hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03417
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDK9 | Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit) | UniProt NCBI |
| CCNT1 | Cyclin-T1 (CycT1) (Cyclin-T) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-176034 | 1.67592346237e-06 | 1.0 | CCNT1 CDK9 | Interactions of Tat with host cellular proteins |
| CORUM:1082 | 1.67592346237e-06 | 1.0 | CCNT1 CDK9 | P-TEFb.1 complex |
| CORUM:1079 | 1.67592346237e-06 | 1.0 | CCNT1 CDK9 | P-TEFb.1 complex |
| CORUM:2602 | 5.02777038712e-06 | 1.0 | CCNT1 CDK9 | P-TEFb-7SKRNA-HEXIM1 complex |
| CORUM:2605 | 5.02777038712e-06 | 1.0 | CCNT1 CDK9 | CCNT1- CDK9-GRN complex |
| CORUM:2603 | 5.02777038712e-06 | 1.0 | CCNT1 CDK9 | Transcription elongation factor complex (SUPT5H, CDK9, CCNT1) |
| CORUM:2875 | 5.02777038712e-06 | 1.0 | CCNT1 CDK9 | BRD4-P-TEFb complex |
| CORUM:2877 | 5.02777038712e-06 | 1.0 | CCNT1 CDK9 | BRD4-P-TEFb complex |
| CORUM:2878 | 5.02777038712e-06 | 1.0 | CCNT1 CDK9 | P-TEFb-7SKRNA-HEXIM1 complex |
| CORUM:2873 | 5.02777038712e-06 | 1.0 | CCNT1 CDK9 | P-TEFb-7SKRNA-HEXIM1 complex |
| CORUM:2604 | 5.02777038712e-06 | 1.0 | CCNT1 CDK9 | P-TEFb-SKP2 complex |
| CORUM:7566 | 1.00555407742e-05 | 1.0 | CCNT1 CDK9 | 7SK RNP complex |
| CORUM:2601 | 1.00555407742e-05 | 1.0 | CCNT1 CDK9 | P-TEFb-BRD4-TRAP220 complex |
| CORUM:2599 | 1.67592346237e-05 | 1.0 | CCNT1 CDK9 | POLR2A-CCNT1-CDK9-NCL-LEM6-CPSF2 complex |
| CORUM:2600 | 4.69258569465e-05 | 1.0 | CCNT1 CDK9 | BRD4 complex |
| CORUM:6084 | 9.21757904306e-05 | 1.0 | CCNT1 CDK9 | AFF4 super elongation complex (SEC) |
| CORUM:2639 | 0.000130722030065 | 1.0 | CCNT1 CDK9 | HES1 promoter-Notch enhancer complex |
| WP:WP3414 | 0.000162072879297 | 1.0 | CCNT1 CDK9 | Initiation of transcription and translation elongation at the HIV-1 LTR |
| REAC:R-HSA-2173796 | 0.000779304410004 | 1.0 | CCNT1 CDK9 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| REAC:R-HSA-167243 | 0.000831258037338 | 1.0 | CCNT1 CDK9 | Tat-mediated HIV elongation arrest and recovery |
| REAC:R-HSA-167238 | 0.000831258037338 | 1.0 | CCNT1 CDK9 | Pausing and recovery of Tat-mediated HIV elongation |
| REAC:R-HSA-167290 | 0.000940193062392 | 1.0 | CCNT1 CDK9 | Pausing and recovery of HIV elongation |
| REAC:R-HSA-167287 | 0.000940193062392 | 1.0 | CCNT1 CDK9 | HIV elongation arrest and recovery |
| REAC:R-HSA-2173793 | 0.00151335888652 | 1.0 | CCNT1 CDK9 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| REAC:R-HSA-167169 | 0.00158542359541 | 1.0 | CCNT1 CDK9 | HIV Transcription Elongation |
| REAC:R-HSA-167200 | 0.00158542359541 | 1.0 | CCNT1 CDK9 | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| REAC:R-HSA-167246 | 0.00158542359541 | 1.0 | CCNT1 CDK9 | Tat-mediated elongation of the HIV-1 transcript |
| REAC:R-HSA-167152 | 0.00173458078356 | 1.0 | CCNT1 CDK9 | Formation of HIV elongation complex in the absence of HIV Tat |
| KEGG:05202 | 0.00178666132548 | 1.0 | CCNT1 CDK9 | Transcriptional misregulation in cancer |
