hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03422
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PLPPR3 | Phospholipid phosphatase-related protein type 3 (EC 3.1.3.4) (Lipid phosphate phosphatase-related protein type 3) (PAP-2-like protein 2) (Plasticity-related gene 2 protein) (PRG-2) | UniProt NCBI |
| PLPPR1 | Phospholipid phosphatase-related protein type 1 (Lipid phosphate phosphatase-related protein type 1) (Plasticity-related gene 3 protein) (PRG-3) | UniProt NCBI |
| PLPP3 | Phospholipid phosphatase 3 (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 3) (PAP2-beta) (Phosphatidate phosphohydrolase type 2b) (Phosphatidic acid phosphatase 2b) (PAP-2b) (PAP2b) (Vascular endothelial growth factor and type I collagen-inducible protein) (VCIP) | UniProt NCBI |
| PLPP2 | Phospholipid phosphatase 2 (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 2) (PAP2-gamma) (PAP2-G) (Phosphatidate phosphohydrolase type 2c) (Phosphatidic acid phosphatase 2c) (PAP-2c) (PAP2c) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0008195 | 3.07384073035e-09 | 1.0 | PLPPR1 PLPP2 PLPP3 PLPPR3 | phosphatidate phosphatase activity |
| GO:0042577 | 3.07384073035e-09 | 1.0 | PLPPR1 PLPP2 PLPP3 PLPPR3 | lipid phosphatase activity |
| GO:0046839 | 3.08603851103e-07 | 1.0 | PLPPR1 PLPP2 PLPP3 PLPPR3 | phospholipid dephosphorylation |
| WP:WP325 | 0.000424263272643 | 0.5 | PLPP2 PLPP3 | Triacylglyceride Synthesis |
| REAC:R-HSA-419408 | 0.000552609179875 | 0.5 | PLPPR1 PLPPR3 | Lysosphingolipid and LPA receptors |
| KEGG:04975 | 0.000869408386689 | 0.5 | PLPP2 PLPP3 | Fat digestion and absorption |
| GO:0030258 | 0.000879263724448 | 1.0 | PLPPR1 PLPP2 PLPP3 PLPPR3 | lipid modification |
| KEGG:00565 | 0.00112083505921 | 0.5 | PLPP2 PLPP3 | Ether lipid metabolism |
| KEGG:00600 | 0.00163726932403 | 0.5 | PLPP2 PLPP3 | Sphingolipid metabolism |
| GO:0016791 | 0.0022746452143 | 1.0 | PLPPR1 PLPP2 PLPP3 PLPPR3 | phosphatase activity |
| KEGG:00561 | 0.00296133374321 | 0.5 | PLPP2 PLPP3 | Glycerolipid metabolism |
| GO:0016311 | 0.00460927796737 | 1.0 | PLPPR1 PLPP2 PLPP3 PLPPR3 | dephosphorylation |
| REAC:R-HSA-1660661 | 0.00562500866147 | 0.5 | PLPP2 PLPP3 | Sphingolipid de novo biosynthesis |
| KEGG:00564 | 0.00613079763587 | 0.5 | PLPP2 PLPP3 | Glycerophospholipid metabolism |
| GO:0042578 | 0.00713971525321 | 1.0 | PLPPR1 PLPP2 PLPP3 PLPPR3 | phosphoric ester hydrolase activity |
| KEGG:04666 | 0.00761107721317 | 0.5 | PLPP2 PLPP3 | Fc gamma R-mediated phagocytosis |
| KEGG:05231 | 0.00778534503861 | 0.5 | PLPP2 PLPP3 | Choline metabolism in cancer |
| GO:0006644 | 0.0111323368581 | 1.0 | PLPPR1 PLPP2 PLPP3 PLPPR3 | phospholipid metabolic process |
| KEGG:04072 | 0.0156041830743 | 0.5 | PLPP2 PLPP3 | Phospholipase D signaling pathway |
| REAC:R-HSA-428157 | 0.0269852439715 | 0.5 | PLPP2 PLPP3 | Sphingolipid metabolism |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PLPPR3 | PLPPR1 | 0.401 | 0.561 | bioplex (PLPPR1) bioplex_WMM |
| PLPPR1 | PLPP3 | 0.29 | 0.492 | bioplex (PLPPR1) bioplex_WMM |
| PLPP3 | PLPP2 | 0.246 | 0.47 | bioplex (PLPP2) bioplex_WMM |
| PLPPR3 | PLPP3 | 0.008 | 0.079 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03422 has an average edge precision of 0.401 which is ranked 3315 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PLPPR3 | HuMAP2_01946 HuMAP2_02780 HuMAP2_02919 HuMAP2_03422 HuMAP2_05193 |
| PLPPR1 | HuMAP2_01946 HuMAP2_02780 HuMAP2_02919 HuMAP2_03422 HuMAP2_05193 HuMAP2_05688 |
| PLPP3 | HuMAP2_01946 HuMAP2_02780 HuMAP2_02919 HuMAP2_03422 HuMAP2_05193 HuMAP2_05688 |
| PLPP2 | HuMAP2_01946 HuMAP2_02919 HuMAP2_03422 HuMAP2_05193 HuMAP2_05688 |