hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03421
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| EIF4A1 | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | UniProt NCBI |
| EIF4G2 | Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97) | UniProt NCBI |
| EIF4G3 | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0016281 | 1.49850650438e-05 | 1.0 | EIF4G3 EIF4A1 EIF4G2 | eukaryotic translation initiation factor 4F complex |
| KEGG:03013 | 1.76006400333e-05 | 1.0 | EIF4G3 EIF4A1 EIF4G2 | RNA transport |
| REAC:R-HSA-1169408 | 2.15379400217e-05 | 1.0 | EIF4G3 EIF4A1 EIF4G2 | ISG15 antiviral mechanism |
| REAC:R-HSA-1169410 | 2.9144670159e-05 | 1.0 | EIF4G3 EIF4A1 EIF4G2 | Antiviral mechanism by IFN-stimulated genes |
| REAC:R-HSA-913531 | 0.000387967964833 | 1.0 | EIF4G3 EIF4A1 EIF4G2 | Interferon Signaling |
| KEGG:05416 | 0.000462599152438 | 0.666666666667 | EIF4G3 EIF4G2 | Viral myocarditis |
| GO:0003743 | 0.000968126020406 | 1.0 | EIF4G3 EIF4A1 EIF4G2 | translation initiation factor activity |
| WP:WP4566 | 0.000990815205931 | 0.666666666667 | EIF4G3 EIF4A1 | Translation inhibitors in chronically activated PDGFRA cells |
| WP:WP107 | 0.00117249358059 | 0.666666666667 | EIF4G3 EIF4A1 | Translation Factors |
| GO:0008135 | 0.0051907357126 | 1.0 | EIF4G3 EIF4A1 EIF4G2 | translation factor activity, RNA binding |
| GO:0090079 | 0.00962631496557 | 1.0 | EIF4G3 EIF4A1 EIF4G2 | translation regulator activity, nucleic acid binding |
| GO:0045182 | 0.0196004650773 | 1.0 | EIF4G3 EIF4A1 EIF4G2 | translation regulator activity |
| REAC:R-HSA-1280215 | 0.0245091821355 | 1.0 | EIF4G3 EIF4A1 EIF4G2 | Cytokine Signaling in Immune system |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EIF4A1 | EIF4G2 | 0.718 | 0.73 | hein_WMM youn (EIF4A1) bioplex (EIF4A1) bioplex_WMM boldt youn_WMM fraction boldt_WMM treiber_WMM |
| EIF4A1 | EIF4G3 | 0.713 | 0.728 | youn (EIF4A1) bioplex (EIF4A1) bioplex_WMM youn_WMM |
| EIF4G2 | EIF4G3 | 0.0 | 0.009 | bioplex_WMM youn_WMM fraction |
Images
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Complex HuMAP2_03421 has an average edge precision of 0.489 which is ranked 2561 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| EIF4A1 | HuMAP2_00055 HuMAP2_03421 HuMAP2_04458 HuMAP2_05935 |
| EIF4G2 | HuMAP2_00055 HuMAP2_03421 HuMAP2_05935 |
| EIF4G3 | HuMAP2_00638 HuMAP2_03421 HuMAP2_05690 HuMAP2_05719 |