| REAC:R-HSA-112382 | 0.00286750504412 | 1.0 | CCNT1 CDK9 | Formation of RNA Pol II elongation complex |
| REAC:R-HSA-75955 | 0.00286750504412 | 1.0 | CCNT1 CDK9 | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-6796648 | 0.00316917126735 | 1.0 | CCNT1 CDK9 | TP53 Regulates Transcription of DNA Repair Genes |
| REAC:R-HSA-170834 | 0.00381775364729 | 1.0 | CCNT1 CDK9 | Signaling by TGF-beta Receptor Complex |
| REAC:R-HSA-167172 | 0.004164669804 | 1.0 | CCNT1 CDK9 | Transcription of the HIV genome |
| REAC:R-HSA-6807505 | 0.00452666927187 | 1.0 | CCNT1 CDK9 | RNA polymerase II transcribes snRNA genes |
| REAC:R-HSA-674695 | 0.00556574181855 | 1.0 | CCNT1 CDK9 | RNA Polymerase II Pre-transcription Events |
| REAC:R-HSA-9006936 | 0.00656291627866 | 1.0 | CCNT1 CDK9 | Signaling by TGF-beta family members |
| GO:0097322 | 0.00676235117068 | 1.0 | CCNT1 CDK9 | 7SK snRNA binding |
| GO:0008024 | 0.00946729163895 | 1.0 | CCNT1 CDK9 | cyclin/CDK positive transcription elongation factor complex |
| HPA:013010_13 | 0.0123230652188 | 1.0 | CCNT1 CDK9 | endometrium 1; cells in endometrial stroma[Supported,High] |
| REAC:R-HSA-162909 | 0.0123699910758 | 1.0 | CCNT1 CDK9 | Host Interactions of HIV factors |
| GO:1900364 | 0.0126230555186 | 1.0 | CCNT1 CDK9 | negative regulation of mRNA polyadenylation |
| REAC:R-HSA-162599 | 0.0147112561527 | 1.0 | CCNT1 CDK9 | Late Phase of HIV Life Cycle |
| GO:0031441 | 0.0162296428096 | 1.0 | CCNT1 CDK9 | negative regulation of mRNA 3'-end processing |
| REAC:R-HSA-9018519 | 0.0165413645736 | 1.0 | CCNT1 CDK9 | Estrogen-dependent gene expression |
| REAC:R-HSA-162587 | 0.0177396498492 | 1.0 | CCNT1 CDK9 | HIV Life Cycle |
| HPA:013010_03 | 0.0211166356259 | 1.0 | CCNT1 CDK9 | endometrium 1; cells in endometrial stroma[Uncertain,High] |
| HPA:024010_13 | 0.0277809452741 | 1.0 | CCNT1 CDK9 | kidney; cells in glomeruli[Supported,High] |
| HPA:028010_13 | 0.028650749551 | 1.0 | CCNT1 CDK9 | lymph node; germinal center cells[Supported,High] |
| GO:0019908 | 0.029754345151 | 1.0 | CCNT1 CDK9 | nuclear cyclin-dependent protein kinase holoenzyme complex |
| REAC:R-HSA-8939211 | 0.0347016712119 | 1.0 | CCNT1 CDK9 | ESR-mediated signaling |
| HPA:028020_13 | 0.0368334458561 | 1.0 | CCNT1 CDK9 | lymph node; non-germinal center cells[Supported,High] |
| REAC:R-HSA-162906 | 0.0414841334642 | 1.0 | CCNT1 CDK9 | HIV Infection |
| HPA:056010_13 | 0.0460426452818 | 1.0 | CCNT1 CDK9 | tonsil; germinal center cells[Supported,High] |
| REAC:R-HSA-9006931 | 0.0496844269656 | 1.0 | CCNT1 CDK9 | Signaling by Nuclear Receptors |
| CORUM:1083 | 0.0499173803268 | 0.5 | CDK9 | P-TEFb.4 complex |
| CORUM:3229 | 0.0499173803268 | 0.5 | CDK9 | CDK9-IL6ST complex |
| CORUM:1080 | 0.0499173803268 | 0.5 | CDK9 | P-TEFb.2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CDK9 | CCNT1 | 1.0 | 0.949 | hein_WMM bioplex (CDK9) bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_03417 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CDK9 | HuMAP2_01724 HuMAP2_03417 HuMAP2_04784 HuMAP2_04903 HuMAP2_05318 |
| CCNT1 | HuMAP2_01724 HuMAP2_03417 HuMAP2_04903 HuMAP2_06556 |