hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03420
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PAK5 | Serine/threonine-protein kinase PAK 5 (EC 2.7.11.1) (p21-activated kinase 5) (PAK-5) (p21-activated kinase 7) (PAK-7) | UniProt NCBI |
| ARHGEF11 | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | UniProt NCBI |
| PAK4 | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | UniProt NCBI |
| PAK6 | Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-428540 | 3.86037630079e-07 | 0.75 | PAK5 PAK6 PAK4 | Activation of RAC1 |
| WP:WP4564 | 1.34809896275e-06 | 0.75 | PAK5 PAK6 PAK4 | Neural Crest Cell Migration during Development |
| WP:WP4565 | 1.75019113556e-06 | 0.75 | PAK5 PAK6 PAK4 | Neural Crest Cell Migration in Cancer |
| WP:WP4534 | 2.40067855039e-06 | 0.75 | PAK5 PAK6 PAK4 | Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms |
| WP:WP4205 | 6.58415941968e-06 | 0.75 | PAK5 PAK6 PAK4 | MET in type 1 papillary renal cell carcinoma |
| KEGG:05211 | 1.06536230694e-05 | 0.75 | PAK5 PAK6 PAK4 | Renal cell carcinoma |
| WP:WP4263 | 2.06481472174e-05 | 0.75 | PAK5 PAK6 PAK4 | Pancreatic adenocarcinoma pathway |
| KEGG:04012 | 2.11980782425e-05 | 0.75 | PAK5 PAK6 PAK4 | ErbB signaling pathway |
| WP:WP673 | 2.2194047028e-05 | 0.75 | PAK5 PAK6 PAK4 | ErbB Signaling Pathway |
| KEGG:04660 | 3.14744143419e-05 | 0.75 | PAK5 PAK6 PAK4 | T cell receptor signaling pathway |
| WP:WP4541 | 3.85485625527e-05 | 0.75 | PAK5 PAK6 PAK4 | Hippo-Merlin Signaling Dysregulation |
| WP:WP51 | 8.39876098155e-05 | 0.75 | PAK5 PAK6 PAK4 | Regulation of Actin Cytoskeleton |
| WP:WP4223 | 0.000136289943844 | 0.75 | PAK5 PAK6 PAK4 | Ras Signaling |
| KEGG:04360 | 0.000196203606831 | 0.75 | PAK5 PAK6 PAK4 | Axon guidance |
| REAC:R-HSA-422475 | 0.000258657869731 | 1.0 | ARHGEF11 PAK6 PAK4 PAK5 | Axon guidance |
| KEGG:04014 | 0.00027234077557 | 0.75 | PAK5 PAK6 PAK4 | Ras signaling pathway |
| KEGG:04810 | 0.000285912023079 | 0.75 | PAK5 PAK6 PAK4 | Regulation of actin cytoskeleton |
| KEGG:04510 | 0.000295204681571 | 0.75 | PAK5 PAK6 PAK4 | Focal adhesion |
| KEGG:05170 | 0.000344687561831 | 0.75 | PAK5 PAK6 PAK4 | Human immunodeficiency virus 1 infection |
| REAC:R-HSA-376176 | 0.00212183267287 | 0.75 | PAK5 PAK6 PAK4 | Signaling by ROBO receptors |
| REAC:R-HSA-1266738 | 0.00270117638515 | 1.0 | ARHGEF11 PAK6 PAK4 PAK5 | Developmental Biology |
| WP:WP185 | 0.0071289861505 | 0.5 | PAK4 PAK6 | Integrin-mediated Cell Adhesion |
| WP:WP306 | 0.0290430519819 | 0.5 | PAK4 PAK6 | Focal Adhesion |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PAK4 | PAK6 | 1.0 | 0.949 | bioplex (PAK4) bioplex_WMM |
| PAK5 | PAK4 | 1.0 | 0.949 | bioplex (PAK4,PAK5) bioplex_WMM |
| ARHGEF11 | PAK4 | 0.941 | 0.854 | bioplex (PAK4) bioplex_WMM youn_WMM gupta_WMM |
| ARHGEF11 | PAK5 | 0.248 | 0.472 | bioplex (PAK5) bioplex_WMM |
| PAK5 | PAK6 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| ARHGEF11 | PAK6 | 0.008 | 0.094 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03420 has an average edge precision of 0.571 which is ranked 2076 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PAK5 | HuMAP2_00703 HuMAP2_01506 HuMAP2_02784 HuMAP2_03420 |
| ARHGEF11 | HuMAP2_00703 HuMAP2_02784 HuMAP2_03163 HuMAP2_03420 |
| PAK4 | HuMAP2_00703 HuMAP2_01506 HuMAP2_02784 HuMAP2_03420 |
| PAK6 | HuMAP2_00703 HuMAP2_01506 HuMAP2_02784 HuMAP2_03420 |