hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03398
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TUSC2 | Tumor suppressor candidate 2 (Fusion 1 protein) (Fus-1 protein) (PDGFA-associated protein 2) | UniProt NCBI |
| HSPH1 | Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein) | UniProt NCBI |
| NAE1 | NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) (Proto-oncogene protein 1) | UniProt NCBI |
| UBE2M | NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.-) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M) | UniProt NCBI |
| UBA3 | NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.-) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3) | UniProt NCBI |
| ERH | Enhancer of rudimentary homolog | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2162 | 8.39001385941e-06 | 0.333333333333 | NAE1 UBA3 | APPBP1-UBA3 complex |
| GO:0045116 | 0.00123252169378 | 0.5 | UBE2M UBA3 NAE1 | protein neddylation |
| GO:0019781 | 0.00676235117068 | 0.333333333333 | NAE1 UBA3 | NEDD8 activating enzyme activity |
| REAC:R-HSA-8951664 | 0.0103628857892 | 0.5 | UBE2M UBA3 NAE1 | Neddylation |
| REAC:R-HSA-5676590 | 0.0375501136505 | 0.333333333333 | UBE2M UBA3 | NIK-->noncanonical NF-kB signaling |
| REAC:R-HSA-5607761 | 0.0388379782234 | 0.333333333333 | UBE2M UBA3 | Dectin-1 mediated noncanonical NF-kB signaling |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| UBA3 | NAE1 | 0.966 | 0.875 | bioplex_WMM youn_WMM fraction treiber_WMM |
| NAE1 | UBE2M | 0.37 | 0.544 | bioplex (UBE2M) bioplex_WMM youn_WMM gupta_WMM |
| UBA3 | UBE2M | 0.121 | 0.393 | bioplex (UBE2M) bioplex_WMM |
| HSPH1 | NAE1 | 0.063 | 0.347 | bioplex_WMM youn_WMM gupta_WMM fraction |
| HSPH1 | TUSC2 | 0.06 | 0.337 | hein_WMM bioplex_WMM hein (HSPH1) boldt_WMM |
| HSPH1 | ERH | 0.053 | 0.301 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| UBA3 | HSPH1 | 0.009 | 0.09 | bioplex_WMM youn_WMM fraction |
| NAE1 | ERH | 0.007 | 0.004 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| UBA3 | ERH | 0.007 | 0.003 | bioplex_WMM youn_WMM WMM_only |
| HSPH1 | UBE2M | 0.006 | 0.002 | bioplex (UBE2M) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| TUSC2 | NAE1 | 0.006 | 0.01 | bioplex_WMM WMM_only |
| TUSC2 | UBE2M | 0.005 | 0.013 | bioplex_WMM WMM_only |
| UBE2M | ERH | 0.0 | 0.011 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
Images
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Complex HuMAP2_03398 has an average edge precision of 0.225 which is ranked 5770 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TUSC2 | HuMAP2_00413 HuMAP2_03398 |
| HSPH1 | HuMAP2_00413 HuMAP2_03398 |
| NAE1 | HuMAP2_00413 HuMAP2_03398 HuMAP2_05548 HuMAP2_05947 |
| UBE2M | HuMAP2_01352 HuMAP2_01949 HuMAP2_02492 HuMAP2_03398 HuMAP2_04965 HuMAP2_05192 HuMAP2_05548 |
| UBA3 | HuMAP2_00413 HuMAP2_03398 HuMAP2_05548 HuMAP2_05947 |
| ERH | HuMAP2_03008 HuMAP2_03398 HuMAP2_06704 |