT7B | Hepatocellular carcinoma |
| KEGG:05205 | 0.0017821830589 | 0.5 | WNT7A WNT4 WNT7B | Proteoglycans in cancer |
| GO:0030666 | 0.00232863701025 | 0.666666666667 | WNT7A WLS WNT4 WNT7B | endocytic vesicle membrane |
| GO:0005109 | 0.00661098268806 | 0.5 | WNT7A WNT4 WNT7B | frizzled binding |
| HP:0000151 | 0.00682280818411 | 0.333333333333 | WNT7A WNT4 | Aplasia of the uterus |
| KEGG:05165 | 0.0080443443451 | 0.5 | WNT7A WNT4 WNT7B | Human papillomavirus infection |
| REAC:R-HSA-500792 | 0.00865672934131 | 0.5 | WNT7A WNT4 WNT7B | GPCR ligand binding |
| KEGG:05200 | 0.0260948095216 | 0.5 | WNT7A WNT4 WNT7B | Pathways in cancer |
| GO:0030139 | 0.0303912691926 | 0.666666666667 | WNT7A WLS WNT4 WNT7B | endocytic vesicle |
| REAC:R-HSA-162582 | 0.0348492364063 | 0.833333333333 | WNT7A WLS WNT7B PIK3AP1 WNT4 | Signal Transduction |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| WNT4 | WNT7B | 0.998 | 0.941 | bioplex (WNT4) bioplex_WMM |
| WNT7A | WNT7B | 0.449 | 0.593 | bioplex (WNT7A) bioplex_WMM |
| WLS | WNT4 | 0.05 | 0.295 | bioplex (WNT4) bioplex_WMM |
| WNT7A | PIK3AP1 | 0.03 | 0.23 | bioplex (WNT7A) bioplex_WMM |
| WNT4 | N4BP2L2 | 0.02 | 0.186 | bioplex (WNT4) bioplex_WMM |
| WLS | WNT7A | 0.018 | 0.177 | bioplex (WNT7A) bioplex_WMM |
| WNT7B | PIK3AP1 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| WLS | WNT7B | 0.008 | 0.059 | bioplex_WMM WMM_only |
| WNT7B | N4BP2L2 | 0.008 | 0.017 | bioplex_WMM WMM_only |
| WLS | PIK3AP1 | 0.007 | 0.0 | bioplex_WMM WMM_only |
| WLS | N4BP2L2 | 0.006 | 0.008 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_03376 has an average edge precision of 0.234 which is ranked 5634 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| WLS | HuMAP2_02507 HuMAP2_02896 HuMAP2_03376 HuMAP2_06746 |
| N4BP2L2 | HuMAP2_03376 |
| PIK3AP1 | HuMAP2_03376 HuMAP2_04106 |
| WNT4 | HuMAP2_02896 HuMAP2_03376 HuMAP2_05188 HuMAP2_05720 |
| WNT7B | HuMAP2_02896 HuMAP2_03376 HuMAP2_05188 HuMAP2_05720 |
| WNT7A | HuMAP2_02896 HuMAP2_03376 HuMAP2_04106 HuMAP2_05720 |