hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03405
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NDC80 | Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC) | UniProt NCBI |
| SPC25 | Kinetochore protein Spc25 (hSpc25) | UniProt NCBI |
| NUF2 | Kinetochore protein Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (Cell division cycle-associated protein 1) | UniProt NCBI |
| SPC24 | Kinetochore protein Spc24 (hSpc24) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:127 | 4.53449095762e-14 | 1.0 | NUF2 NDC80 SPC24 SPC25 | NDC80 kinetochore complex |
| GO:0031262 | 2.4395561352e-11 | 1.0 | NUF2 NDC80 SPC24 SPC25 | Ndc80 complex |
| GO:0031617 | 2.4395561352e-11 | 1.0 | NUF2 NDC80 SPC24 SPC25 | NMS complex |
| REAC:R-HSA-141424 | 2.53401411634e-07 | 1.0 | NUF2 NDC80 SPC24 SPC25 | Amplification of signal from the kinetochores |
| REAC:R-HSA-141444 | 2.53401411634e-07 | 1.0 | NUF2 NDC80 SPC24 SPC25 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-69618 | 4.68014787616e-07 | 1.0 | NUF2 NDC80 SPC24 SPC25 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-2500257 | 7.44977867715e-07 | 1.0 | NUF2 NDC80 SPC24 SPC25 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-5663220 | 1.12976343415e-06 | 1.0 | NUF2 NDC80 SPC24 SPC25 | RHO GTPases Activate Formins |
| REAC:R-HSA-2467813 | 4.10034927091e-06 | 1.0 | NUF2 NDC80 SPC24 SPC25 | Separation of Sister Chromatids |
| REAC:R-HSA-68877 | 4.87252320159e-06 | 1.0 | NUF2 NDC80 SPC24 SPC25 | Mitotic Prometaphase |
| REAC:R-HSA-68882 | 4.87252320159e-06 | 1.0 | NUF2 NDC80 SPC24 SPC25 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 4.976193908e-06 | 1.0 | NUF2 NDC80 SPC24 SPC25 | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-69620 | 2.51048958535e-05 | 1.0 | NUF2 NDC80 SPC24 SPC25 | Cell Cycle Checkpoints |
| REAC:R-HSA-195258 | 3.37844063501e-05 | 1.0 | NUF2 NDC80 SPC24 SPC25 | RHO GTPase Effectors |
| CORUM:7542 | 5.02641999304e-05 | 0.5 | NDC80 SPC24 | KNL1-MIS12-NDC80-SPC24-ZWINT complex |
| REAC:R-HSA-68886 | 7.5124113335e-05 | 1.0 | NUF2 NDC80 SPC24 SPC25 | M Phase |
| GO:0000776 | 0.000103670767632 | 1.0 | NUF2 NDC80 SPC24 SPC25 | kinetochore |
| REAC:R-HSA-194315 | 0.000127392742142 | 1.0 | NUF2 NDC80 SPC24 SPC25 | Signaling by Rho GTPases |
| REAC:R-HSA-69278 | 0.000264779714116 | 1.0 | NUF2 NDC80 SPC24 SPC25 | Cell Cycle, Mitotic |
| GO:0000775 | 0.000342608092204 | 1.0 | NUF2 NDC80 SPC24 SPC25 | chromosome, centromeric region |
| REAC:R-HSA-1640170 | 0.000545854331888 | 1.0 | NUF2 NDC80 SPC24 SPC25 | Cell Cycle |
| GO:0000777 | 0.00147288799354 | 0.75 | NUF2 NDC80 SPC25 | condensed chromosome kinetochore |
| GO:0000779 | 0.00331394418715 | 0.75 | NUF2 NDC80 SPC25 | condensed chromosome, centromeric region |
| GO:0098687 | 0.00552286185544 | 1.0 | NUF2 NDC80 SPC24 SPC25 | chromosomal region |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NDC80 | SPC24 | 1.0 | 0.949 | hein_WMM bioplex (SPC24) bioplex_WMM youn_WMM hein (SPC24) gupta_WMM |
| SPC24 | NUF2 | 1.0 | 0.949 | hein_WMM bioplex (SPC24) bioplex_WMM hein (NUF2,SPC24) gupta_WMM |
| SPC25 | SPC24 | 1.0 | 0.949 | hein_WMM bioplex (SPC24,SPC25) bioplex_WMM hein (SPC24) gupta_WMM |
| SPC25 | NUF2 | 0.999 | 0.949 | hein_WMM bioplex (SPC25) bioplex_WMM hein (NUF2) gupta_WMM fraction |
| NDC80 | SPC25 | 0.996 | 0.927 | hein_WMM bioplex (SPC25) bioplex_WMM gupta_WMM |
| NDC80 | NUF2 | 0.975 | 0.887 | hein_WMM bioplex_WMM boldt hein (NDC80,NUF2) gupta_WMM boldt_WMM |
Images
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Complex HuMAP2_03405 has an average edge precision of 0.935 which is ranked 419 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NDC80 | HuMAP2_01723 HuMAP2_03405 HuMAP2_06889 |
| SPC25 | HuMAP2_01723 HuMAP2_02111 HuMAP2_03405 HuMAP2_06889 |
| NUF2 | HuMAP2_01723 HuMAP2_03405 HuMAP2_06889 |
| SPC24 | HuMAP2_01723 HuMAP2_03405 HuMAP2_06889 |